year 2, Issue 5 (3-2003)                   J. Med. Plants 2003, 2(5): 23-30 | Back to browse issues page

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Shahverdi A, Tavassoli F. First lead structure for nitrofurantoin resistance inhibition activity against Enterobacteria. J. Med. Plants. 2003; 2 (5) :23-30
1- Department of Pharmaceutical Biotechnology, Faculty of Pharmacy, Tehran University of Medical Sciences, Tehran Iran ,
2- General practitioners, Tehran, Iran
Abstract:   (5020 Views)
We have previously shown that the ethanolic diluted essential oils of the aerial parts of Mentha longifolia could have nitrofurantoin resistance breaker activity against nitrofurantoin resistances Entherobacteriaceae. Bioassay-guided fractions of silica gel thin layer chromatography elute using the nitrofurantoin resistance test strains resulted one compound in active fraction containing a monoterpene piperitone. Piperitone at the concentration of 1 mg/mL decreased MICs of all resistance strains to less than 32 μg/mL. In the presence of piperitone the MICs of nitrofurantoin becomes about 8 times smaller than that of in its absence. Also it is found that in the presence of piperitone the emergence of nitrofurantoin-resistant variants among wild type strains is completely suppressed. Taken together, these results indicate that piperitone could have potential therapeutic effect on nitrofurantoin-resistance chemotherapy.
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Type of Study: Research | Subject: Pharmacognosy & Pharmaceutics
Received: 2001/05/8 | Accepted: 2002/12/14 | Published: 2003/03/19

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