year 19, Issue 73 (3-2020)
J. Med. Plants 2020, 19(73): 133-142 |
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Rabiei Z, joodaki R, setorki M. Effects of ethanolic extract of Artemisa persica on scopolamine-induced cognitive impairment and anxiety in rats. J. Med. Plants 2020; 19 (73) :133-142
URL: http://jmp.ir/article-1-2523-en.html
URL: http://jmp.ir/article-1-2523-en.html
1- Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran , zahrarabiei@ymail.com
2- Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran
2- Department of Biology, Izeh Branch, Islamic Azad University, Izeh, Iran
Abstract: (2715 Views)
Background: Artemisia persica is used as an antiseptic, carminative, appetizer, antiparasitic, and antipyretic agent as well as to relieve fascial pains, and in the past, was used to relieve neuropathic pain and facilitate uterine contractions during childbirth. Objective: The aim of this study was to investigate the antioxidant potential and effects of A. persica on scopolamine-induced cognitive impairments and anxiety. Methods: In this experimental study, 50 male rats were randomly divided into 5 groups of 10 each, including control group, scopolamine (0.7 mg/kg, intraperitoneal injection) group, and three groups receiving scopolamine and ethanolic Artemisia persica extract (100, 200, and 400 mg/kg). After three weeks of treatment, behavioral tests including passive avoidance memory, plus maze test, and rotarod test were conducted. The level of malondialdehyde and the antioxidant capacity of the serum and brain in the rats were measured. Results: Treatment with A. persica extract at 100, 200, and 400 mg/kg in rats receiving scopolamine caused a significant increase in secondary latency in shuttle Box test (P < 0.01). Treatment of rats receiving scopolamine with A. persica extract at 100, 200, and 400 mg/kg significantly decreased the time elapsed in closed arms and significantly increased the time elapsed in the open arms in plus maze test (P < 0.05). Conclusion: The results of this study indicate that A. persica can act as a potent neuropharmacologic agent against cognitive impairment by modulating cholinergic activity and neuritis in the rat hippocampus.
Type of Study: Research |
Subject:
Pharmacology & Toxicology
Received: 2019/05/15 | Accepted: 2019/07/9 | Published: 2020/06/6
Received: 2019/05/15 | Accepted: 2019/07/9 | Published: 2020/06/6
References
1. Takeda S, Sato N and Morishita R. Systemic inflammation, blood-brain barrier vulnerability and cognitive/non-cognitive symptoms in Alzheimer disease: relevance to pathogenesis and therapy. Frontiers in Aging Neuroscience 2014; 6: 171. [DOI:10.3389/fnagi.2014.00171]
2. Savonenko AV, Melnikova T, Hiatt A, Li T, Worley PF, Troncoso JC and et al. Alzheimer's therapeutics: translation of preclinical science to clinical drug development. Neuropsychopharmacol. 2012; 37 (1): 261. [DOI:10.1038/npp.2011.211]
3. Aydin E, Hritcu L, Dogan G, Hayta S and Bagci E. The effects of inhaled Pimpinellaperegrina essential oil on scopolamine-induced memory impairment, anxiety, and depression in laboratory rats. Molecular Neurobiol. 2016; 53 (9): 6557-67. [DOI:10.1007/s12035-016-9693-9]
4. Rahnama S, Rabiei Z, Alibabaei Z, Mokhtari S, Rafieian-kopaei M and Deris F. Anti-amnesic activity of Citrus aurantium flowers extract against scopolamine-induced memory impairments in rats. Neurological Sciences 2015; 36 (4): 553-60. [DOI:10.1007/s10072-014-1991-2]
5. Boonruamkaew P, Chonpathompikunlert P, Vong LB, Sakaue S, Tomidokoro Y, Ishii K and et al. Chronic treatment with a smart antioxidative nanoparticle for inhibition of amyloid plaque propagation in Tg2576 mouse model of Alzheimer's disease. Scientific Reports 2017; 7 (1): 3785. [DOI:10.1038/s41598-017-03411-7]
6. Dolatabadi HRD, Reisi P, Malekabadi HRA, Alaei H andPilehvarian AA. Effects of folic acid on passive avoidance learning and memory in rat Alzheimer model by intracerebroventricular injection of Streptozotocin. Journal of Isfahan Medical School 2010; 28 (112): 647-655.
7. Caine ED, Weingartner H, Ludlow CL, Cudahy EA and Wehry S. Qualitative analysis of scopolamine-induced amnesia. Psychopharmacol. 1981; 74 (1): 74-80. [DOI:10.1007/BF00431761]
8. Ahmad A, Ramasamy K, Jaafar SM, Majeed ABA and Mani V. Total isoflavones from soybean and tempeh reversed scopolamine-induced amnesia, improved cholinergic activities and reduced neuroinflammation in brain. Food and Chemical Toxicol. 2014; 65: 120-8. [DOI:10.1016/j.fct.2013.12.025]
9. Masoudi S, Rustaiyan A and Vahedi M. Volatile oil constituents of different parts of Artemisia chamaemelifolia and the composition and antibacterial activity of the aerial parts of A. turcomanica from Iran. Natural Product Communications 2012; 7 (11): 1519-22. [DOI:10.1177/1934578X1200701127]
10. Ahmadvand H, Amiri H, Dalvand H, Bagheri S and et al. Various antioxidant properties of essential oil and hydroalcoholic extract of Artemisapersica. Birjand Univ. Med. Sci. 2014, 20 (4): 416-424.
