year 18, Issue 72 And S12 (Supplement 12 2019)                   J. Med. Plants 2019, 18(72 And S12): 166-173 | Back to browse issues page

XML Persian Abstract Print

Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Tayebi M, Sajadi M, Abedi A, Mohaghegh F. Effect of Aloe vera (L.) Burm.f. on the Prevention of Dermatitis in Women with Breast Cancer under Radiotherapy. J. Med. Plants 2019; 18 (72) :166-173
1- Department of Medical-Sugical Nursing, Research Committee, School of Nursing, Arak University of Medical Sciences, Arak, Iran
2- Department of Pediatric Nursing, School of Nursing, Arak University of Medical Sciences, Arak, Iran ,
3- Traditional and Complementary Medicine Research Center, School of Nursing, Arak University of Medical Sciences, Arak, Iran
4- School of Medicine, Arak University of Medical Sciences, Arak, Iran
Abstract:   (3645 Views)
Background: Dermatitis is one of the most common complications of radiation therapy in women with breast cancer. This problem can reduce the quality of life of these patients and may have a devastating effect on the mental state of these patients.
Objective: The aim of this study was to investigate the effect of Aloe barbadensis Miller on the prevention of dermatitis in women with breast cancer under radiotherapy.
Method: In this double-blind randomized clinical trial, 76 women who were treated with radiation therapy were selected based on inclusion criteria. They were randomly assigned to intervention and control groups. Then, intervention groups and controls used an Aloe vera gel and placebo twice a day on the on the area under radiotherapy, one week before the start of radiotherapy sessions. Each day, the skin of this area was assessed and the intervention was terminated when each of the symptoms of first grade dermatitis was observed based on the RTOG criteria. The number of sessions that took long to cause dermatitis was also recorded.
Results: The mean duration of onset of dermatitis based on the number of sessions was 6.45 in the control group and 12.26 in the intervention group. Comparing two groups, a significant difference was found in the meantime of dermatitis formation (P = 0.0001).
Conclusion: This study showed that local use of Aloe vera gel was effective in preventing and delaying the onset of radiation-induced dermatitis. Further research is recommended in this area.
Full-Text [PDF 453 kb]   (1144 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2018/08/4 | Accepted: 2018/12/22 | Published: 2020/03/7

1. Mousavi SM, Gouya MM, Ramazani R, Davanlou M, Hajsadeghi N and Seddighi Z. Cancer incidence and mortality in Iran. Annals of Oncol. 2008; 20 (3): 556-63. [DOI:10.1093/annonc/mdn642]
2. Enayatrad M and Salehiniya H. An investigation of changing patterns in breast cancer incidence trends among Iranian women. Quarterly Journal of Sabzevar University of Medical Sciences 2014; 22 (1): 27-35.
3. Mina LA, Storniolo AM, Kipfer HD, Hunter C and Ludwig KK. Breast cancer prevention and treatment: Springer International Publishing;pp.1-104. 2016. [DOI:10.1007/978-3-319-19437-0]
4. Mahmoodzadeh ardakani H and Dastanpoor E. Investigation of Aloe vera gel effects on the skin pigmentation due to the electron radiotherapy after Mastectomy in the Referred Patients of Isfahan Seyedolshohada Hospital During 1392. J. Med. Plants 2016; 4 (60): 66-75.
5. Ahmad SS, Duke S, Jena R, Williams MV and Burnet NG. Advances in radiotherapy. BMJ. 2012; 345: e7765. [DOI:10.1136/bmj.e7765]
6. Chan RJ, Webster J, Chung B, Marquart L, Ahmed M and Garantziotis S. Prevention and treatment of acute radiation-induced skin reactions: a systematic review and meta-analysis of randomized controlled trials. BMC Cancer 2014; 14 (1): 1. [DOI:10.1186/1471-2407-14-53]
7. Schnur JB, Love B, Scheckner BL, Green S, Gabriella A and Montgomery GH. A systematic review of patient-rated measures of radiodermatitis in breast cancer radiotherapy. American Journal of Clinical Oncol. 2011; 5 (34): 529-536.
8. Group EBCTC. Effects of radiotherapy and of differences in the extent of surgery for early breast cancer on local recurrence and 15-year survival: an overview of the randomised trials. The Lancet 2006; 366 (9503): 2087-106. [DOI:10.1016/S0140-6736(05)67887-7]
9. Pires AMT, Segreto RA and Segreto HRC. RTOG criteria to evaluate acute skin reaction and its risk factors in patients with breast cancer submitted to radiotherapy. Revista Latino-americana de Enfermagem 2008; 16 (5): 844-9. [DOI:10.1590/S0104-11692008000500008]
10. Bernier J, Bonner J, Vermorken J, Bensadoun R, Dummer R, Giralt J and et al. Consensus guidelines for the management of radiation dermatitis and coexisting acne-like rash in patients receiving radiotherapy plus EGFR inhibitors for the treatment of squamous cell carcinoma of the head and neck. Annals of Oncol. 2007; 19 (1): 142-9. [DOI:10.1093/annonc/mdm400]
11. Ansari M, Dehsara F, Mosalaei A, Omidvari S, Ahmadloo N and Mohammadianpanah M. Efficacy of topical alpha ointment (containing natural henna) compared to topical hydrocortisone (1%) in the healing of radiation-induced dermatitis in patients with breast cancer: a randomized controlled clinical trial. Iranian J. Medical Sciences 2013; 38 (4): 293.
12. Bodîrlău R, Spiridon I, Teacă CA, Anghel N, Ichim M, Colceru S and et al. Anti-inflammatory constituents from different plant species. Environmental Engineering and Management J. 2009; 8 (4): 785-92. [DOI:10.30638/eemj.2009.110]
13. Sadrnia M and Arjomandzadegan M. Comparative study on the effects of Aloe vera extract in clinical strains of Staphylococcus aureus, Klebsiella, Staphylococcus epidermidis and Escherichia coli compared to antibiotics of choice. Arak Medical University J. 2014; 17 (6): 39-46
14. Subramanian S, Kumar DS and Arulselvan P. Wound healing potential of Aloe vera leaf gel studied in experimental rabbits. Asian J. Biochem. 2006; 1 (2): 178. [DOI:10.3923/ajb.2006.178.185]
15. Boudreau MD and Beland FA. An evaluation of the biological and toxicological properties of Aloe barbadensis (miller), Aloe vera. Journal of Environmental Science and Health Part C. 2006; 24 (1): 103 - 54. [DOI:10.1080/10590500600614303]
16. Hajhashemi V, Ghannadi A and Heidari A. Anti-inflammatory and wound healing activities of Aloe littoralis in rats. Research in Pharmaceutical Sciences 2012; 7 (2): 73 - 8.
17. Grace O, Simmonds M, Smith G and Van Wyk A. Therapeutic uses of Aloe L. (Asphodelaceae) in southern Africa. J. Ethnopharmacol. 2008; 119 (3): 604 - 14. [DOI:10.1016/j.jep.2008.07.002]
18. Weheida SM, Riad NA and Masry SE. The Effect of Skin preparation by Using Aloe Vera Gel on Incidence of Skin Reactions among Breast Cancer Patients Undergoing Radiation Therapy. liver. J. Biology, Agriculture and Healthcare 2013; 3 (15): 130 - 145.
19. Bakhshi R, MSN. Baghaie M, MSN. Ghanbari A. PhD in nursing., Rahimi A, MD. Atrkar Roushon, Z, MS in statistics. Survey the effect of Aloevera cream on severity of radiotherapy induced ‎dermatitis in cancer patients in Razi hospital in Rasht in ‎‌2008. Holistic Nursing and Midwifery 2008; 18 (1): 1 - 8.
20. Olsen DL, Raub W, Bradley C, Johnson M, Macias JL, Love V and et al. editors. The effect of Aloe vera gel/mild soap versus mild soap alone in preventing skin reactions in patients undergoing radiation therapy. Oncology Nursing Forum. 2001; 28 (3): 543-7.

Add your comments about this article : Your username or Email:

Send email to the article author

Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2023 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb