year 19, Issue 73 (3-2020)                   J. Med. Plants 2020, 19(73): 1-11 | Back to browse issues page


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Mehrpouri M, Hamidpour R, Hamidpour M. Cinnamon inhibits platelet function and improves cardiovascular system. J. Med. Plants 2020; 19 (73) :1-11
URL: http://jmp.ir/article-1-2280-en.html
1- Department of Medical Laboratory Sciences, School of Allied Medical Sciences, Alborz University of Medical Sciences, Karaj, Iran
2- Department of Herbal Medicine, Pars Biomedical Research, Kansas, USA
3- HSCRC Research Center- Department of Hematology and Blood Banking, School of Allied Medical Sciences, Shahid Beheshti University of Medical Sciences, Tehran, Iran , mohsenhp@sbmu.ac.ir
Abstract:   (9008 Views)
Background: Cinnamon belongs to the Lauraceae family and is one of the most common spices that are used as traditional medicine in the world. The bark and leaf of cinnamon contain essential oils and derivatives including cinnamaldehyde, cinnamic acid and several other compounds such as polyphenols. Moreover, anti-inflammatory and lipid lowering properties of cinnamon has been proven. Objective: The goal of this review is to find out whether cinnamon extract was used as an anticoagulant and anti-aggregation properties for the platelets or not. Methods: Using the search engine tools such as PubMed and Scopus, the articles that were studied cinnamon and its effects on platelets function and cardiovascular disease were under reviewed. Results: This article presents a comprehensive analysis of cinnamon compounds and their effects on platelet function and cardiovascular disease. Conclusion: Taken together, data show that cinnamon extract can inhibit platelet function and as a complementary medicine were used in cardiovascular disorder.
Full-Text [PDF 421 kb]   (3265 Downloads)    
Type of Study: Review | Subject: Medicinal Plants
Received: 2018/09/23 | Accepted: 2018/12/18 | Published: 2020/06/2

References
1. Sangal A. Role of cinnamon as beneficial antidiabetic food adjunct: a review. Advances in Applied Science Res. 2011; 2 (4): 440-50.
2. Hamidpour R, Hamidpour S, Hamidpour M, Shahlari M, Sohraby M, Shahlari N and et al. Russian olive (Elaeagnus angustifolia L.): From a variety of traditional medicinal applications to its novel roles as active antioxidant, anti-inflammatory, anti-mutagenic and analgesic agent. eJTCM 2017; 7 (1): 24-9. [DOI:10.1016/j.jtcme.2015.09.004]
3. R Vasanthi H and P Parameswari R. Indian spices for healthy heart-an overview. Current Cardiology Reviews 2010; 6 (4): 274-9. [DOI:10.2174/157340310793566172]
4. Hamidpour R, Hamidpour S, Hamidpour M, Shahlari M, Sohraby M. Summer Savory: From the Selection of Traditional Applications to the Novel Effect in Relief, Prevention, and Treatment of a Number of Serious Illnesses such as Diabetes, Cardiovascular Disease, Alzheimer 's Disease, and Cancer. eJTCM 2014; 4 (4): 140-144. [DOI:10.4103/2225-4110.136540]
5. Hariri M and Ghiasvand R. Cinnamon and Chronic Diseases. Drug Discovery from Mother Nature. Springer; 2016, pp: 1-24. [DOI:10.1007/978-3-319-41342-6_1]
6. Barceloux DG. Cinnamon (cinnamomum species). Disease-A-Month 2009; 55 (6): 327-35. [DOI:10.1016/j.disamonth.2009.03.003]
7. Senanayake UM, Lee TH and Wills RB. Volatile constituents of cinnamon (Cinnamomum zeylanicum) oils. J. Agricultural and Food Chem. 1978; 26 (4): 822-4. [DOI:10.1021/jf60218a031]
