year 24, Issue 96 (1-2026)
J. Med. Plants 2026, 24(96): 53-67 |
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Research code: 1393-03-98-1842
Ethics code: 1393-03-98-1842
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Zarei, Hosseini N, Ramezani M, Alimoradian A, Changizi-Ashtiyani S. Hepatoprotective and hypolipidemic effects of Hibiscus gossypifolius, Trachyspermum copticum, Taraxacum officinale, and Rosmarinus officinalis extracts in a rat model of diet-induced hypercholesterolemia. J. Med. Plants 2026; 24 (96) :53-67
URL: http://jmp.ir/article-1-3945-en.html
URL: http://jmp.ir/article-1-3945-en.html
1- Department of Physiology, Estahban School of Paramedical Sciences, School of Nursing Hazrat Zahra (P.B.U.H) Abadeh, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Medicinal Plants, Faculty of Agriculture and Natural Resources, Arak University, Arak, Iran
3- Department of Internal Medicine, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Pharmacology, School of Medicine, Arak University of Medical Sciences, Arak, Iran
5- Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran ,ashtiyani@yahoo.com
2- Department of Medicinal Plants, Faculty of Agriculture and Natural Resources, Arak University, Arak, Iran
3- Department of Internal Medicine, School of Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran; Endocrinology and Metabolism Research Center, Endocrinology and Metabolism Clinical Sciences Institute, Tehran University of Medical Sciences, Tehran, Iran
4- Department of Pharmacology, School of Medicine, Arak University of Medical Sciences, Arak, Iran
5- Department of Physiology, School of Medicine, Iran University of Medical Sciences, Tehran, Iran ,
Abstract: (12 Views)
Background: Hypercholesterolemia is a key risk factor for cardiovascular and metabolic diseases, prompting the search for natural alternatives with fewer side effects than conventional drugs such as orlistat. Objective: This study aimed to comparatively evaluate the hepatoprotective and hypolipidemic efficacy of hydroalcoholic extracts from H. gossypifolius, Trachyspermum copticum, Taraxacum officinale, and Rosmarinus officinalis in a rat model of diet-induced hypercholesterolemia. Methods: Fifty-six male Wistar rats were allocated into seven groups (n= 8). Groups received either a standard diet, a high-cholesterol diet (HCD; 2 % cholesterol) with saline, or the HCD supplemented via daily gavage with orlistat (10 mg/kg) or one of the plant extracts (500, 800, 200, 300 mg/kg, respectively) for 48 days. Biochemical parameters, including lipid profile, liver enzymes, and renal markers, were analyzed. Results: The extracts demonstrated distinct therapeutic specializations. T. officinale was the most effective in reducing body weight gain. T.copticum and R. officinalis showed superior hepatoprotective effects, significantly lowering AST, and ALT/ALP levels, respectively. Contrary to the initial hypothesis, none of the plant extracts reduced LDL or total cholesterol more effectively than the HCD-control; orlistat was the most effective hypolipidemic agent. R. officinalis showed a non-significant trend towards reducing creatinine levels. Conclusion: This study shows the investigated plant extracts have specific, complementary effects. T. officinale potently reduces weight gain, whereas T. copticum and R. officinalis provide significant hepatoprotection. However, these extracts did not show superior hypolipidemic efficacy compared to the control, a finding that requires further study. The potential of these plants for weight management and liver protection merits future research with standardized extracts.
Keywords: Hibiscus gossypifolius, Rosmarinus officinalis, Taraxacum officinale, Trachyspermum copticum, Hypercholesterolemia, Medicinal Plants
Type of Study: Research |
Subject:
Pharmacognosy & Pharmaceutics
Received: 2025/06/29 | Accepted: 2025/12/22 | Published: 2026/01/30
Received: 2025/06/29 | Accepted: 2025/12/22 | Published: 2026/01/30
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