year 7, Issue 25 (2-2008)                   J. Med. Plants 2008, 7(25): 12-20 | Back to browse issues page

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Mokhtari M, Shariatie M, Gharamanie R. Effect of Trigonella foenum-graecum L. Seed Extract on Concentration of Testosterone and Spermatogenesis in Rats. J. Med. Plants 2008; 7 (25) :12-20
1- Department of Biology, Islamic Azad University Kazeroun Branch, Iran ,
2- Department of Biology, Islamic Azad University Kazeroun Branch, Iran
Abstract:   (10944 Views)
Background: Overpopulation is a global problem with grave implication for the future. There is evidence of broad increase of plants accessible and useful which potentially could be anti-fertility and regulate the reproduction in males. Despite the vast use of Trigonella foenum-graecum in daily lives, our knowledge of its effect on testicular function is very limited. So, the need for a careful study of potential have been found in order to minimize the problem. In the present study T. foenum-graecum is warranted. The present study aims at investigating the effect of T. foenum-graecum seed extract on concentration of testosterone and spermataogenesis in rat. The implication of this study could be helpful for family planning and fertility. Method: Fifty rats were divided into five groups including control, sham and experimcntal groups. Each of the rats in experimental group was treated orally with 50, 100 and 150 /mg dose of T. foenum-graecum extract for fourteen days. The sham group received distilled water and the rats without administered T. foenum-graecum extract or distilled water were considered as control group. After fourteen days, the blood sample from each rat was collected and concentrations of FSH, LH and testosterone hormones were measured. Furthermore, the sample tissue of testis and epididymis from each rate were collected and histological study was carried out to achieve maximum information concerning the change of the testis and epididymis tissue between experimental and control groups. The results obtained from this study were statisticlly analysed using ANOVA and Tukey test. Results: The result of the study indicated that the concentrations of LH and testosterone in experimental groups relatively reduced in comparison with control group (p0.05). Conclusion: According to several reports and our findings trigonella seed extract contains sapogenin and diosgenin, which are precursor of progesterone and have anti gonadoterpine and antiandrogeni character. Hence, they have the capability to reduce the concentration of testosterone and LH hormones. The results of histological studies revealed that morphological changes in seminiferous tubules and atrophy of leydig cells and epididymis.
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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2006/12/16 | Accepted: 2007/10/5 | Published: 2008/05/18

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