year 9, Issue 33 (3-2010)                   J. Med. Plants 2010, 9(33): 35-40 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Golabi S, Hassanpour-Ezatti M, Azhdari H, Rohampour K, Radjabian T, Ekhteraie Tousi S. Anti-nociceptive Activity of Regenerated Drosera spatulata Aqueous Extract by Rat Formalin Test. J. Med. Plants 2010; 9 (33) :35-40
URL: http://jmp.ir/article-1-309-en.html
1- Department of Physiology, Tarbiat Modarres University, Jallel Al-Ahmmad highway
2- Department of Biology, Sciences School, Shahed University , Hassanpm@yahoo.com
3- Department of Biology, Faculty of Sciences, Shahed University, Tehran-Qum highway
Abstract:   (6065 Views)
Background: The use of regenerated plants provides a new era in herbal medicine production. Objective: In this study, the analgesic effect of aqueous extracts from aerial part of regenerated Drosera spatulata (Droseraceae) was examined on Sprague Dawley rats by formalin test. Methods: The D. spatulata cultured on hormone-free solid Murashige and Skoog (MS) medium supplemented with 3% (w/v) sucrose and 0.7% (w/v) agar for 3 months. The aqueous extract prepared from aerial part of regenerated plant. Results: The extract (0.05 mg/kg, i.p.) significantly (p<0.05) and in a dose-dependent (0.05, 0.1, 0.5, 1 mg/kg, i.p.) manner reduced rat flinching responses. Sodium salicylate (300 mg/kg) was used as a positive control. Sodium salicylate (300 mg/kg, i.p.) and extract (0.05 mg/kg, i.p.) alleviated rats nociception in the second phases, while in the first phase, only the extract caused an anti-nociceptive effect (p<0.05). Conclusion: The results suggested that analgesic effect of D. Spatulata extract may be dependent on central and peripheral analgesic mechanisms. Our results indicate analgesic effect of regenerated plant extract was effective as sodium salicylate effective dose.
Full-Text [PDF 271 kb]   (1904 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2008/06/29 | Accepted: 2008/12/2 | Published: 2010/03/19

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb