year 23, Issue 89 (3-2024)
J. Med. Plants 2024, 23(89): 1-16 |
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Mohammadi A, Zarghami Moghaddam P, Salehi Z, Shakeri F, Teimouri M, Mollazadeh S. A review of the anticancer effects of sesquiterpene nerolidol on different malignant conditions. J. Med. Plants 2024; 23 (89) :1-16
URL: http://jmp.ir/article-1-3620-en.html
URL: http://jmp.ir/article-1-3620-en.html
Ameneh Mohammadi1 
, Parastoo Zarghami Moghaddam1 , Zahra Salehi2 , Farzaneh Shakeri2 , Manouchehr Teimouri3 , Samaneh Mollazadeh *4
, Parastoo Zarghami Moghaddam1 , Zahra Salehi2 , Farzaneh Shakeri2 , Manouchehr Teimouri3 , Samaneh Mollazadeh *4
1- Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
2- Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran; Department of Medical Nanotechnology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran; Department of Medical Biotechnology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran ,SamanehMollazadeh@yahoo.com
2- Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran
3- Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran; Department of Medical Nanotechnology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran
4- Natural Products and Medicinal Plants Research Center, North Khorasan University of Medical Sciences, Bojnurd, Iran; Department of Medical Biotechnology, School of Medicine, North Khorasan University of Medical Sciences, Bojnurd, Iran ,
Abstract: (1183 Views)
Background: Nerolidol (NER) is a sesquiterpene alcohol with various biological and pharmacological activities, especially antitumor effects against different cancer models. The anticancer properties of NER are reportedly mediated by increased reactive oxygen species (ROS) production, apoptosis, and DNA damage. Nevertheless, this compound has low solubility, poor bioavailability, and fast hepatic metabolism, which could be overcome by designing proper nanoformulation scenarios. Objectives: This review focuses on the anticancer effect of NER against multiple cancers to highlight the promising features of NER as an applicable anticancer agent. Methods: A collection of papers based on the ‘cancer’ and ‘NER’ MeSH terms was chosen from NCBI/PubMed, Scopus, and Google Scholar to synthesize the current review. Results: NER was found to act as an adjuvant with contemporary chemotherapy that enhanced the efficacy of chemotherapy drugs on various cancer cells, including osteosarcoma, gastrointestinal, gynecological, breast, skin, blood, liver, and head and neck cancers. Conclusion: NER is an effective antitumor compound against different types of cancers, and its inclusion in the current chemotherapy regimen could improve cancer therapy. Because of low solubility, NER nanoformulation can improve its bioavailability and related cancer treatment.
Type of Study: Review |
Subject:
Medicinal Plants
Received: 2024/02/19 | Accepted: 2024/07/20 | Published: 2024/09/11
Received: 2024/02/19 | Accepted: 2024/07/20 | Published: 2024/09/11
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