Volume 5 - Supplement 2 diabetes                   J. Med. Plants 2006, 5 - Supplement 2 diabetes: 42-47 | Back to browse issues page

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Roghani M, Baluchnejadmojarad T. Time-dependent changes in responsiveness of thoracic aorta of diabetic rats to quercetin. J. Med. Plants 2006; 5 (S2) :42-47
URL: http://jmp.ir/article-1-601-en.html
1- Department of Physiology, School of Medicine, Shahed University and Medicinal plant research center, Tehran , mehjour@yahoo.com
2- Department of Physiology, School of Medicine, Iran University of Medical sciences, Tehran
Abstract:   (6152 Views)

Background and Objective: Cardiovascular disorders are amongst the most prevalent complications of diabetes mellitus in long term. Since vascular responsiveness to vasoactive agents changes in diabetes with time, this experimental study was conducted to evaluate time-dependent changes in the responsiveness of thoracic aorta of diabetic rats to the flavonoid quercetin.

Methods: For this purpose, male wistar rats were divided into control and experimental groups. For induction of diabetes, streptozotocin (i.p.) was used. The body weight and serum glucose parameters were determined before and at 2nd, 4th, and 8th weeks after the experiment. Contractile responsiveness to KCl and noreadrenalin (NA) and quercetin-induced vasorelaxation were measured at 4th and 8th weeks.

Results: The results showed that after 4 and 8 weeks, quercetin (0.1 μM-1 mM) induced a dose-dependent vasorelaxation in aortic rings precontracted with KCl and/or NA from both control and diabetic groups. Furthermore, this vasorelaxation was significantly attenuated in diabetic group eight weeks after the study in comparison with data at fourth week.

Conclusion: It can be concluded that the vasorelaxant effect of this flavonoid is attenuated in diabetes mellitus with time.

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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2005/01/18 | Accepted: 2005/07/26 | Published: 2006/02/19

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