year 9, Issue 35 (9-2010)                   J. Med. Plants 2010, 9(35): 93-98 | Back to browse issues page

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Zahedi A, Khaki A, Ahmadi-Ashtiani H, Rastegar H, Rezazadeh S. Zingiber officinale Protective Effects on Gentamicin’s Toxicity on Sperm in Rats. J. Med. Plants 2010; 9 (35) :93-98
1- Faculty of Veterinary Medicine, Islamic Azad University, Rasht Branch
2- Faculty of Veterinary Medicine, Islamic Azad University, Tabriz Branch ,
3- Biochemistry and Nutrition Department of Zanjan University of Medical Sciences, Zanjan, Iran & Department of Clinical Biochemistry, School of Medical Science, Tarbiat-e-Modarres University
4- Ministry of Health and Medical Education, Food & Drug Laboratory Research Center
5- Institute of Medicinal Plants, ACECR
Abstract:   (4982 Views)
Background: Ginger rhizome (Zingiber officinale R., family: Zingiberaceae) is used medicinally and as a culinary spice and has anti-oxidant and cell-protective effects in animals and humans body. Objective: The aim of this study was to investigate the influence of Ginger rhizome toxicity of Gentamicin on sperm parameters in male rats. Methods: Forty Wistar male rat (n=40) were allocated into four groups, control (n=10) and test groups (n=30), that subdivided into groups of 3 that received ginger rhizome powder (100 mg/kg/day), gentamicin group that received, 5 mg/kg/day and ginger group that received, 5 mg/kg/day gentamicin additionally, for 30 consequence day. Animals were kept in standard conditions. In thirty day the testes tissue of Rats in whole groups were collected. Results: Ginger administration caused a marked increase in the testosterone concentrations of the rats even in spite of receiving 5 mg/kg/day gentamicin in compared with the control and gentamicin treated groups. Conclusion: Ginger rhizome is able to overcome reproductive toxicity of gentamicin and induces spermatogenesis probably mainly through the elevation of testosterone levels.
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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2010/06/22 | Accepted: 2010/09/8 | Published: 2010/10/29

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