year 22, Issue 86 (5-2023)
J. Med. Plants 2023, 22(86): 1-13 |
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Research code: art3438
Ethics code: IR.ACECR.Avhcina.REC.1396.33
Clinical trials code: IRCT20080901001157N14
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Fallah Huseini H, Mohamadzadeh K, Kianbakht S, Mohammadi S M, Ahvazi M, Hooseini M S, et al . Antihyperglycemic efficacy and safety of AKROPOL, a Persian medicine poly-herbal extract mixture, in the treatment of type 2 diabetic patients: a randomized, double-blind and placebo-controlled clinical trial. J. Med. Plants 2023; 22 (86) :1-13
URL: http://jmp.ir/article-1-3438-en.html
URL: http://jmp.ir/article-1-3438-en.html
Hasan Fallah Huseini1 
, Khalil Mohamadzadeh2 , Saeed Kianbakht1 , Sayed Mohammad Mohammadi3 , Maryam Ahvazi1 , Mahboobeh Sadat Hooseini2 , Nahid Khalili2 , Behzad Foroutan4 , Mehdi Saberi5 , Amir Baghaei6 , Reza Mohtashami * 7
, Khalil Mohamadzadeh2 , Saeed Kianbakht1 , Sayed Mohammad Mohammadi3 , Maryam Ahvazi1 , Mahboobeh Sadat Hooseini2 , Nahid Khalili2 , Behzad Foroutan4 , Mehdi Saberi5 , Amir Baghaei6 , Reza Mohtashami * 7
1- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
2- Department of Internal Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
3- Department of Internal Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran
4- Tropical and Communicable Diseases Research Center, Iranshahr University of Medical Sciences, Iranshahr, Iran; Department of Pharmacology, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran
5- Department of Pharmacology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
6- Department of Toxicology and Pharmacology, Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran
7- Medicine, Quran, and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran , reza_mohtashami1979@bmsu.ac.ir
2- Department of Internal Medicine, Baqiyatallah University of Medical Sciences, Tehran, Iran
3- Department of Internal Medicine, Shahid Sadoughi University of Medical Science, Yazd, Iran
4- Tropical and Communicable Diseases Research Center, Iranshahr University of Medical Sciences, Iranshahr, Iran; Department of Pharmacology, School of Medicine, Iranshahr University of Medical Sciences, Iranshahr, Iran
5- Department of Pharmacology, Faculty of Pharmacy, Baqiyatallah University of Medical Sciences, Tehran, Iran
6- Department of Toxicology and Pharmacology, Faculty of Pharmacy, Alborz University of Medical Sciences, Karaj, Iran
7- Medicine, Quran, and Hadith Research Center, Baqiyatallah University of Medical Sciences, Tehran, Iran , reza_mohtashami1979@bmsu.ac.ir
Abstract: (1633 Views)
Background: In Iran, a variety of medicinal plants are used, either alone or in combination, for the treatment of diabetes mellitus (DM). However, scientific and clinical studies are needed to confirm the safety and efficacy of these medicinal plants. Objective: To evaluate the safety and efficacy of AKROPOL, a poly-herbal extract mixture used in Persian medicine, in the treatment of type 2 diabetic patients. Methods: Eighty six male and female patients, aged 40-60 years, registered at the Diabetes Clinic Registry of the Baqiyatallah Hospital, in Tehran, Iran, randomly allocated to two groups of 43 each. The patients in AKROPOL group received one capsule (containing 500 mg of poly-herbal extract mixture: chicory, turmeric, nettle, fenugreek and whortleberry) and the patients in placebo group received one capsule (containing 500 mg toast powder) twice a day in addition to their routine anti-diabetic medications for 3 months. The primary outcome measures were HbA1C and FBG (fasting blood glucose) levels, while lipid levels, liver enzymes and renal function tests were secondary outcome measures. Results: Compared with the placebo group and baseline, the AKROPOL group showed significant reductions in FBG, HbA1C, total cholesterol, and LDL-C levels. No significant hepatic, renal, gastrointestinal, or other side effects were observed during the study. Conclusion: The findings suggest that AKROPOL in addition to anti-diabetic and cholesterol-lowering effects, had no adverse effects in type 2 diabetic patients.
Type of Study: Research |
Subject:
Traditional Pharmacy & Traditional Medicine
Received: 2022/09/20 | Accepted: 2023/05/15 | Published: 2023/05/31
Received: 2022/09/20 | Accepted: 2023/05/15 | Published: 2023/05/31
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