8. Tung Y-T, Chua M-T, Wang S-Y and Chang S-T. Anti-inflammation activities of essential oil and its constituents from indigenous cinnamon (Cinnamomum osmophloeum) twigs. Bioresource Technol. 2008; 99 (9): 3908-13. [DOI:10.1016/j.biortech.2007.07.050]
9. Lin C-T, Chen C-J, Lin T-Y, Tung JC and Wang S-Y. Anti-inflammation activity of fruit essential oil from Cinnamomum insularimontanum Hayata. Bioresource Technol. 2008; 99 (18): 8783-7. [DOI:10.1016/j.biortech.2008.04.041]
10. Tung Y-T, Yen P-L, Lin C-Y and Chang S-T. Anti-inflammatory activities of essential oils and their constituents from different provenances of indigenous cinnamon (Cinnamomum osmophloeum) leaves. Pharmaceutical Biol. 2010; 48 (10): 1130-6. [DOI:10.3109/13880200903527728]
11. Singh G, Maurya S and Catalan CA. A comparison of chemical, antioxidant and antimicrobial studies of cinnamon leaf and bark volatile oils, oleoresins and their constituents. Food and Chemical Toxicol. 2007; 45 (9): 1650-61. [DOI:10.1016/j.fct.2007.02.031]
12. Jayaprakasha GK, Rao LJ and Sakariah KK. Chemical composition of volatile oil from Cinnamomum zeylanicum buds. Zeitschrift für Naturforschung C. 2002; 57 (11-12): 990-3. [DOI:10.1515/znc-2002-11-1206]
13. Jayaprakasha GK, Jagan Mohan Rao L and Sakariah KK. Volatile constituents from Cinnamomum zeylanicum fruit stalks and their antioxidant activities. J. Agricultural and Food Chem. 2003; 51 (15): 4344-8. [DOI:10.1021/jf034169i]
14. Hamidpour R, Hamidpour M, Hamidpour S and Shahlari M. Cinnamon from the selection of traditional applications to its novel effects on the inhibition of angiogenesis in cancer cells and prevention of Alzheimer's disease, and a series of functions such as antioxidant, anticholesterol, antidiabetes, antibacterial, antifungal, nematicidal, acaracidal, and repellent activities. J. Traditional and Complementary Medicine 2015; 5 (2): 66-70. [DOI:10.1016/j.jtcme.2014.11.008]
15. Jakhetia V, Patel R, Khatri P, Pahuja N, Garg S, Pandey A and et al. Cinnamon: a pharmacological review. J. Advanced Scientific Res. 2010; 1 (2): 19-23.
16. Shen Y, Jia L-N, Honma N, Hosono T, Ariga T and Seki T. Beneficial effects of cinnamon on the metabolic syndrome, inflammation, and pain, and mechanisms underlying these effects-a review. eJTCM 2012; 2 (1): 27-32. [DOI:10.1016/S2225-4110(16)30067-0]
17. Aneja KR and Joshi R. Antimicrobial activity of Syzygium aromaticum and its bud oil against dental cares causing microorganisms. Ethnobotanical Leaflets 2010; 14: 960-75.
18. Chang S-T, Chen P-F and Chang S-C. Antibacterial activity of leaf essential oils and their constituents from Cinnamomum osmophloeum. J. Ethnopharmacol. 2001; 77 (1): 123-7. [DOI:10.1016/S0378-8741(01)00273-2]
19. Hili P, Evans C and Veness R. Antimicrobial action of essential oils: the effect of dimethylsulphoxide on the activity of cinnamon oil. Letters in Applied Microbiol. 1997; 24 (4): 269-75. [DOI:10.1046/j.1472-765X.1997.00073.x]
20. Matan N, Rimkeeree H, Mawson A, Chompreeda P, Haruthaithanasan V and Parker M. Antimicrobial activity of cinnamon and clove oils under modified atmosphere conditions. International J. Food Microbiol. 2006; 107 (2): 180-5. [DOI:10.1016/j.ijfoodmicro.2005.07.007]
21. Gende LB, Floris I, Fritz R and Eguaras MJ. Antimicrobial activity of cinnamon (Cinnamomum zeylanicum) essential oil and its main components against Paenibacillus larvae from Argentine. Bulletin of Insectol. 2008; 61 (1): 1.
