سال 9، شماره 33 و S6 - ( supplement 6 1388 )                   سال 9 شماره 33 و S6 صفحات 96-86 | برگشت به فهرست نسخه ها

XML English Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Ahmadi-Ashtiani H, Rezazadeh S, Barkhordari E, Hekmat-Nazemi N, Baghaei M, Bokaie S et al . Evaluation of Protective Effects of Nano-formulated Silymarin Against UV Radiation on Guinea Pig Skin. J. Med. Plants. 2010; 9 (33) :86-96
URL: http://jmp.ir/article-1-518-fa.html
احمدی آشتیانی حمیدرضا، رضازاده شمسعلی، برخورداری ، حکمت نظامی ، بقایی ، بکایی و همکاران.. Evaluation of Protective Effects of Nano-formulated Silymarin Against UV Radiation on Guinea Pig Skin. فصلنامه گياهان دارویی. 1388; 9 (33) :96-86

URL: http://jmp.ir/article-1-518-fa.html


1- Department of Clinical Biochemistry, School of Medical Science, Tarbiat-e-Modarres University, Tehran, Iran & Biochemistry and Nutrition Department, Zanjan University of Medical Sciences, Zanjan
2- Institute of Medicinal Plants, ACECR, Tehran
3- Tehran University of Medical Science, Tehran
4- Cosmetics Industry Researcher, Tehran
5- Faculty of Veterinary, University of Tehran, Tehran
6- Ministry of Health and Medical Education, Food & Drug Laboratory Research Center, Tehran ، mh_rastegar@yahoo.com
چکیده:   (3836 مشاهده)

Background: As increased outdoor activities of people, they are more exposed to UV radiation, which causes harmful effects on skin. Silymarin has protective potentials against DNA damage and non-melanoma skin cancers, and also it has anti-oxidant, anti-inflammatory, and immune regulation characteristics. Nano formulation of plant material showed to be more effective than common ones.

Objective: In present study, nano-formulated silymarin was used in a cream, and its effects were investigated against destructive effects of UV rays.

Methods: Silymarin standardized extract was prepared, nano formulated in cream base, and applied to skin of the animals. Four groups of animals (n=15) were examined Group 1 without any treatment (control), Group 2 Vaseline, Group 3 nano-formulated silymarin extract cream, and Group 4 silymarin-carnosine. UV was radiated on the shaved area of the four groups for 45 minutes with dose of 180 mJ/cm2. Dermal scaling, skin irregularity, erythema, skin hyperpigmentation, and edema were evaluated in animals. Histopathological observation was done on the skin samples of the animals.

Results: silymarin nano-formulation was effective in decreasing both physical damages and histopathological injuries significantly.

Conclusion: from the observed results, it can be concluded that the cream containing nano-formulated silymarin can prevent UV radiation lesions better than pure silymarin.
واژه‌های کلیدی: Nano-formulation، Silymarin، UV protection، Guinea Pig
متن کامل [PDF 374 kb]   (1282 دریافت)    
نوع مطالعه: پژوهشی | موضوع مقاله: گياهان دارویی
دریافت: 1388/8/24 | پذیرش: 1388/12/17 | انتشار: 1388/12/28

ارسال نظر درباره این مقاله : نام کاربری یا پست الکترونیک شما:
CAPTCHA

ارسال پیام به نویسنده مسئول


بازنشر اطلاعات
Creative Commons License این مقاله تحت شرایط Creative Commons Attribution-NonCommercial 4.0 International License قابل بازنشر است.

کلیه حقوق این وب سایت متعلق به فصلنامه علمی پژوهشی گیاهان دارویی می باشد.

طراحی و برنامه نویسی : یکتاوب افزار شرق

© 2022 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb