year 24, Issue 94 (7-2025)                   J. Med. Plants 2025, 24(94): 1-18 | Back to browse issues page

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Falahatzadeh M, Sobhani Z, Zomorodian K, Hashemi S S, Zarshenas M M. Topical formulation of a skin-natural wound healing remedy based on Traditional Persian Medicine. J. Med. Plants 2025; 24 (94) :1-18
URL: http://jmp.ir/article-1-3717-en.html
Topical formulation of a skin-natural wound healing remedy based on Traditional Persian Medicine
Maryam Falahatzadeh1 , Zahra Sobhani2 , Kamiar Zomorodian3 , Seyedeh Sara Hashemi4 , Mohammad M. Zarshenas *5
1- Medicinal Plants Processing Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Quality Control, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
3- Basic Sciences in Infectious Diseases Research Center, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
4- Department of Histology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, Iran
5- Medicinal Plants Processing Research Center, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran , zarm@sums.ac.ir
Abstract:   (19 Views)
Background: Historical documents highlight various multifocal products for wound management, including the Zaroor Arbaee formulation, which comprises Commiphora myrrha, Boswellia sp., Astragalus fasciculifolius, and Dracaena sp. Objective: This study investigates a novel topical formulation for skin wound healing based on Traditional Persian Medicine, emphasizing these botanicals. Methods: A methanol extract was prepared, and an MTT assay was used to assess cytotoxicity on normal liver cells. Antimicrobial activity was evaluated using the microdilution method according to CLSI guidelines. A 5% topical cream was formulated, and total phenolic, flavonoid, and tannin contents were measured via spectrophotometry. High-performance thin-layer chromatography (HPTLC) was employed for phytochemical profiling, and essential oil extraction was performed to identify volatile constituents. Organoleptic and physicochemical tests were also conducted on the cream. Results: The MTT assay showed no cytotoxicity, and antimicrobial tests confirmed significant antifungal activity. Total phenolic, flavonoid, and tannin contents were 7.59 ± 0.31 mg, 0.54 ± 0.007 mg, and 2.07 ± 0.13 mg per 1.5 g of extract in a 30 g cream, respectively. Essential oil analysis identified furanoeudesma-1,3-diene (32.84%) and curzerene (14.94%) as major constituents. Additional assessments confirmed the cream’s stability and spreadability. Conclusion: Zaroor Arbaee appears to be a promising traditional remedy for skin wound healing.
Keywords: Wound healing, Commiphora myrrha, Boswellia, Astragalus fasciculifolius, Dracaena
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Type of Study: Research | Subject: Pharmacognosy & Pharmaceutics
Received: 2024/08/3 | Accepted: 2025/06/9 | Published: 2025/07/1
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