year 19, Issue 76 (11-2020)                   J. Med. Plants 2020, 19(76): 89-98 | Back to browse issues page

Ethics code: 107-90/07/24.

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Esmaeili S, Omid-Malayeri S, Hajimehdipoor H, Rasekh H R, Moghimi H R, Omid-Malayeri S, et al . The role of lecithin on topical anti-inflammatory activity of turmeric (Curcuma longa L.) ointment. J. Med. Plants 2020; 19 (76) :89-98
1- 1Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran
2- Pharmaceutical Sciences Branch, Islamic Azad University, Tehran, Iran
3- 1Traditional Medicine and Materia Medica Research Center and Department of Traditional Pharmacy, School of Traditional Medicine, Shahid Beheshti University of Medical Sciences, Tehran, Iran ,
4- Department of Pharmacoeconomy & Administrative Pharmacy, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
5- Department of Pharmaceutics, School of Pharmacy, Shahid Beheshti University of Medical Sciences, Tehran, Iran
6- Student Research Committee, School of Medicine, Shahed University, Tehran, Iran
7- Department of Immunology, School of Medicine, Shahed University, Tehran, Iran
8- Department of Pathology and Anatomy, School of Medicine, Shahed University, Tehran, Iran
Abstract:   (6181 Views)
Background: Turmeric (Curcuma longa L.) is widely used in traditional medicine. In Iranian folk medicine, turmeric and egg yolk mixture is used for inflammation due to dislocations and strains. Since lecithin (one of the component of egg yolk) is an absorption enhancer, it seems this phospholipid can increase turmeric absorption and its anti-inflammatory effect. Objective: In order to find the role of lecithin in the folklore formulation, anti-inflammatory effects of ointments containing turmeric extract and lecithin have been studied. Methods: Ointment base was prepared using bees wax, vaseline, liquid paraffin and eucerin. Then, hydroalcoholic turmeric extract (2.5 % and 5 %) with lecithin (5 % and 15 %) or without lecithin were added to the ointment base. Anti-inflammatory effect of the ointments was assessed in arthritis model in rat using complete Freund’s adjuvant. Ointments were used daily on the inflamed joints for 20 days. Finally, arthritis index, TNF-α concentration and histopathological changes of joints were determined. Results: The results showed that arthritis index has decreased in all groups but it was significant in groups of turmeric 2.5 % and turmeric 5 % with lecithin 15 %. TNF-α was decreased in all samples but reduction was more significant in group turmeric 2.5 %. Histopathological changes were significantly less in turmeric groups compared to ointment base group. Conclusion: It seems that local healers use egg yolk as a binder in formulation. In other words, turmeric 2.5 % ointment is preferable compared to other formulations.
Full-Text [PDF 735 kb]   (2942 Downloads)    
Type of Study: Research | Subject: Pharmacognosy & Pharmaceutics
Received: 2020/04/19 | Accepted: 2020/11/1 | Published: 2020/12/1

1. Watson RR and Preedy VR. Botanical medicine in clinical practice. Cabi. London. 2008, pp. 672-673. [DOI:10.1079/9781845934132.0000]
2. Dei Cas M and Ghidoni R. Dietary curcumin: correlation between bioavailability and health potential. Nutrients 2019; 11: 1-14. [DOI:10.3390/nu11092147]
3. Singh A, Shekhar Ch, Varun Kumar Singh VK and Reddy KRC. Turmeric (Curcuma longa) an adaptable drug in ayurveda: a review. Indian J. Agric. Allied Sci. 2017; 3 (1): 78-84.
4. Jacob A, Wu R, Zhou M and Wang P. Mechanism of the Anti-inflammatory Effect of Curcumin: PPAR-γ Activation. PPAR Res. 2007; 2007: 1-5. [DOI:10.1155/2007/89369]
5. Boroumand N, Samarghandian S and Hashemy SI. Immunomodulatory, anti-inflammatory, and antioxidant effects of curcumin. J. Herbmed Pharmacol. 2018; 7 (4): 211-219. [DOI:10.15171/jhp.2018.33]
6. Gan Y, Zheng Sh, Baak JPA, Zhao S, Zheng Y, Luo N, Liao W and Fu Ch. Prediction of the anti-inflammatory mechanisms of curcumin by module-based protein interaction network analysis. Acta Pharm. Sinic. B 2015; 5 (6): 590-595. [DOI:10.1016/j.apsb.2015.09.005]
7. Rauta S, Bhadoriyaa SS, Uplanchiwara V, Mishrab V, Gahanea A and Kumar S. Lecithin organogel: A unique micellar system for the delivery of bioactive agents in the treatment of skin aging. Acta Pharm. Sinic. B 2012; 2 (1): 8-15. [DOI:10.1016/j.apsb.2011.12.005]
8. Editorial Board. Brithish pharmacopeia. 7th ed. The Stationary Office. London. 2013. Turmeric monograph.
9. Chang Y, Wu Y, Wang D, Wei W, Qin Q, Wie G, Zhang L, Yan Sh, Chen J, Wang Q, Wu H, Xio F, Sun W, Jin J and Wang W. Therapeutic effects of TACI-Ig on rats with adjuvant-induced arthritis via attenuating inflammatory responses. Rheumatology 2011; 50 (5): 862-870. [DOI:10.1093/rheumatology/keq404]
10. Panahi Y, Fazlolahzadeh O, Atkin SL, Majeed M, Butler AE, Johnston TP and Sahebkar A. Evidence of curcumin and curcumin analogue effects in skin diseases: A narrative review. J. Cell Physiol. 2018; 1-14. [DOI:10.1002/jcp.27096]
11. Pichot R, Watson RL and Norton IT. Phospholipids at the interface: current trends and challenges. Int. J. Mol. Sci. 2013; 14: 11767-11794. [DOI:10.3390/ijms140611767]
12. Kidd PM. Bioavailibility and activity of phytosome complexes from botanical polyphenols: the silymarin, curcumin, green tea and grape seed extracts. Altern. Med. Rev. 2009; 14: 226-246.
13. Saija A, Tomaino A, Trombetta D, Giacchi M, De Pasquale A and Bonina F. Influence of different penetration enhancers on in vitro skin permeation and in vivo photoprotective effect of flavonoids. Int. J. Pharmaceutics. 1998; 175: 85-94. [DOI:10.1016/S0378-5173(98)00259-2]
14. Kumar M, Ahuja M and Sharma SK. Hepatoprotective study of curcumin-soya lecithin complex. Sci. Pharm. 2008; 76: 761-774. [DOI:10.3797/scipharm.0808-09]
15. Leeseon K and Ji YK. Chondroprotective effect of curcumin and lecithin complex in human chondrocytes stimulated by IL-1β via an anti-inflammatory mechanism. Food Sci. Biotechnol. 2019; 28 (2): 547-553. [DOI:10.1007/s10068-018-0470-6]
16. ZAmarioli CM, Martins RM, Carvalho EC and Freitas LAP. Nanoparticles containing curcuminoids (Curcuma longa): development of topical delivery formulation. Rev. Bras. Farmacog. 2015; 25: 53-60. [DOI:10.1016/j.bjp.2014.11.010]
17. Di Pierro F, Zacconi P, Bertuccioli A, Togni S, Eggenhoffner R, Giacomelli L and Scaltrini S. A naturally-inspired, curcumin-based lecithin formulation (Meriva formulated as the finished product Algocur) alleviates the osteo-muscular pain conditions in rugby players. Eur. Rev. Med. Pharm. Sci. 2017; 21: 4935-4940.
18. Chen LC, Chen YC, Su CY, Wong WP, Sheu MT and Ho HO. Development and characterization of lecithin-based self-assembling mixed polymeric micellar (saMPMs) drug delivery systems for curcumin. Sci. Rep. 2016; 6: 37122-37132. [DOI:10.1038/srep37122]
19. Yousef SA, Mohammed YH, Namjoshi S, Grice JE, Benson HAE, Sakran W and Roberts MS. Mechanistic evaluation of enhanced curcumin delivery through human skin in vitro from optimized nanoemulsion formulations fabricated with different penetration enhancers. Pharmaceutics 2019; 11 (12): 639-658. [DOI:10.3390/pharmaceutics11120639]
20. Shahmir B. Extraction of curcumin from Curcuma amara rhizome and investigating the effect of enhancers on percutaneous absorption of curcumin and total rhizome extract. Pharm D thesis. Shadid Beheshti University of Medical Sciences, Teran, Iran, 2001.
21. Abe Y, Hashimoto S and Horie T. Curcumin inhibition of inflammatory cytokine production by human peripheral blood monocytes and alveolar macrophages. Pharmacol. Res. 1999; 39: 41-47. [DOI:10.1006/phrs.1998.0404]
22. Surh YJ, Chun KS, Cha HH, Han SS, Keum YS, Park KK and Lee SS. Molecular mechanisms underlying chemopreventive activities of anti-inflammatory phytochemicals: down-regulation of COX-2 and iNOS through suppression of NFkappa B activation. Mutat. Res. 2001; 480-481: 243-268. [DOI:10.1016/S0027-5107(01)00183-X]
23. Jobin C, Bradham CA, Russo MP, Juma B, Narula AS, Brenner DA and Sartor RB. Curcumin blocks cytokine-mediated NF-kappa B activation and proinflammatory gene expression by inhibiting inhibitory factor I-kappa B kinase activity. J. Immunol. 1999; 163: 3474-3483.
24. Huang MT, Lysz T, Ferraro T, Abidi TF, Laskin JD and Conney AH. Inhibitory effects of curcumin on in vitro lipoxygenase and cyclooxygenase activities in mouse epidermis. Cancer Res. 1991; 51: 813-819.
25. Jurenka JS. Anti-inflammatory properties of curcumin, a major constituent of Curcuma longa: a review of preclinical and clinical research. Altern. Med. Rev. 2009; 14(2): 141-153.

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2024 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb