year 19, Issue 76 (11-2020)                   J. Med. Plants 2020, 19(76): 1-20 | Back to browse issues page


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Pournaghi N, Khalighi-Sigaroodi F, Safari E, Hajiaghaee R. A review of the genus Caesalpinia L.: emphasis on the cassane and norcassane compounds and cytotoxicity effects. J. Med. Plants 2020; 19 (76) :1-20
URL: http://jmp.ir/article-1-2602-en.html
1- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
2- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran , khalighi@imp.ac.ir
3- Immunology Department, School of Medicine, Iran University of Medical Sciences, Tehran, Iran
Abstract:   (5429 Views)
Background: Many herbal remedies have been used in medical systems for the cure of diseases. One of these important applications is usage of them as cytotoxic agents for the treatment of cancers and tumors. Various studies have been conducted on several species of Caesalpinia genus including evaluation of antimicrobial, antitumor, anti-inflammatory, antipsoriatic, antidiabetic, antioxidant, antibacterial, immunomodulatory and hypoglycemic activities. Some reports have shown that these plants contain phytochemicals like polyphenols, glycosides, terpenoids, saponins and flavonoids. Objective: The aim of this study was to find species of the Caesalpinia genus containing diterpene compounds with the structure cassane and norcassane with emphasis on cytotoxic properties. Methods: In this study, keywords including Caesalpinia genus, cytotoxic and anticancer effects, and cassane and norcassane compounds were searched in Scopus and Science Direct databases. Results: Thirteen Caesalpinia species were investigated for phytochemical composition and biological effects. Different plant parts of the species including leaves, seeds, stems, roots and legumes contained diterpenes. Among these species, the cytotoxic effects on different cancer cell lines have been evaluated and some had significant cytotoxic effects. Conclusion: Present study show that Caesalpinia genus has valuable cytotoxic activity but further studies are needed to investigate the active components and their possible development as new anticancer drugs.
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Type of Study: Review | Subject: Pharmacology & Toxicology
Received: 2019/07/22 | Accepted: 2019/11/9 | Published: 2020/12/1

References
1. Khalighi-Sigaroodi F, Hadjiakhoondi A, Ahvazi M, Taghizadeh M, Yazdani D and Khalighi-Sigaroodi Sh. Cytotoxicity screening of twenty three species of Iranian Leguminosae.3rd Congress of Medicinal Plants, Shahed University, 24 & 25 October 2007, Tehran, Iran.
2. Khalighi-Sigaroodi F, Ahvazi M, Hadjiakhoondi A, Taghizadeh M, Yazdani D, Khalighi-Sigaroodi S and Bidel S. Cytotoxicity and antioxidant activity of 23 plant species of Leguminosae family. IJPR 2012; 11(1): 295-302.
3. Khalighi-Sigaroodi F, Jeddi-Tehrani M, Ahvazi M, Shahnazi S, Bayat AA, Mohajer N and Zarei S. Cytotoxicity evaluation of two plant species from Leguminosae family on human cancer cell lines. 2nd National Congress of Medicinal Plants, National Network of Research and Technology in Medicinal Plants, 15 & 16 May 2013, Tehran, Iran.
4. Khalighi-Sigaroodi F, Jeddi-Tehrani M, Ahvazi M, Shahnazi S, Bayat AA, Mohajer N and Zarei S. Cytotoxicity evaluation of Taverniera spartea on human cancer cell lines. J. Medicinal Plants 2014; 13(50): 114-128.
5. Khalighi-Sigaroodi F, Hadjiakhoondi A, Ahvazi M, Taghizadeh M, Yazdani D and Khalighi-Sigaroodi Sh. Brine shrimp toxicity of five species of Iranian Solanaceae. 3rd Congress of Medicinal Plants, Shahed University, 24&25October 2007, Tehran, Iran.
6. Khalighi-Sigaroodi F, Ahvazi M, Yazdani D and Kashefi M. Cytotoxicity and antioxidant activity of five plant species of Solanaceae family from Iran. J. Medicinal Plants 2012; 11(43): 41-53.