22. Kędzia A. The activity of cinnamon oil (Oleum Cinnamomi) against anaerobic bacteria. Postępy Fitoterapii. 2011; 1: 1-6.
23. Nabavi SF, Di Lorenzo A, Izadi M, Sobarzo-Sánchez E, Daglia M and Nabavi SM. Antibacterial effects of cinnamon: From farm to food, cosmetic and pharmaceutical industries. Nutrients 2015; 7 (9): 7729-48. [DOI:10.3390/nu7095359]
24. Wang S-Y, Chen P-F and Chang S-T. Antifungal activities of essential oils and their constituents from indigenous cinnamon (Cinnamomum osmophloeum) leaves against wood decay fungi. Bioresource Technol. 2005; 96 (7): 813-8. [DOI:10.1016/j.biortech.2004.07.010]
25. Kędzia A, Ziółkowska-Klinkosz M, Kusiak A, Kochańska B, Kędzia AW and Wojtaszek-Słomińska A. The activity in vitro of cinnamon oil (Oleum Cinnamomi) against yeast like fungi. Postępy Fitoterapii. 2015; (16) 1: 16-20.
26. Park I-K, Park J-Y, Kim K-H, Choi K-S, Choi I-H, Kim C-S and et al. Nematicidal activity of plant essential oils and components from garlic (Allium sativum) and cinnamon (Cinnamomum verum) oils against the pine wood nematode (Bursaphelenchus xylophilus). Nematol. 2005; 7 (5): 767-74. [DOI:10.1163/156854105775142946]
27. Kong J-O, Lee S-M, Moon Y-S, Lee S-G and Ahn Y-J. Nematicidal activity of cassia and cinnamon oil compounds and related compounds toward Bursaphelenchus xylophilus (Nematoda: Parasitaphelenchidae). J. Nematol. 2007; 39 (1): 31.
28. Chao LK, Hua K-F, Hsu H-Y, Cheng S-S, Liu J-Y and Chang S-T. Study on the antiinflammatory activity of essential oil from leaves of Cinnamomum osmophloeum. J. Agricultural and Food Chem. 2005; 53 (18): 7274-8. [DOI:10.1021/jf051151u]
29. Hong J-W, Yang G-E, Kim YB, Eom SH, Lew J-H and Kang H. Anti-inflammatory activity of cinnamon water extract in vivo and in vitro LPS-induced models. BMC Complementary and Alternative Medicine 2012; 12 (1): 237. [DOI:10.1186/1472-6882-12-237]
30. Lu J, Zhang K, Nam S, Anderson RA, Jove R and Wen W. Novel angiogenesis inhibitory activity in cinnamon extract blocks VEGFR2 kinase and downstream signaling. Carcinogenesis 2009; 31 (3): 481-8. [DOI:10.1093/carcin/bgp292]
31. Kwon H-K, Jeon WK, Hwang J-S, Lee C-G, So J-S, Park J-A and et al. Cinnamon extract suppresses tumor progression by modulating angiogenesis and the effector function of CD8+ T cells. Cancer Letters 2009; 278 (2): 174-82. [DOI:10.1016/j.canlet.2009.01.015]
32. Kwon H-K, Hwang J-S, So J-S, Lee C-G, Sahoo A, Ryu J-H and et al. Cinnamon extract induces tumor cell death through inhibition of NFκB and AP1. BMC Cancer 2010; 10 (1): 392. [DOI:10.1186/1471-2407-10-392]
33. Koppikar SJ, Choudhari AS, Suryavanshi SA, Kumari S, Chattopadhyay S and Kaul-Ghanekar R. Aqueous cinnamon extract (ACE-c) from the bark of Cinnamomum cassia causes apoptosis in human cervical cancer cell line (SiHa) through loss of mitochondrial membrane potential. BMC Cancer 2010; 10 (1): 210. [DOI:10.1186/1471-2407-10-210]
34. Mancini-Filho J, Van-Koiij A, Mancini D, Cozzolino F and Torres R. Antioxidant activity of cinnamon (Cinnamomum zeylanicum, Breyne) extracts. Bollettino Chimico Farmaceutico. 1998; 137 (11): 443-7.
35. Shobana S and Naidu KA. Antioxidant activity of selected Indian spices. Prostaglandins, Leukotrienes and Essential Fatty Acids (PLEFA). 2000; 62 (2): 107-10. [DOI:10.1054/plef.1999.0128]
36. Mathew S and Abraham TE. Studies on the antioxidant activities of cinnamon (Cinnamomum verum) bark extracts, through various in vitro models. Food Chem. 2006; 94 (4): 520-8. [DOI:10.1016/j.foodchem.2004.11.043]
37. Mathew S and Abraham TE. In vitro antioxidant activity and scavenging effects of Cinnamomum verum leaf extract assayed by different methodologies. Food and Chemical Toxicol. 2006; 44 (2): 198-206. [DOI:10.1016/j.fct.2005.06.013]
38. Kim N-M, Sung H-S and Kim W-J. Effect of solvents and some extraction conditions on antioxidant activity in cinnamon extracts. Korean Journal of Food Science and Technol. 1993; 25 (3): 204-9.
39. Ross R. The pathogenesis of atherosclerosis: a perspective for the 1990s. Nature. 1993; 362 (6423): 801-9. [DOI:10.1038/362801a0]
40. Maracy MR, Isfahani MT, Kelishadi R, Ghasemian A, Sharifi F, Shabani R and et al. Burden of ischemic heart diseases in Iran, 1990-2010: Findings from the Global Burden of Disease study 2010. J. Research in Medical Sciences:The Official J. Isfahan University of Medical Sciences 2015; 20 (11): 1077. [DOI:10.4103/1735-1995.172832]
41. Members WG, Benjamin EJ, Blaha MJ, Chiuve SE, Cushman M, Das SR and et al. Heart disease and stroke statistics-2017 update: a report from the American Heart Association. Circulation 2017; 135 (10): e146. [DOI:10.1161/CIR.0000000000000491]
42. Duric K, Kovac-Besovic EE, Niksic H, Muratovic S and Sofic E. Anticoagulant activity of some Artemisia dracunculus leaf extracts. Bosnian J. Basic Medical Sciences 2015; 15 (2): 9. [DOI:10.17305/bjbms.2015.384]
43. Paez Espinosa EV, Murad JP and Khasawneh FT. Aspirin: pharmacology and clinical applications. Thrombosis 2011; 2012: 1-15. [DOI:10.1155/2012/173124]
44. Ittaman SV, VanWormer JJ and Rezkalla SH. The role of aspirin in the prevention of cardiovascular disease. Clinical Medicine & Res. 2014; 12 (3-4): 147-54. [DOI:10.3121/cmr.2013.1197]
45. Huang ES, Strate LL, Ho WW, Lee SS and Chan AT. Long-term use of aspirin and the risk of gastrointestinal bleeding. The American J. Medicine 2011; 124 (5): 426-33. [DOI:10.1016/j.amjmed.2010.12.022]
46. Kim SY, Koo YK, Koo JY, Ngoc TM, Kang SS, Bae K and et al. Platelet anti-aggregation activities of compounds from Cinnamomum cassia. J. Medicinal Food 2010; 13 (5): 1069-74. [DOI:10.1089/jmf.2009.1365]
47. Raghavendra R and Naidu KA. Spice active principles as the inhibitors of human platelet aggregation and thromboxane biosynthesis. Prostaglandins, Leukotrienes and Essential Fatty Acids 2009; 81 (1): 73-8. [DOI:10.1016/j.plefa.2009.04.009]
