year 18, Issue 72 And S12 (Supplement 12 2019)                   J. Med. Plants 2019, 18(72 And S12): 1-13 | Back to browse issues page

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Rahimi Shokooh A, Naghdi Badi H, Abdossi V, Mehrafarin A. Overview on the Agronomic, Phytochemical and Therapeutic traits of Bladder Cherry (Physalis alkekengi L.). J. Med. Plants 2019; 18 (72) :1-13
1- Department of Horticultural Science and Agronomy, Science and Research Branch, Islamic Azad University, Tehran, Iran
2- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
Abstract:   (5103 Views)
Bladder cherry (Physalis alkekengi L.) is a valuable medicinal plant of the Solanaceae family which has been used in the traditional medicine of Iran and the world and numerous therapeutic properties such as anti-fever and inflammatory, analgesic, anti-bacterial and virus have been reported for this plant. Bladder cherry is extensively used in Chinese medicine, and its fruit is used to treat abscess, cough and relieve fever, and sore throat. Brewed and boiled flower of this plant is also suitable for the treatment of diabetes and its root is used to urinary problems, skin inflammation, uric acid excretion, gout, arthritis, hemorrhoids, hepatitis, bronchitis, and liver enhancement. The most important phytochemical studies of bladder cherry originated in 1965. To date, about 124 components including steroids, flavonoids, phenylpropanoids, and alkaloids have been extracted from different parts of the plant. Approximately, 58 combinations of steroids have been reported with the highest amount of physalins in the different parts of the bladder cherry. Moreover, 19 flavonoid compounds of the bladder cherry have been extracted from its calix in the form of flavon and flavonol. In general, the results of this study indicate that the bladder cherry due to the effective phytochemical properties of the nutrition and treatment of some diseases can be used as an important medicinal plant in the pharmaceutical industry.
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Type of Study: Review | Subject: Medicinal Plants
Received: 2017/12/29 | Accepted: 2019/10/16 | Published: 2020/03/7

1. Daunay MC, Laterrot H and Janick J. Iconography of the Solanaceae from antiquity to the XVII Th. century: a rich source of information on genetic diversity and uses. Acta Hort. 2007; 745: 59-88. [DOI:10.17660/ActaHortic.2007.745.3]
2. Velichkevich FY and Zastawniak E. The state of investigations of the Late Pliocene fossil flora in the locality Kholmech, Byelorussia. Acta Univer. Carol. Geol. 2003; 46 (4): 113-119.
3. Rahimi-shkoh A, Mehrafarin A and Naghdi Badi H. Morphometric reaction of Physalis alkekeng to the application of a combination of bioactive stimulants, IBA and citric acid. The first scientific and research conference of biology and horticulture sciences in Iran, Tehran Scientific Society for the Development and Promotion of Basic Sciences and Techniques. 2015.
4. Yanaguchi H and Nishimoto K. The alkaloid of the root of Physalis alkekengi. Isolation of 3α-tigloyloxytropan. Chem. Pharm. Bull. 1955; 13 (2): 217-220. [DOI:10.1248/cpb.13.217]
5. Mehrafarin A, Qaderi A, Rezazadeh SH, Naghdi Badi H, Noormohammadi Gh and Zand E. Bioengineering of important secondary metabolites and metabolic pathways in fenugreek (Trigonella foenum-graecum L.). J. Med. Plant. 2010; 3 (35): 1-18.
6. Mehrafarin A, Rezazadeh SH, Naghdi Badi H, Noormohammadi GH, Zand E and Qaderi A. A review on biology, cultivation and biotechnology of fenugreek (Trigonella foenum-graecum L.) as a valuable medicinal plant and multipurpose. J. Med. Plant. 2011; 1 (37): 6-24.‎
7. Omidbaigi R. Production and processing of medicinal plants. Astan Quds Razavi Press. Iran. 2010, pp: 286-303.
8. Wang R. A new combination in Alkekengi (Solanaceae) for the Flora of China. Phytotaxa 2014; 178 (1): 59-60. [DOI:10.11646/phytotaxa.178.1.9]
9. Muniz J, Kretzschmar AA, Rufato L, Pelizza TR, Rufato ADR and Macedo TA. General aspects of Physalis cultivation. Ciencia Rural. Sant. Mar. 2014; 44 (6): 964-970. [DOI:10.1590/S0103-84782014005000006]
10. Sayadi S, Mehrabian A. Diversity and distribution patterns of Solanaceae in Iran: Implications for conservation and habitat management with emphasis on endemism and diversity in SW Asia. 2016.