7. Zanin JLB, de Carvalho BA, Martineli PS, dos Santos MH, Lago JHG, Sartorelli P, Viegas C Jr and Soares MG. The genus Caesalpinia L. (Caesalpiniaceae): phytochemical and pharmacological characteristics. Molecules 2012; 17: 7887-7902. [DOI:10.3390/molecules17077887]
8. Das B, Srinivas Y, Sudhakar C, Mahender I, Laxminarayana K, Reddy PR, Raju TV, Jakka NM and Rao JV. New diterpenoids from Caesalpinia species and their cytotoxic activity. Bioorg. Med. Chem. Lett. 2010; 20(9): 2847-2850. [DOI:10.1016/j.bmcl.2010.03.048]
9. Gledhill D. The Names of Plants. 4th ed. Cambridge University Press. UK. 2008, p: 83. [DOI:10.1017/CBO9780511550898]
10. Mozaffarian V. Plant taxonomy, first book: morphology-taxonomy. Amir-Kabir Press. Tehran. 2004, pp: 254-258.
11. The Angiosperm Phylogeny Group. An update of the Angiosperm Phylogeny Group classification for the orders and families of flowering plants: APG III. Bot. J. Linn. Soc. 2009; 161(2): 105-121.
12. Mozaffarian V. Plant taxonomy, second book: dicotyledones. Amir-Kabir Press. Tehran. 2004, pp: 238-240.
13. Ghahremaninejad F. Flora of Iran. Research Institute of Forests and Rangelands. 2004; 45, pp: 3-7.
14. Maurya R, Ravi M, Singh S and Yadav PP. A review on cassane and norcassane diterpenes and their pharmacological studies. Fitoterapia 2012; 83: 272-280. [DOI:10.1016/j.fitote.2011.12.007]
15. Dickson RA, Houghton PJ and Hylands PJ. Antibacterial and antioxidant cassane diterpenoids from Caesalpinia benthamiana. Phytochemistry 2007; 68: 1436-1441. [DOI:10.1016/j.phytochem.2007.03.008]
16. Binutu OA and Cordell GA. Gallic acid derivatives from Mezoneuron benthamianum leaves. Pharm. Biol. 2000; 38(4): 284-286.
17. Mozaffarian V. Identification of medicinal and aromatic plants of Iran. Farhang Moaser. Tehran. 2013, p: 89.
18. The Plant List. Version 1.1. Published on the Internet; http://www.theplantlist.org/ (accessed 1st January 2013).
19. Wu L, Wang X, Shan S, Luo J and Kong L. New cassane-type diterpenoids from Caesalpinia bonduc. Chem. Pharm. Bull. 2014; 62(7): 729-733. [DOI:10.1248/cpb.c14-00186]
20. Wu L, Luo J, Zhang Y, Wang X, Yang L and Kong L. Cassane-type diterpenoids from the seed kernels of Caesalpinia bonduc. Fitoterapia 2014; 93: 201-208. [DOI:10.1016/j.fitote.2014.01.011]
21. Mandal EK, Mandal S, Maity S, Behera B, Maiti TK and Islam SS. Structural studies of an immunostimulating gluco-arabinan from seeds of Caesalpinia bonduc. Carbohyd. polym. 2013; 92: 704-711. [DOI:10.1016/j.carbpol.2012.08.093]
22. Dang PH, Nguyen MTT, Nguyen HX, Vu DTT, Truong SV and Nguyen NT. Three new cassane-type furanoditerpenes from the seed of Vietnamese Caesalpinia bonducella. Phytochem. Lett. 2015; 13: 99-102. [DOI:10.1016/j.phytol.2015.05.018]
23. Yadav PP, Maurya R, Sarkar J, Arora A, Kanojiya S, Sinha S, Srivastava MN and Raghubir R. Cassane diterpenes from Caesalpinia bonduc. Phytochemistry 2009; 70(2): 256-261. [DOI:10.1016/j.phytochem.2008.12.008]
24. Ata A, Gale EM and Samarasekera R. Bioactive chemical constituents of Caesalpinia bonduc (Fabaceae). Phytochem. Lett.2009; 2(3): 106-109. [DOI:10.1016/j.phytol.2009.02.002]
25. Gupta M, Mazumder Uk, Kumar RS, Sivakumar T and Vamsi ML. Antitumor activity and antioxidant status of Caesalpinia bonducella against Ehrlich ascites carcinoma in Swiss albino mice. J Pharmacol Sci. 2004; 94(2): 177-184. [DOI:10.1254/jphs.94.177]
26. Khalighi-Sigaroodi F, Hadjiakhoondi A, Ahvazi M, Taghizadeh M, Yazdani D, Khalighi-Sigaroodi Sh. Cytotoxicity evaluation of two species from Caesalpinia genus. J. Medicinal Plants 2008; 7(25): 60-70.
