year 19, Issue 73 (3-2020)                   J. Med. Plants 2020, 19(73): 170-179 | Back to browse issues page

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Salehi A, Rabiei Z, Setorki M. Antidepressant effects of hydroalcoholic extract of Alpinia officinarum rhizome on chronic unpredictable stress induced depression in BALB/c mice. J. Med. Plants 2020; 19 (73) :170-179
1- Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran
2- Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran
3- Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran ,
Abstract:   (2142 Views)
Background: Alpinia officinarum is an aromatic plant that show some neuroprotective functions in animal models. Objective: This study aimed to evaluate the antidepressant effects of hydroalcoholic extract of A. officinarum rhizome using two behavioral models. Methods: Forty male BALB/c mice were randomized to four groups. All studygroups underwent three weeks of daily chronic unpredictable stress (CUS) sessions. Control group received daily intraperitoneal (i.p.) injection of normal saline 30 min before daily CUS; groups 2, 3 and 4 received i.p. injection of 50, 100, and 150 mg/kg/day of A. officinarum extract, respectively. Behavior tests were performed after 21 days of treatment. Serum and brain malondialdehyde (MDA) and total antioxidant capacity (TCA) were also measured. Results: Immobility duration in both forced swim test and tail suspension test decreased significantly in the groups treated with A. officinarum extract at doses of 50 and 100 mg/kg compared to control group (P < 0.05). Extract treatment reduced MDA and increased TCA in both brain and serum (P < 0.05). Results demonstrate that the hydroalcoholic extract of A. officinarum possesses antidepressant activity in the animal model.
Full-Text [PDF 770 kb]   (930 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2019/07/13 | Accepted: 2020/02/23 | Published: 2020/06/6

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