Shahverdi A, Tavassoli F. First lead structure for nitrofurantoin resistance inhibition activity against Enterobacteria. J. Med. Plants 2003; 2 (5) :23-30
URL:
http://jmp.ir/article-1-785-en.html
1- Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran Iran , Shahverdiar@yahoo.com
2- General practitioners, Tehran, Iran
Abstract: (5888 Views)
We have previously shown that the ethanolic diluted essential oils of the aerial parts of Mentha longifolia could have nitrofurantoin resistance breaker activity against nitrofurantoin resistances Entherobacteriaceae. Bioassay-guided fractions of silica gel thin layer chromatography elute using the nitrofurantoin resistance test strains resulted one compound in active fraction containing a monoterpene piperitone. Piperitone at the concentration of 1 mg/mL decreased MICs of all resistance strains to less than 32 μg/mL. In the presence of piperitone the MICs of nitrofurantoin becomes about 8 times smaller than that of in its absence. Also it is found that in the presence of piperitone the emergence of nitrofurantoin-resistant variants among wild type strains is completely suppressed. Taken together, these results indicate that piperitone could have potential therapeutic effect on nitrofurantoin-resistance chemotherapy.
Type of Study:
Research |
Subject:
Pharmacognosy & Pharmaceutics Received: 2001/05/8 | Accepted: 2002/12/14 | Published: 2003/03/19