year 12, Issue 47 (9-2013)                   J. Med. Plants 2013, 12(47): 62-69 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Fallah Huseini H, Kianbakht S, Hoormand M. Protective Effects of Vaccinium arctostaphylos L., Berberis thunbergii var. atropurpurea Chenault, Elaeagnus angustifolia L. and Launaea acanthodes (Boiss.) O. Kuntze against Indomethacin-Induced Gastric Ulcers in Rats. J. Med. Plants 2013; 12 (47) :62-69
1- Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR
2- Pharmacology & Applied Medicine Department of Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR ,
Abstract:   (4683 Views)
Background: Data suggest that V. arctostaphylos, B. thunbergii var. atropurpurea, E. angustifolia and L. acanthodes may prevent gastric ulcers induced by Non-steroidal anti-inflammatory drugs (NSAIDs). Objective: To explore the ulcer-protective potential of these plants in indomethacin-induced gastric ulcers in rats. Methods: Saline, hydro-alcoholic extract of each plant (100, 400, 800 mg/kg) and omeprazole (30 mg/kg) were gavaged to the groups of animals for 4 consecutive days. Gastric ulcers were induced by the onetime gavage of indomethacin (30 mg/kg, p.o.). On the fifth day, each group was pretreated with physiological saline as control, extract (100, 400 or 800 mg/kg, p.o.) or omeprazole (30 mg/kg, p.o.) 30 min before the indomethacin administration. The animals were killed 6 h after the indomethacin administration. The stomachs were removed, opened along the greater curvature and washed in physiological saline. A person unaware of the type of treatment received by the animals examined the stomachs under a 3-fold magnifier. The areas and lengths of hemorrhagic lesions induced by indomethacin were measured using a dial caliper and the sum of measurements for each animal was referred to as the ulcer index. Results: All extracts reduced the ulcer index significantly compared to the control group (p < 0.05). Conclusion: These plants prevent NSAID-induced gastric ulcers in rats. The efficacy and potency of the gastro-protective effect of L. acanthodes appears to be higher than the other 3 plants.
Full-Text [PDF 143 kb]   (1749 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2013/06/12 | Accepted: 2013/09/14 | Published: 2013/10/22

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb