year 23, Issue 90 (5-2024)
J. Med. Plants 2024, 23(90): 82-93 |
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Gholizadeh Farshi Z, Naziri Z, Derakhshandeh A, Raouf Fard F. Investigation of the antibacterial effect of Ferula foetida (Bunge) Regel oleo-gum-resin extracts and essential oil on methicillin-resistant Staphylococcus aureus and its simultaneous effect with vancomycin. J. Med. Plants 2024; 23 (90) :82-93
URL: http://jmp.ir/article-1-3629-en.html
URL: http://jmp.ir/article-1-3629-en.html
1- Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran
2- Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran ,z.naziri@shirazu.ac.ir
3- Department of Horticultural Sciences, School of Agriculture, Shiraz University, Shiraz, Iran
2- Department of Pathobiology, School of Veterinary Medicine, Shiraz University, Shiraz, Iran ,
3- Department of Horticultural Sciences, School of Agriculture, Shiraz University, Shiraz, Iran
Abstract: (200 Views)
Background: Nowadays, the decreased susceptibility of Staphylococcus aureus (S. aureus) to last-resort antibiotics such as vancomycin has caused concern in both human and veterinary medicine. Therefore, the need to find alternative treatments and new antibacterial agents is felt more than ever. Objective: The antibacterial effect and simultaneous effect of Ferula foetida (Bunge) Regel (F. foetida) oleo-gum-resin (OGR) extract and vancomycin on methicillin-resistant Staphylococcus aureus (MRSA) were investigated. Methods: Aqueous, ethanolic, a mixture of aqueous and ethanolic extracts, and essential oil were prepared from F. foetida OGR collected from Beyrut village, Sabzevar, Razavi Khorasan province, Iran. The Checkerboard method was used to determine the minimum inhibitory concentrations (MICs) of vancomycin and plant extracts and essential oil, and their simultaneous effects on MRSA (ATCC 33591). The minimum bactericidal concentrations (MBCs) of these agents were also determined. Ethanolic extract and essential oil of F. foetida OGR were analyzed using gas chromatography-mass spectrometry (GC-MS). Results: The MICs of vancomycin and aqueous, ethanolic, a mixture of aqueous and ethanolic extracts, and essential oil of F. foetida OGR were 0.00195 mg/ml, 8 mg/ml, 0.25 mg/ml, 0.5 mg/ml, and 256 mg/ml, respectively. The MBCs of these agents were 0.0078 mg/ml, 64 mg/ml, 0.5 mg/ml, 2 mg/ml, and more than 512 mg/ml, respectively. The simultaneous use of the extracts and essential oil of this plant with vancomycin on MRSA showed partial synergistic to additive effects. Conclusion: The combinations of F. foetida OGR extracts or essential oil with vancomycin are expected to reduce the effective dose of vancomycin against MRSA.
Keywords: Methicillin-resistant Staphylococcus aureus, Ferula foetida, Vancomycin, Antibacterial effect, Checkerboard
Type of Study: Research |
Subject:
Pharmacognosy & Pharmaceutics
Received: 2024/03/2 | Accepted: 2024/10/1 | Published: 2024/10/26
Received: 2024/03/2 | Accepted: 2024/10/1 | Published: 2024/10/26
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