48. Chen S-J, Wang M-H and Chen J. Antiplatelet and calcium inhibitory properties of eugenol and sodium eugenol acetate. General Pharmacology: The Vascular System 1996; 27 (4): 629-33. [DOI:10.1016/0306-3623(95)02089-6]
49. Huang J, Wang S, Luo X, Xie Y and Shi X. Cinnamaldehyde reduction of platelet aggregation and thrombosis in rodents. Thrombosis Res. 2007; 119 (3): 337-42. [DOI:10.1016/j.thromres.2006.03.001]
50. Takenaga M, Hirai A, Terano T, Tamura Y, Kitagawa H and Yoshida S. In vitro effect of cinnamic aldehyde, a main component of Cinnamomi cortex, on human platelet aggregation and arachidonic acid metabolism. J. Pharmacobio-Dynamics 1987; 10 (5): 201-8. [DOI:10.1248/bpb1978.10.201]
51. Yu SM, Wu TS and Teng CM. Pharmacological characterization of cinnamophilin, a novel dual inhibitor of thromboxane synthase and thromboxane A2 receptor. British J. Pharmacol. 1994; 111 (3): 906-12. [DOI:10.1111/j.1476-5381.1994.tb14824.x]
52. Huang J, Luo X, Wang S, Xie Y and Shi X. Effects of cinnamaldehyde on platelet aggregation and thrombosis formation. Chin. J. Clin. Rehabil. 2006; 10: 34-6.
53. Matsuda H, Matsuda R, Fukuda S, Shiomoto H and Kubo M. Anti-thrombic actions of 70% methanolic extract and cinnamic aldehyde from cinnamomi cortex. Chemical and Pharmaceutical Bulletin 1987; 35 (3): 1275-80. [DOI:10.1248/cpb.35.1275]
54. Osende J, Shimbo D, Fuster V, Dubar M and Badimon J. Antithrombotic effects of S 18886, a novel orally active thromboxane A2 receptor antagonist. J. Thrombosis and Haemostasis 2004; 2 (3): 492-8. [DOI:10.1111/j.1538-7933.2004.00639.x]
55. Craig WJ. Health effects of vegan diets. The American J. Clinical Nutrition 2009; 89 (5): 1627S-33S. [DOI:10.3945/ajcn.2009.26736N]
56. Rajaram S. The effect of vegetarian diet, plant foods, and phytochemicals on hemostasis and thrombosis. The American J. Clinical Nutrition 2003; 78 (3): 552S-8S. [DOI:10.1093/ajcn/78.3.552S]
57. Rahman S, Begum H, Rahman Z, Ara F, Iqbal MJ and Yousuf AKM. Effect of cinnamon (Cinnamomum cassia) as a lipid lowering agent on hypercholesterolemic rats. J. Enam Medical College. 2013; 3 (2): 94-8. [DOI:10.3329/jemc.v3i2.16132]
58. Sengsuk C, Sanguanwong S, Tangvarasittichai O and Tangvarasittichai S. Effect of cinnamon supplementation on glucose, lipids levels, glomerular filtration rate, and blood pressure of subjects with type 2 diabetes mellitus. Diabetology International 2016; 7 (2): 124-32. [DOI:10.1007/s13340-015-0218-y]
59. Khadem HH, Farsad NA, Pourghassem GB, Ali AA and Nemati A. Effect of cinnamon supplementation on blood glucose and lipid levels in type2 diabetic patients. Journal of Paramedical Sciences 2011; 1 (2): 2-6.
60. Dugoua J, Perri D, Seely D, Ardilouze J, Ridout R, Bowers K and et al. P02. 123. The anti-diabetic and cholesterol-lowering effects of common and cassia cinnamon (Cinnamomum verum and C. aromaticum): a randomized controlled trial. BMC Complementary and Alternative Medicine 2012; 12 (1): P179. [DOI:10.1186/1472-6882-12-S1-P179]
61. Vafa M, Mohammadi F, Shidfar F, Sormaghi MS, Heidari I, Golestan B and et al. Effects of cinnamon consumption on glycemic status, lipid profile and body composition in type 2 diabetic patients. International J. Preventive Medicine 2012; 3 (8): 531.
62. Mang B, Wolters M, Schmitt B, Kelb K, Lichtinghagen R, Stichtenoth D and et al. Effects of a cinnamon extract on plasma glucose, HbA1c, and serum lipids in diabetes mellitus type 2. European J. Clinical Investigation 2006; 36 (5): 340-4. [DOI:10.1111/j.1365-2362.2006.01629.x]
63. Anderson RA, Broadhurst CL, Polansky MM, Schmidt WF, Khan A, Flanagan VP and et al. Isolation and characterization of polyphenol type-A polymers from cinnamon with insulin-like biological activity. J. Agricultural and Food Chem. 2004; 52 (1): 65-70. [DOI:10.1021/jf034916b]
64. Wang N and Tall AR. Cholesterol in platelet biogenesis and activation. Blood 2016; 127 (16): 1949-53. [DOI:10.1182/blood-2016-01-631259]
65. Sener A, Ozsavci D, Oba R, Demirel GY, Uras F and Yardimci KT. Do platelet apoptosis, activation, aggregation, lipid peroxidation and platelet-leukocyte aggregate formation occur simultaneously in hyperlipidemia? Clinical Biochem. 2005; 38 (12): 1081-7. [DOI:10.1016/j.clinbiochem.2005.09.005]
66. Chan L, Luo X, Ni H, Shi H, Liu L, Wen Z and et al. High levels of LDL-C combined with low levels of HDL-C further increase platelet activation in hypercholesterolemic patients. Brazilian J. Medical and Biological Res. 2015; 48 (2): 167-73. [DOI:10.1590/1414-431x20144182]
67. Korporaal SJ and Akkerman J-WN. Platelet activation by low density lipoprotein and high density lipoprotein. Pathophysiology of Haemostasis and Thrombosis 2006; 35 (3-4): 270-80. [DOI:10.1159/000093220]
68. Korporaal SJ, Van Eck M, Adelmeijer J,Ijsseldijk M, Out R, Lisman T and et al. Platelet activation by oxidized low density lipoprotein is mediated by CD36 and scavenger receptor-A. Arteriosclerosis, Thrombosis, and Vascular Biol. 2007; 27 (11): 2476-83. [DOI:10.1161/ATVBAHA.107.150698]
69. Podrez EA, Byzova TV, Febbraio M, Salomon RG, Ma Y, Valiyaveettil M and et al. Platelet CD36 links hyperlipidemia, oxidant stress and a prothrombotic phenotype. Nature Medicine 2007; 13 (9): 1086-95. [DOI:10.1038/nm1626]
70. Shattil S, Anaya-Galindo R, Bennett J, Colman RW and Cooper R. Platelet hypersensitivity induced by cholesterol incorporation. J. Clinical Investigation. 1975; 55 (3): 636. [DOI:10.1172/JCI107971]
71. Khan SH and Ahmad SA. Relationship between platelet indices and lipidemias: A cross-sectional study at Karachi. Journal of Postgraduate Medical Institute (Peshawar-Pakistan). 2014; 28 (2): 121-127.
72. Kang H, Park S-H, Yun J-M, Nam T-G, Kim Y-E, Kim D-O and et al. Effect of cinnamon water extract on monocyte-to-macrophage differentiation and scavenger receptor activity. BMC Complementary and Alternative Medicine 2014; 14 (1): 90. [DOI:10.1186/1472-6882-14-90]

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