year 7, Issue 28 (11-2008)                   J. Med. Plants 2008, 7(28): 112-119 | Back to browse issues page

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Asgary S, Movahedian A, Badiee A, Naderi G, Amini F, Hamidzadeh Z. Effect of Gundelia tournefortii L. on Some Cardiovascular Risk Factors in Animal Model. J. Med. Plants 2008; 7 (28) :112-119
1- Isfahan Cardiovascular Research Center, Applied Physiology Research Center Isfahan, Isfahan University Of Medical Sciences, Iran ,
2- Isfahan University Of Medical Sciences, Isfahan, Iran
3- Isfahan Cardiovascular Research Center, Isfahan, Iran
Abstract:   (6692 Views)
Background: There is no certain result in the field of industrial pharmacy approaching to find effective drugs in prevention and treatment of atherosclerosis, like the control of lipid factors that are a major risk factors of atherosclerosis. Also the tendency of people to use herbal medicine is increasing. Objective: In this study effect of Gundelia tourenfortii L. on some cardiovascular risk factors in animal model assigned by analysis of biochemical factors. Methods: Twenty male rabbits were randomly divided in to 4 groups as: Normal diet, Normal diet supplemented with Gundelia tourenfortii L., high cholesterol diet, and high cholesterol diet supplemented with Gundelia tourenfortii L. Fasting Blood samples were taken at the first and end of the study. Results: Gundelia tourenfortii L. decrease the cholesterol, triglyceride, LDL - cholesterol, VLDL-Cholesterol, apolipoprotein B, oxidized LDL and factor VII. Also increase the level of HDL-Cholesterol and apolipoprotein A comparing to high cholesterol diet. Conclusion: Gundelia tourenfortii L. by decreasing lipid, lipoproteins and some cardiovascular new risk factors like apolipoprotein B, Oxidized-LDL and coagulation factor decrease atherosclerosis.
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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2007/06/15 | Accepted: 2008/09/15 | Published: 2008/12/20

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