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Agajani Delavar M, Nasiri F, Hoseini S. A double-blind placebo-controlled evaluation of Vitex agnus castus in premenstrual syndrome. J. Med. Plants 2002; 1 (2) :15-20
URL: http://jmp.ir/article-1-810-en.html

The objective of this study was evaluation of Vitex agnus castus) VACS) extract in alleviation of symptoms of premenstrual syndrome. The study was designed as double blind placebo controlled in two parallels groups (each 15 patients). Treatment phase lasted 3 consequent menstrual cycles (2 * 30 drops/ day =1.8 ml of VACS) or placebo. For assessment of the efficacy, visual analogue scale was used. Altogether 20 patients were included into the stastiscal analysis (each 10 patients). Good response of mental Symptoms to treatment was 70% for Vitex Compared to 30% for placebo. Seventy percent of women showed a great than 50% improvement in score compared with only 40% of taking placebo. Our results suggest a beneficial effect of Vitex in the treatment of PMS.