year 12, Issue 46 (5-2013)                   J. Med. Plants 2013, 12(46): 170-176 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Mohammadi S, Fallah huseini H, Afkhami Ardacani M, Salami M, Bolurani S. Effects of Silymarin on Insulin Resistance and Blood Lipid Profile in First-degree Relatives of Type 2 Diabetic Patients. J. Med. Plants 2013; 12 (46) :170-176
1- Department of Internal Medicine, Shahid Sadoughi University of Medical Science
2- Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR
3- Department of Internal Medicine, Shahid Sadoughi University of Medical Science ,
Abstract:   (6420 Views)
Background: Diabetes mellitus is a metabolic disorder that is characterized by hyperglycemia due to insulin deficiency or cellular resistance. Silymarin is an effective agent that reduces cell resistance to insulin and improves lipid profile. Objective: In this study the effects of silymarin on insulin resistance and blood lipid profile in first-degree relatives of type 2 diabetic patients were evaluated. Methods: This randomized clinical trial was performed on first-degree relatives of type 2 diabetic patients (n=60) with BMI above 25 kg/m2. After completing questionnaire and obtaining written consent, participants were randomly assigned to give placebo or silymarin group. The patients in silymarin group received two 140 mg capsules of silymarin daily and placebo group 140 mg placebo capsules similarly for 12 weeks. Fasting blood glucose, HbA1c, cholesterol, triglyceride, and LDL, HDL, insulin and 2hpp blood glucose level were determined before and after the study. Results: In silymarin treated group, insulin resistance and serum insulin level were reduced significantly (p < 0.05) compared with beginning as well as compared with placebo group. The blood glucose level and lipid profile didn’t change significantly after silymarin therapy compared with placebo group. Conclusion: According to our results silymarin positively influence insulin resistance and insulin level in first-degree relatives of type 2 diabetic patients but its effect on lipid profile need further studies.
Full-Text [PDF 207 kb]   (2433 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2015/01/29 | Accepted: 2013/07/14 | Published: 2013/07/22

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb