year 24, Issue 93 (5-2025)
J. Med. Plants 2025, 24(93): 1-11 |
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Bayat M, Jamshidi A, Mohammadi-Kenari H, Ghobadi A. Barberry (Berberis L.) as a functional food and therapeutic agent in traditional persian medicine and modern phytotherapy: a narrative review. J. Med. Plants 2025; 24 (93) :1-11
URL: http://jmp.ir/article-1-3735-en.html
URL: http://jmp.ir/article-1-3735-en.html
1- School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Institute for Studies in Medical History, Persian and Complementary Medicine &School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
3- School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran ,ghobadi.a@iums.ac.ir
2- Institute for Studies in Medical History, Persian and Complementary Medicine &School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
3- School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran ,
Abstract: (165 Views)
Background: Barberry (Berberis L.) is a well-known fruit traditionally used in various ethnomedical systems, including Ayurveda and Traditional Persian Medicine (TPM), for its nutritionaland therapeutic properties. Objective: This study aims to provide a comprehensive overview of the traditional medicinal uses, phytochemical composition, and pharmacological effects of barberry. Method: A systematic review was conducted by examining traditional Persian medicine texts and electronic literature on traditional medicine. Additionally, electronic databases were searched for scholarly articles focusing on the pharmacological activities and phytochemical components of barberry. Results: Phytochemical analysis revealed the presence of essential oils, micronutrients, macronutrients, phytosterols, and various phenolic compounds. Pharmacological studies demonstrate that barberry possesses diverse biological activities, including anti-cancer, antioxidant, cardiometabolic protective, antimicrobial, hepatoprotective, anti-inflammatory, anxiolytic, nootropic, and neuroprotective effects. Conclusion: Although barberry shows promising therapeutic potential, further clinical trials and meta-analyses are required to confirm its efficacy in medical applications.
Type of Study: Review |
Subject:
Medicinal Plants
Received: 2024/09/14 | Accepted: 2024/12/11 | Published: 2025/05/14
Received: 2024/09/14 | Accepted: 2024/12/11 | Published: 2025/05/14
References
1. Nasri H, Baradaran A, Shirzad H and Rafieian-Kopaei M. New concepts in nutraceuticals as alternative for pharmaceuticals. IJPM. 2014; 5(12): 1487-99.
2. Keservani RK, Kesharwani RK, Vyas N, Jain S, Raghuvanshi R and Sharma AK. Nutraceutical and functional food as future food: A review. Der. Pharmacia. Lettre. 2010; 2(1): 106-16.
3. Karimi Z, Firouzi M, Dadmehr M, Javad‐Mousavi SA, Bagheriani N and Sadeghpour O. Almond as a nutraceutical and therapeutic agent in persian medicine and modern phytotherapy: A narrative review. Phytother. Res. 2021; 35(6): 2997-3012. [DOI:10.1002/ptr.7006]
4. Farhadi Chitgar M, Aalami M, Maghsoudlou Y and Milani E. Comparative study on the effect of heat treatment and sonication on the quality of barberry (Berberis vulgaris) juice. JFPP. 2017; 41(3): e12956. [DOI:10.1111/jfpp.12956]
5. Aghbashlo M, Kianmehr MHand Hassan-Beygi SR. Specific heat and thermal conductivity of berberis fruit (Berberis vulgaris). AJABSSP. 2008; 3(1): 330-6. [DOI:10.3844/ajabssp.2008.330.336]
6. Birdsall TC and Kelly GS. Berberine: Therapeutic potential of an alkaloid found in several medicinal plants. Alt Med. Rev. 1997; 2(2): 94-103.
7. Kang J, Kang Y, Ji X, Guo Q, Jacques G, Pietras M, Łuczaj N, Li D and Łuczaj Ł. Wild food plants and fungi used in the mycophilous Tibetan community of Zhagana (Tewo County, Gansu, China). JEE. 2016; 12: 1-13. [DOI:10.1186/s13002-016-0094-y]
8. Tavakoli A, Sahari MA and Barzegar M. Antioxidant activity of Berberis integerrima seed oil as a natural antioxidant on the oxidative stability of soybean oil. IJFP. 2017; 20(Sup3): 1-12. [DOI:10.1080/10942912.2017.1382509]
9. Aliakbarlu J, Mohammadi S and Khalili S. A study on antioxidant potency and antibacterial activity of water extracts of some spices widely consumed in Iranian diet. JFB. 2013; 38(2): 159-66. [DOI:10.1111/jfbc.12034]
10. Rahimi-Madiseh M, Lorigoini Z, Zamani-Gharaghoshi H and Rafieian-Kopaei M. Berberis vulgaris: Specifications and traditional uses. Iran. J. Basic Med. Sci. 2017; 20(5): 569-587.
11. Salehi B, Selamoglu Z, Sener B, Kilic M, Kumar Jugran A, de Tommasi N and Cho WC. Fs. Berberis plants-Difting from farm to food applications, phytotherapy, and phytopharmacology. Foods 2019; 8(10): 522. [DOI:10.3390/foods8100522]
12. Khorasani Shirazi AA. Makhzan al-Adwyah. Tehran: University of Tehran Press. 2008, pp: 392-398.
13. Sun W, Shahrajabian MH and Cheng Q. Barberry (Berberis vulgaris), a medicinal fruit and food with traditional and modern pharmaceutical uses. Israel Journal of Plant Sciences 2021; 68(1-2): 1-11. [DOI:10.1163/22238980-bja10019]
14. Imanshahidi M and Hosseinzadeh H. Pharmacological and therapeutic effects of Berberis vulgaris and its active constituent, berberine. Phytother. Res. 2008; 22(8): 999-1012. [DOI:10.1002/ptr.2399]
15. Xu X, Yi H, Wu J, Kuang T, Zhang J, Li Q, Du H, Xu T, Jiang G and Fan G. Therapeutic effect of berberine on metabolic diseases: Both pharmacological data and clinical evidence. Biomed Pharmacother. 2021; 133: 110984. [DOI:10.1016/j.biopha.2020.110984]
16. Safari Z, Farrokhzad A, Ghavami A, Fadel A, Hadi A, Rafiee S, Mokari-Yamchi A and Askari GR. The effect of Barberry (Berberis vulgaris L.) on glycemic indices: A systematic review and meta-analysis of randomized controlled trials. Complement. Ther. Med. 2020; 51: 102414. [DOI:10.1016/j.ctim.2020.102414]
17. Roshanravan B, Yousefizadeh S, Apaydin Yildirim B, Farkhondeh T, Amirabadizadeh A, Ashrafizadeh M, Talebi M and Saeed Samarghandian S. The effects of Berberis vulgaris L. and Berberis aristata L. in metabolic syndrome patients: a systematic and meta-analysis study. Arch. Physiol. Biochem. 2023; 129(2): 393-404. [DOI:10.1080/13813455.2020.1828482]
18. Shakeri F, Kiani S, Rahimi G and Boskabady MH. Anti‐inflammatory, antioxidant, and immunomodulatory effects of Berberis vulgaris and its constituent berberine, experimental and clinical, a review. Phytother. Res. 2024; 38(4): 1882-1902. [DOI:10.1002/ptr.8077]
19. Hanachi P and Golkho SH. Using HPLC to determination the composition and antioxidant activity of Berberis sp. Europ. J. Scientific Res. 2009; 29(1): 47-54.
20. Hassan HF and Najim ZK. Antileishmanial effect of berberine and extracts of Berberis vulgaris on the growth of leishmanial species. IJPQA. 2020; 11(02): 237-241. [DOI:10.25258/ijpqa.11.2.8]
21. Khorasani A. Makhzan al-Adwyah. Iran. Aghili Khorasani, S. H. M. Tehran: University of Tehran Press. 2008, 422-429.
22. Han Y, Guo S, Li Y, Li J, Zhu L, Liu Y, Lv Y, Yu D, Zheng L, Huang C, Li Ch, Hu J and Liu Z. Berberine ameliorate inflammation and apoptosis via modulating PI3K/AKT/NFκB and MAPK pathway on dry eye. Phytomedicine. 2023; 121: 155081. [DOI:10.1016/j.phymed.2023.155081]
23. Och A, Lemieszek MK, Cieśla M, Jedrejek D, Kozłowska A, Pawelec S and Nowak R. Berberis sp. L. Root extract as a multi-target chemopreventive agent against colon cancer causing apoptosis in human colon adenocarcinoma cell lines. IJMS. 2024; 25(9): 4786. [DOI:10.3390/ijms25094786]
24. Tahmasebi L, Zakerkish M, Golfakhrabadi F and Namjoyan F. Randomised clinical trial of Berberis vulgaris root extract on glycemic and lipid parameters in type 2 diabetes mellitus patients. EUJIM. 2019; 32: 100998. [DOI:10.1016/j.eujim.2019.100998]
25. Emamat H, Zahedmehr A, Asadian S, Tangestani H and Nasrollahzadeh J. Effect of barberry (Berberis vulgaris) consumption on blood pressure, plasma lipids, and inflammation in patients with hypertension and other cardiovascular risk factors: study protocol for a randomized clinical trial. Trials 2020; 21: 986, 1-9. [DOI:10.1186/s13063-020-04918-7]
