year 3, Issue 9 (2-2004)                   J. Med. Plants 2004, 3(9): 15-22 | Back to browse issues page

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Hosseinzadeh H, Mehrabi M. Anti-emtic effect of Trachyspermum ammi L. fruit extracts in young chickens. J. Med. Plants. 2004; 3 (9) :15-22
URL: http://jmp.ir/article-1-751-en.html
1- Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran , hosseinzadehh@yahoo.com
2- Pharmaceutical Research Center, School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
Abstract:   (4461 Views)
The anti-emetic effect of the aqueous and ethanolic extracts of Trachyspermum ammi fruit was studied in young chickens. Emesis was induced in the chickens using copper sulfate (60 mg/kg, orally) and ipecac (600 mg/kg, orally). The LD50 values of the aqueous and ethanolic extracts (i.p.) were 2753 mg/kg and 747 mg/kg in the chickens, respectively. The aqueous extract (800-2000 mg/kg, i.p.) and ethanolic extract (40-100 mg/kg, i.p.) significantly prevented the emesis induced by copper sulfate and ipecac. These results indicate that the extracts of T. ammi fruit extracts have an anti-emetic activity in young chickens with peripheral and central mechanisms.
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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2003/01/13 | Accepted: 2003/11/2 | Published: 2004/03/9

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