27. Pournaghi N, Khalighi-Sigaroodi F, Safari E and Hajiaghaee R. Investigation of cytotoxicity effect of Caesalpinia bonduc on prostate cancer cell line. 7th National Congress of Medicinal Plants, National Network of Research and Technology in Medicinal Plants, 12 & 14 May 2018, Shiraz, Iran.
28. Muruganantham N, Basavaraj KH, Dhanabal SP, Praveen TK, Shamasundar NM and Rao KS. Screening of Caesalpinia bonduc leaves for antipsoriatic activity. J. Ethnopharmacol. 2011; 133(2): 897-901. [DOI:10.1016/j.jep.2010.09.026]
29. Datte JY, Traore A, Offoumou AM and Ziegler A. Effects of leaf extract of Caesalpinia bonduc (Caesalpiniaceae) on the contractile activity of uterine smooth muscle of pregnant rats. J. Ethnopharmacol. 1998; 60(2): 149-155. [DOI:10.1016/S0378-8741(97)00144-X]
30. Parameshwar S, Srinivasan KK and Mallikarjuna Rao C. Oral antidiabetic activities of different extracts of Caesalpinia bonducella seed kernels. Pharm. Biol. 2002; 40(8): 590-595. [DOI:10.1076/phbi.40.8.590.14656]
31. Arif T, Mandal TK, Kumar N, Bhosale JD, Hole A, Sharma GL, Padhi MM, Lavekar GS and Dabur R. In vitro and in vivo antimicrobial activities of seeds of Caesalpinia bonduc Roxb. J. Ethnopharmacol. 2009; 123(1): 177-180. [DOI:10.1016/j.jep.2009.02.040]
32. Xu J, Cao X, Liu F, Ma J, Liu X, Tong L, Su G, Ohizumi Y, Lee D, Wang L and Guo Y. Characterization of diterpenoids from Caesalpinia decapetala and their anti-TMV activities. Fitoterapia 2016; 113: 144-150. [DOI:10.1016/j.fitote.2016.07.017]
33. Ma GX, Chen P, Sun ZH, Zhu NL, Li PF, Yang JS, Chen DL and Wei H.Novel cassane diterpenes from the seeds of Caesalpinia decapetala and their antiproliferative activity. Phytochem. Lett. 2016; 16: 52-55. [DOI:10.1016/j.phytol.2016.03.002]
34. Kamikawa S, Oshimo S, Ohta E, Nehira T, Omura H and Ohta S. Cassane diterpenoids from the roots of Caesalpinia decapetala var. japonica and structure revision of caesaljapin. Phytochemistry 2016; 121: 50-57. [DOI:10.1016/j.phytochem.2015.10.001]
35. Kumar R, Patel DK, Prasad SK, Laloo D, Krishnamurthy S and Hemalatha S. Type 2 antidiabetic activity of bergenin from the roots of Caesalpinia digyna Rottler. Fitoterapia 2012; 83(2): 395-401. [DOI:10.1016/j.fitote.2011.12.008]
36. Mitsui T, Ishihara R, Hayashi K, Sunadome M, Matsuura N and Nozaki H. New cassane-type diterpenoids of Caesalpinia echinata (Leguminosae) exhibiting NF-κB inhibitory activities. Chem. Pharm. Bull. 2014; 62(3): 267-273. [DOI:10.1248/cpb.c13-00812]
37. Mitsui T, Ishihara R, Hayashi K, Matsuura N, Akashi H and Nozaki H. Cassane-type diterpenoids from Caesalpinia echinata (Leguminosae) and their NF-jB signaling inhibition activities. Phytochemistry 2015; 116: 349-358. [DOI:10.1016/j.phytochem.2015.03.012]
38. Nozaki H, Hayashi K, Kido M, Kakumoto K, Ikeda S, Matsuura N, Tani H, Takaoka D, Iinuma M and Akao Y. Pauferrol A, a novel chalcone trimmer with a cyclobutane ring from Caesalpinia ferrea mart exhibiting DNA topoisomerase II inhibition and apoptosis-inducing activity. Tetrahedron Lett. 2007; 48(47): 8290-8292. [DOI:10.1016/j.tetlet.2007.09.130]
39. Cunha AP, Ribeiro ACB, Ricardo NMPS, Oliveira AC, Davila LSP, Cardoso JHL, Rodrigues DC, Azeredo HMC, Silva LMA, Brito ES, Filho JM, Rocha TM, Leal LKAM and Ricardo NMPS. Polysaccharides from Caesalpinia ferrea seeds - Chemical characterization and anti-diabetic effects in Wistar rats. Food Hydrocolloid. 2017; 65: 68-76. [DOI:10.1016/j.foodhyd.2016.10.039]
40. Vasconcelos CF, Maranhao HM, Batista TM, Carneiro EM, Ferreira F, Costa J, Soares LA, Sa MD, Souza TP and Wanderley AG. Hypoglycemic activity and molecular mechanisms of Caesalpinia ferrea Martius bark extract on streptozotocin-induced diabetes in Wistar rats. J. Ethnopharmacol. 2011; 137(3): 1533-1541. [DOI:10.1016/j.jep.2011.08.059]
41. Lopes N, Faccin-Galhardi LC, Espada SF, Pacheco AC, Ricardo NM, Linhares RE and Nozawa C. Sulfated polysaccharide of Caesalpinia ferrea inhibits simplex virus and poliovirus. Int. J. Biol. Macromol. 2013; 60: 93-99. [DOI:10.1016/j.ijbiomac.2013.05.015]
42. Nakamuraa ES, Kurosakia F, Arisawa M, Mukainaka T, Okuda M, Tokuda H, Nishino H and Pastore F. Cancer chemo preventive effects of constituents of Caesalpinia ferrea and related compounds. Cancer Lett. 2002; 177(2): 119-124. [DOI:10.1016/S0304-3835(01)00708-X]
43. Nakamuraa ES, Kurosakia F, Arisawa M, Mukainaka T, Takayasu J, Okuda M, Tokuda H, Nishino H and Pastore F. Cancer chemo preventive effects of Brazilian folk medicine, Juca, on in vivo two-stage skin carcinogenesis. J. Ethnopharmacol. 2002; 81(1): 135-137. [DOI:10.1016/S0378-8741(02)00047-8]
44. Menezes IA, Moreira IJ, Carvalho AA, Antoniolli AR and Santos MR. Cardiovascular effects of the aqueous extract from Caesalpinia ferrea: involvement of ATP-sensitive potassium channels. Vasc. Pharmacol. 2007; 47(1): 41-47. [DOI:10.1016/j.vph.2007.03.005]
45. Osman SM, Abd El-Khalik SM, El-Haddad AE and Wink M.A new steroidal compound (β-sitosterol-3-O-butyl) isolated from Caesalpinia gilliesii flowers. IJARNP. 2015; 8(2): 14-19.
46. Bi D, Xia G, Liang X, Li Y, Zhang L and Wang L. New cassane diterpenes from the fruits of Caesalpinia mimosoides Lam. Phytochem. Lett. 2017; 21: 283-286. [DOI:10.1016/j.phytol.2017.07.016]
47. Yodsaoue O, Karalai C, Ponglimanont C, Tewtrakul S and Chantrapromma S. Potential anti-inflammatory diterpenoids from the roots of Caesalpinia mimosoides Lamk. Phytochemistry 2010; 71(14-15): 1756-1764. [DOI:10.1016/j.phytochem.2010.06.016]
48. Jiang RW, Ma SC, He ZD, Huang XS, But PPH, Wang H, Chan SP, Ooi VEC, Xu HX and Mak TCW. Molecular structures and antiviral activities of naturally occurring and modified cassane furanoditerpenoids and friedelane triterpenoids from Caesalpinia minax. Bioorgan. Med. Chem. 2002; 10(7): 2161-2170. [DOI:10.1016/S0968-0896(02)00072-X]
49. Zhao P, Chen H, Wang H, Xu J, Wang M, Wang Y, Jin DQ and Guo Y. Four new cassane diterpenes from the seeds of Caesalpinia minax. Phytochem. Lett. 2013; 6(4): 606-609. [DOI:10.1016/j.phytol.2013.07.013]
50. Dong R, Yuan J, Wu S, Huang J, Xu X, Wu Z and Gao H. Anti-inflammation furanoditerpenoids from Caesalpinia minax Hance. Phytochemistry 2015; 117: 325-331. [DOI:10.1016/j.phytochem.2015.06.025]
51. Wu J, Chen G, Xu X, Huo X, Wu S, Wu Z and Gao H. Seven new cassane furanoditerpenes from the seeds of Caesalpinia minax. Fitoterapia 2014; 92: 168-176. [DOI:10.1016/j.fitote.2013.11.002]
52. Zheng Y, Zhang SW and Xuan LJ. Trinorcassane and cassane diterpenoids from the seeds of Caesalpinia minax. Fitoterapia 2015; 102: 177-181. [DOI:10.1016/j.fitote.2015.03.006]
53. Ma G, Yuan J, Wu H, Fang K, Yang J, Ma L and Xudong X. Novel cassane diterpenes from the seeds of Caesalpinia minax. Phytochem. Lett. 2012; 5(3): 617-620. [DOI:10.1016/j.phytol.2012.06.007]
54. Wu HF, Hong JY, Sun ZH, Yuan JQ, Wei H, Zhang XP, Tian Y, Zhu YD, Yang JS, Ma GX and Xu XD. Novel dinorcassane- and cassane-type diterpenes from the seeds of Caesalpinia minax. Fitoterapia 2014; 94: 172-176. [DOI:10.1016/j.fitote.2014.01.021]
55. Li Q, He YN, Niu B, Wang XG, Niu LY and Feng W. Caesalmins N-Q, new cassane diterpenes from the seeds of Caesalpinia minax. Phytochem. Lett. 2016; 17: 23-27. [DOI:10.1016/j.phytol.2016.06.008]
56. Ma G, Sun Z, Sun Z, Yuan J, Wei H, Yang J, Wu H and Xu X. Antimalarial diterpene alkaloids from the seeds of Caesalpinia minax. Fitoterapia 2014; 95: 234-239. [DOI:10.1016/j.fitote.2014.04.001]
57. Gomez-Hurtado MA, Alvarez-Esquivel FE, Rodríguez-Garcia G, Martinez-Pacheco MM, Espinoza-Madrigal RM, Pamatz-Bolanos T, Salvador-Hernandez JL, Garcia-Gutierrez HA, Cerda-Garcia-Rojas CM, Joseph-Nathan P and del Rio RE. Cassane diterpenes from Caesalpinia platyloba. Phytochemistry 2013; 96: 397-403. [DOI:10.1016/j.phytochem.2013.09.028]
58. Thombre NA and Gide PS. Rheological characterization of galactomannans extracted from seeds of Caesalpinia pulcherrima. Carbohyd. Polym. 2013; 94(1): 547-554. [DOI:10.1016/j.carbpol.2013.01.051]
59. Yodsaoue O, Karalai C, Ponglimanont C, Tewtrakul Sand Chantrapromma S. Pulcherrins D-R, potential anti-inflammatory diterpenoids from the roots of Caesalpinia pulcherrima. Tetrahedron 2011; 67(36): 6838-6846. [DOI:10.1016/j.tet.2011.06.087]
60. Rao YK, Fang SH and Tzeng YM. Anti-inflammatory activities of flavonoids isolated from Caesalpinia pulcherrima. J. Ethnopharmacol. 2005; 100(3): 249-253. [DOI:10.1016/j.jep.2005.02.039]
61. Min BS, Cuong TD, Hung TM, Min BK, Shin BS and Woo MH. Compounds from the heartwood of Caesalpinia sappan and their anti-inflammatory activity. Bioorg. Med. Chem. Lett. 2012; 22(24): 7436-7439. [DOI:10.1016/j.bmcl.2012.10.055]
62. Xiao F, Tang CP, Ke CQ, Yao Sand Ye Y. Rearranged diterpenoids from the seeds of Caesalpinia sappan. Chinese Chem. Lett. 2016; 27(12): 1751-1754. [DOI:10.1016/j.cclet.2016.04.022]
63. Nguyen HX, Nguyen NT, Dang PH, Ho PT, Nguyen MTT, Can MV, Dibwe DF, Ueda JY and Awale S. Cassane diterpenes from the seed kernels of Caesalpinia sappan. Phytochemistry 2016; 122: 286-293. [DOI:10.1016/j.phytochem.2015.12.018]
64. Nguyen HX, Nguyen MTT, Nguyen TA, Nguyen NYT, Phan DAT, Thi PH, Nguyen THP, Dang PH, Nguyen NT, Ueda JY and Awale S. Cleistanthane diterpenes from the seed of Caesalpinia sappan and their antiausterity activity against PANC-1 human pancreatic cancer cell line. Fitoterapia 2013; 91: 148-153. [DOI:10.1016/j.fitote.2013.08.018]
65. Nguyen MTT, Awale S, Tezuka Y, Tran QL and Kadota S. Neosappanone A, a xanthine oxidase (XO) inhibitory dimeric methanodibenzoxocinone with a new carbon skeleton from Caesalpinia sappan. Tetrahedron Lett.2004; 45: 8519-8522. [DOI:10.1016/j.tetlet.2004.09.107]
66. Kitdamrongtham W, Manosroi A, Akazawa H, Gidado A, Stienrut P, Manosroi W, Lohcharoenkal W, Akihisa T and Manosroi J. Potent anti-cervical cancer activity: synergistic effects of Thai medicinal plants in recipe N040 selected from the MANOSROI III database. J. Ethnopharmacol. 2013; 149(1): 288-296. [DOI:10.1016/j.jep.2013.06.037]
67. Lee YM, Jeong GS, Lim HD, An RB, Kim YC and Kim EC. Isoliquiritigenin 2′-methyl ether induces growth inhibition and apoptosis in oral cancer cells via heme oxygenase-1. Toxicol. In Vitro 2010; 24(3): 776-782. [DOI:10.1016/j.tiv.2009.12.024]
68. Zhang JY, Wu FH, Qu Wand Liang JY. Two new cassane diterpenoids from the seeds of Caesalpinia sappan Linn. Chin. J. Nat. Medicines 2012; 10(3): 218-221. [DOI:10.3724/SP.J.1009.2012.00218]
69. Ma GX, Zhu YD, Sun ZH, Yuan JQ, Xie Y, Zhang XP, Tian Y, Yang JS, Wu HF and Xu XD. Three new cassane diterpenes from the seeds of Caesalpinia sappan. Phytochem.Lett.2014; 8: 141-144. [DOI:10.1016/j.phytol.2014.03.008]
70. Shu SH, Deng AJ, Li ZH and Qin HL. Two novel biphenyl dimmers from the heartwood of Caesalpinia sappan. Fitoterapia 2011; 82(5): 762-766. [DOI:10.1016/j.fitote.2011.03.010]
71. Zhang Q, Liu JL, Qi XM, Qi CT and Yu Q. Inhibitory activities of Lignum Sappan extractives on growth and growth-related signaling of tumor cells. Chin. J. Nat. Medicines 2014; 12(8): 607-612. [DOI:10.1016/S1875-5364(14)60092-3]
72. Yodsaoue O, Cheenpracha S, Karalai C, Ponglimanont C, Chantrapromma S, Fun HK and Kanjana-Opas A. Phanginin A-K, diterpenoids from the seeds of Caesalpinia sappan Linn. Phytochemistry 2008; 69(5): 1242-1249. [DOI:10.1016/j.phytochem.2007.11.013]
