year 9, Issue 33 And S6 (supplement 6 2010)                   J. Med. Plants 2010, 9(33 And S6): 86-96 | Back to browse issues page

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Ahmadi-Ashtiani H, Rezazadeh S, Barkhordari E, Hekmat-Nazemi N, Baghaei M, Bokaie S et al . Evaluation of Protective Effects of Nano-formulated Silymarin Against UV Radiation on Guinea Pig Skin. J. Med. Plants 2010; 9 (33) :86-96
1- Department of Clinical Biochemistry, School of Medical Science, Tarbiat-e-Modarres University, Tehran, Iran & Biochemistry and Nutrition Department, Zanjan University of Medical Sciences, Zanjan
2- Institute of Medicinal Plants, ACECR, Tehran
3- Tehran University of Medical Science, Tehran
4- Cosmetics Industry Researcher, Tehran
5- Faculty of Veterinary, University of Tehran, Tehran
6- Ministry of Health and Medical Education, Food & Drug Laboratory Research Center, Tehran ,
Abstract:   (4245 Views)

Background: As increased outdoor activities of people, they are more exposed to UV radiation, which causes harmful effects on skin. Silymarin has protective potentials against DNA damage and non-melanoma skin cancers, and also it has anti-oxidant, anti-inflammatory, and immune regulation characteristics. Nano formulation of plant material showed to be more effective than common ones.

Objective: In present study, nano-formulated silymarin was used in a cream, and its effects were investigated against destructive effects of UV rays.

Methods: Silymarin standardized extract was prepared, nano formulated in cream base, and applied to skin of the animals. Four groups of animals (n=15) were examined Group 1 without any treatment (control), Group 2 Vaseline, Group 3 nano-formulated silymarin extract cream, and Group 4 silymarin-carnosine. UV was radiated on the shaved area of the four groups for 45 minutes with dose of 180 mJ/cm2. Dermal scaling, skin irregularity, erythema, skin hyperpigmentation, and edema were evaluated in animals. Histopathological observation was done on the skin samples of the animals.

Results: silymarin nano-formulation was effective in decreasing both physical damages and histopathological injuries significantly.

Conclusion: from the observed results, it can be concluded that the cream containing nano-formulated silymarin can prevent UV radiation lesions better than pure silymarin.
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Type of Study: Research | Subject: Medicinal Plants
Received: 2009/11/15 | Accepted: 2010/03/8 | Published: 2010/03/19

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