11. Taghizadeh Rabe SZ, Mahmoudi M, Ahi A and Emami SA. Antiproliferative effects of extracts from Iranian Artemisia species on cancer cell lines. Pharmaceutical Biol. 2011; 49 (9): 962-9. [DOI:10.3109/13880209.2011.559251]
12. Ramezani M, Fazli-Bazzaz B, Saghafi-Khadem F andDabaghian A. Antimicrobial activity of four Artemisia species of Iran. Fitoterapia 2004; 75 (2): 201-3. [DOI:10.1016/j.fitote.2003.11.006]
13. Karamoddini MK, Emami SA, Ghannad MS, Sani EA and Sahebkar A. Antiviral activities of aerial subsets of Artemisia species against Herpes Simplex virus type 1 (HSV1) in vitro. Asian Biomedicine 2011; 5 (1): 63-8. [DOI:10.5372/1905-7415.0501.007]
14. Ramazani A, Sardari S, Zakeri S and Vaziri B. In vitro antiplasmodial and phytochemical study of five Artemisia species from Iran and in vivo activity of two species. Parasitology Res. 2010; 107 (3): 593-9. [DOI:10.1007/s00436-010-1900-4]
15. Lee S-J, Chung H-Y, Lee I-K, Oh S-U andYoo I-D. Phenolics with inhibitory activity on mouse brain monoamine oxidase (MAO) from whole parts of Artemisia vulgaris L (Mugwort). Food Science and Biotechnol. 2000; 9 (3): 179-82.
16. Bora KS and Sharma A. Neuroprotective effect of Artemisia absinthium L. on focal ischemia and reperfusion-induced cerebral injury. J. Ethnopharmacol. 2010; 129 (3): 403-9. [DOI:10.1016/j.jep.2010.04.030]
17. Heo H-j, Cho H-Y, Hong B, Kim H-K, Kim E-k, Kim B-G and et al. Protective effect of 4′, 5-dihydroxy-3′, 6, 7-trimethoxyflavone from Artemisia asiatica against Aβ-induced oxidative stress in PC12 cells. Amyloid. 2001; 8 (3): 194-201. [DOI:10.3109/13506120109007362]
18. Salah SM and Jäger AK. Two flavonoids from Artemisia herba-alba Asso with in vitro GABAA-benzodiazepine receptor activity. J. Ethnopharmacol. 2005; 99 (1): 145-6. [DOI:10.1016/j.jep.2005.01.031]
19. Gülçin İ. Antioxidant activity of caffeic acid (3, 4-dihydroxycinnamic acid). Toxicol. 2006; 217 (2-3): 213-20. [DOI:10.1016/j.tox.2005.09.011]
20. Kwon S-H, Lee H-K, Kim J-A, Hong S-I, Kim H-C, Jo T-H and et al. Neuroprotective effects of chlorogenic acid on scopolamine-induced amnesia via anti-acetylcholinesterase and anti-oxidative activities in mice. European J. Pharmacol. 2010; 649 (1-3): 210-7. [DOI:10.1016/j.ejphar.2010.09.001]
21. El-Sherbiny DA, Khalifa AE, Attia AS and Eldenshary EE-DS. Hypericumperforatum extract demonstrates antioxidant properties against elevated rat brain oxidative status induced by amnestic dose of scopolamine. Pharmacology Biochemistry and Behavior 2003; 76 (3-4): 525-33. [DOI:10.1016/j.pbb.2003.09.014]
22. Cohen J, Zimmerman G, Melamed‐Book N, Friedman A, Dori A and Soreq H. Transgenic inactivation of acetylcholinesterase impairs homeostasis in mouse hippocampal granule cells. Hippocampus 2008; 18 (2): 182-92. [DOI:10.1002/hipo.20381]
23. Shoaib M, Shah I, Ali N and Shah SWA. In vitro acetylcholinesterase and butyrylcholinesterase inhibitory potentials of essential oil of Artemisia macrocephala. Bangladesh J. Pharmacol. 2015; 10: 87-91. [DOI:10.3329/bjp.v10i1.21171]
24. Wake G, Pickering A, Lewis R, Wilkins R and Perry E. CNS acetylcholine receptor activity in European medicinal plants traditionally used to improve failing memory. J. Ethnopharmacol. 2000; 69 (2): 105-14. [DOI:10.1016/S0378-8741(99)00113-0]
25. Lee B, Sur B, Shim J, Hahm D-H and Lee H. Acupuncture stimulation improves scopolamine-induced cognitive impairment via activation of cholinergic system and regulation of BDNF and CREB expressions in rats. BMC Complementary and Alternative Medicine 2014; 14 (1): 338. [DOI:10.1186/1472-6882-14-338]
26. Vaynman S, Ying Z and Gomez‐Pinilla F. Hippocampal BDNF mediates the efficacy of exercise on synaptic plasticity and cognition. European J. Neuroscience 2004; 20 (10): 2580-90. [DOI:10.1111/j.1460-9568.2004.03720.x]
27. Komulainen P, Pedersen M, Hänninen T, Bruunsgaard H, Lakka TA, Kivipelto M and et al. BDNF is a novel marker of cognitive function in ageing women: The DR's EXTRA Study. Neurobiology of Learning and Memory 2008; 90 (4): 596-603. [DOI:10.1016/j.nlm.2008.07.014]
28. Li Y and Ohizumi Y. Search for constituents with neurotrophic factor-potentiating activity from the medicinal plants of Paraguay and Thailand. Yakugaku Zasshi 2004; 124 (7): 417-24. [DOI:10.1248/yakushi.124.417]
29. Rashidch A, Qureshi MZ, Raza SA, William J and Arshad M. Quantitative Determination of Antioxidant Potential of Artemisia persica Analele UniversităŃii din Bucuresti-Chimie (serie nouă). 2014; 19 (1): 23-30.
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