73. Wu ZF, Bao H, Zhou FY, Liu JX, Meng FC, Feng L, Lu JJ, Zhang QW, Ye Y and Lin LG. Cytotoxic cassane diterpenoids from the seeds of Caesalpinia sappan. Chinese Chem. Lett. 2017; 28(8): 1711-1715. [DOI:10.1016/j.cclet.2017.04.023]
74. Wu HF, Zhu YD, Sun ZH, Yuan JQ, Wei H, Zhang XP, Tian Y, Yang JS, Ma GX and Xu XD. Norcassane- and cassane-type furanoditerpenoids from the seeds of Caesalpinia sappan. Fitoterapia 2014; 98: 22-26. [DOI:10.1016/j.fitote.2014.07.001]
75. Xu X, Yuan J, Zhou X, Li W, Zhu N, Wu H, Li P, Sun Z, Yang J and Ma G. Cassane diterpenes with oxygen bridge from the seeds of Caesalpinia sappan. Fitoterapia 2016; 112: 205-210. [DOI:10.1016/j.fitote.2016.06.005]
76. Wang Z, Sun JB, Qu W, Guan FQ, Li LZ and Liang JY. Caesappin A and B, two novel protosappanins from Caesalpinia sappan L. Fitoterapia 2014; 92: 280-284. [DOI:10.1016/j.fitote.2013.12.004]
77. Tao LY, Li JY and Zhang JY. Brazilein, a compound isolated from Caesalpinia sappan Linn., induced growth inhibition in breast cancer cells via involvement of GSK-3β/β-Catenin/cyclin D1 pathway. Chem-Biol. Interact. 2013; 206(1): 1-5. [DOI:10.1016/j.cbi.2013.07.015]
78. Hsieh CY, Tsai PC, Chu CL, Chang FR, Chang LS, Wu YC and Lin SR. Brazilein suppresses migration and invasion of MDA-MB-231 breast cancer cells. Chem-Biol. Interact. 2013; 204(2): 105-115. [DOI:10.1016/j.cbi.2013.05.005]
79. Bae IK, Min HY, Han AR, Seo EK and Lee SK. Suppression of lipopolysaccharide-induced expression of inducible nitric oxide synthase by brazilin in RAW 264.7 macrophage cells. Eur. J. Pharmacol. 2005; 513(3): 237-242. [DOI:10.1016/j.ejphar.2005.03.011]
80. Shen J, Zhang H, Lin H, Su H, Xing D and Du L. Brazilein protects the brain against focal cerebral ischemia reperfusion injury correlating to inflammatory response suppression. Eur. J. Pharmacol. 2007; 558(1-3): 88-95.
81. Zeng KW, Yu Q, Song FJ, Liao LX, Zhao MB, Dong X, Jiang Y and Tu PF. Deoxysappanone B, a homoisoflavone from the Chinese medicinal plant Caesalpinia sappan L., protects neurons from microglia-mediated inflammatory injuries via inhibition of IκB kinas (IKK)-NF-κB and p38/ERK MAPK pathways .Eur. J. Pharmacol. 2015; 748: 18-29. [DOI:10.1016/j.ejphar.2014.12.013]
82. He D, Li Y, Tang H, Ma R, Li X and Wang L. Six new cassane diterpenes from the twigs and leaves of Tara (Caesalpinia spinosa Kuntze). Fitoterapia 2015; 105: 273-277. [DOI:10.1016/j.fitote.2015.07.018]
83. Mu W, Tang H, Li Y, He D, Ma Rand Wang L. Caesalpinone A, a new type of gorgonane sesquiterpenoid containing an unprecedented 1,15-bridge, from the pods of Caesalpinia spinosa Kuntze. Fitoterapia 2016; 112: 233-236. [DOI:10.1016/j.fitote.2016.06.012]
84. Aguilar-Galves A, Noratto G, Chambi F, Debaste F and Campos D. Potential of tara (Caesalpinia spinosa) gallotannins and hydrolysates as natural antibacterial compounds. Food Chem. 2014; 156: 301-304. [DOI:10.1016/j.foodchem.2014.01.110]

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