year 1, Issue 1 (3-2002)                   J. Med. Plants 2002, 1(1): 1-10 | Back to browse issues page

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Hosseinzadeh H, Khoei A, Jafari M, Ghasamipour J. Antihypoxic, anti-ischemic and acute toxicity effect of Salvia leriifolia Benth. root in mice and rats. J. Med. Plants. 2002; 1 (1) :1-10
1- Pharmaceutical Sciences Rescarch Center and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran ,
2- School of Medicine, Mashhad University of Medical Sciences, Mashhad, Iran
3- Bu-Ali Research Institute and School of Pharmacy, Mashhad University of Medical Sciences, Mashhad, Iran
4- Pharmacist
Abstract:   (3568 Views)
The antihypoxic effect Salvia leriifolia root aqueous and ethanolic extracts was studied using hypoxia creating in a tightly glass container in mice. Ischemia was induced using four-vessel occlusion model and evaluated by optical and transmission electrinic microscope in rats. The extract of S. leriifolia showed antihypoxic effect and the minimum effective dose was 0.7 g/kg. In ischemic rat, the aqueous and ethanolic extracts significantly reduced neural cell injury in CA1 and CA3, 4 hippocampus rats. LD50 values (i.p, mice) of the aqueous and the ethanolic extracts were 1.45 g/kg and 1.55 g/kg, respectively. Both extracts comprised saponins and tannins. These results indincate that the extracts of S. leriifolia root have protective effect against hypoxia and ischemia.
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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2001/05/17 | Accepted: 2002/02/12 | Published: 2002/03/15

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