26. El-Zahar KM, Al-Jamaan ME, Al-Mutairi FR, Al-Hudiab AM, Al-Einzi MS and Mohamed AA-Z. Antioxidant, antibacterial, and antifungal activities of the ethanolic extract obtained from Berberis vulgaris roots and leaves. Molecules 2022; 27(18): 6114. [DOI:10.3390/molecules27186114]
27. Dabaghzadeh F, Sharififar F, Ahmadzadeh A-M and Karami-Mohajeri S. The effects of Berberis vulgaris L. root extract on the opiate withdrawal syndrome and psychological factors: a randomized double-blind clinical trial. JBCPP. 2023; 34(4): 465-72. [DOI:10.1515/jbcpp-2020-0327]
28. Amini MR, Sheikhhossein F, Naghshi S, Djafari F, Askari M, Shahinfar H, Safabakhsh M and Alireza Jafari AR. Effects of berberine and barberry on anthropometric measures: A systematic review and meta-analysis of randomized controlled trials. Complement Ther. Med. 2020; 49: 102337. [DOI:10.1016/j.ctim.2020.102337]
29. Naghibi Z, Rakhshandeh H, Jarahi L, Hosseini SM and Yousefi M. Evaluation of the effects of additional therapy with Berberis vulgaris oxymel in patients with refractory primary sclerosing cholangitis and primary biliary cholangitis: A quasi-experimental study. Avice. J. Phytomed. 2021; 11(2): 154-167.
30. Akbulut M, ÇALIŞIR S, Marakoglu T and COklar H. Some physicomechanical and nutritional properties of barberry (Berberis vulgaris L.) fruits. JFPE. 2009; 32(4): 497-511. [DOI:10.1111/j.1745-4530.2007.00229.x]
31. Mokhber-Dezfuli N, Saeidnia S, Gohari AR and Kurepaz-Mahmoodabadi M. Phytochemistry and pharmacology of Berberis species. Pharmacogn. Rev. 2014; 8(15): 8-15. [DOI:10.4103/0973-7847.125517]
32. Imenshahidi M and Hosseinzadeh H. Berberis vulgaris and Berberine: an update review. Phytother. Res. 2016; 30(11): 1745-64. [DOI:10.1002/ptr.5693]
33. Kermani T, Kazemi T, Molki S, Ilkhani K, Sharifzadeh GR. The effect of Berberis vulgaris (Barberry fruit) on a component of metabolic syndrome: a randomized clinical trial. Modern Care Journal. 2020; 17(2). e93955. [DOI:10.5812/modernc.93955]
34. Emamat H, Asadian S, Zahedmehr A, Ghanavati M and Nasrollahzadeh J. The effect of barberry (Berberis vulgaris) consumption on flow‐mediated dilation and inflammatory biomarkers in patients with hypertension: A randomized controlled trial. Phytother. Res. 2020; 35(5): 2607-15. [DOI:10.1002/ptr.7000]
35. Rostami H, Babaali F, Moradi L, Golfakhrabadi F, Abdi L. Evaluation of the effect of barberry root (Berberis vulgaris) on the prevention of metabolic syndrome caused by atypical antipsychotic drugs in patients with schizophrenia: a three-blind placebo-controlled clinical trial. Iran. J. Psychiatry. 2023; 18(3): 362. [DOI:10.18502/ijps.v18i3.13015]
36. Lazavi F, Mirmiran P, Sohrab G, Nikpayam O, Angoorani P, Hedayati M. The barberry juice effects on metabolic factors and oxidative stress in patients with type 2 diabetes: a randomized clinical trial. Complement. Ther. Clin. Pract. 2018; 31: 170-4. [DOI:10.1016/j.ctcp.2018.01.009]
37. Rashidi H, Namjoyan F, Mehraban Z, Zakerkish M, Ghaderian SB and Latifi S. The effects of active ingredients of barberry root (Berberine) on Glycemic control and insulin resistance in type 2 diabetic patients. JJNPP. 2018; 13(1). [DOI:10.5812/jjnpp.64180]
38. Shidfar F, Ebrahimi SS, Hosseini S, Heydari I, Shidfar S and Hajhassani G. The effects of Berberis vulgaris fruit extract on serum lipoproteins, apoB, apoA-I, homocysteine, glycemic control and total antioxidant capacity in type 2 diabetic patients. IJPR. 2012; 11(2): 643-52.
39. Mahroozade S, Sohrabvand F, Bios S, Nazem I, Nazari SM, Dabaghyan FH, Taghavi Shirazi M and Iranzad Asl M. Male infertility in Iranian traditional medicine, causes, treatment and compares it with modern medicine. IJOGI. 2016; 18(183): 1-11.
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