11. Parchianloo S, Khieri A, Arghavani M and Amiri MS. The effects of Nnitroxin and biosoulfur biofetilizers on morphological and phytochemical traits of winter cherry (Physalis alkekengi). J. Agr. Sci. Sustai. Prod. 2018; 27 (4): 39-48.
12. Whitson M. Proposal to conserve the name Physalis (Solanaceae) with a conserved type. TAXON 2011; 60 (2): 608-609. [DOI:10.1002/tax.602047]
13. Rufato A, Rufato AR, Schelenper C, Lima CSM and Kretzschmar AA. Aspectostecnicos da cultura da Physalis. Lages: CAV/UDESC; Pelotas: UFPel, 2008, 100 p.
14. Li AL, Chen BJ, Li GH, Zhou MX, Li YR, Ren DM and Shen T. Physalis alkekengi L. var. franchetii (Mast.) Makino: an ethnomedical, phytochemical and pharmacological review. J. Ethnopharmacol. 2018; 10 (210): 260-274. [DOI:10.1016/j.jep.2017.08.022]
15. Mohammadi H, Tabrizi L and Salehi R. Effect of different ratio of vermicompost in growth media on seedling development of gooseberry (Physalis peruviana L.). Iranian Journal of Horticultural Sciences 2015; 45 (4): 383-390.
16. Abdossi V, Ghahremani A, Hadipanah A, Ardalani H and Aghaee K. Quantitative and qualitative responses in chemical composition of three ecotypes of fennel (Foeniculum vulgare Mill.) cultivated in Iran climatic conditions. J. Bio. Environ. Sci. 2015; 6 (3): 401-407.
17. Hong JM, Kwon OK, Shin IS, Song HH, Shin NR, Jeon, CM and Ahn KS. Anti-inflammatory activities of Physalis alkekengi var. franchetii extract through the inhibition of MMP-9 and AP-1 activation. Immunobiol. 2015; 220 (1): 1-9. [DOI:10.1016/j.imbio.2014.10.004]
18. Guiyang Health Bureau. Gui Yang Min Jian Yao Cao. Guizhou People's Press, Guiyang. 1959, p: 14.
19. Baytop T. Therapy with Medicinal Plants in Turkey (Past and Present). Nobel Medical Publishers. Istanbul. Beijing Public Health Bureau, 1999, 216 p.
20. Dolatkhahi M, Gorbaninahjoee M, Mehrafarin A, Amininejad Q and Dolatkhahi A. The ethnobotanical study of medicinal plants in Kazeron, Iran; Identification, distribution and application. J. Med. Plant. 2012; 42 (2): 163-178.
21. Montaserti A, Pourheydar, M, Khazaei M and Ghorbani R. Anti-fertility effects of Physalis alkekengi alcoholic extract in female rat. Int. J. Reprod. Med. 2007; 5 (1): 13-16.
22. Shah P and Singh Bora K. Phytochemical and therapeutic potential of Physalis species: a review. IOSR-JPBS. 2019; 14 (4): 34-51.
23. Han AR, Shim I and Seo EK. Chemical constituents of Physalis alkekengi var. franchetii. Chemistry of Natural Compounds 2015; 51 (6): 1160-1161. [DOI:10.1007/s10600-015-1517-z]
24. Zhao B. Zhao Bing Nan Lin Chuang Jing Yan Ji. People's Medical Publishing House, Beijing. 2006.
25. Matsuura T, Kawai M, Nakashima R and Butsugan Y. Bitter principles of Physalis alkekengi var Francheti. Structure of Physalin A. Tetrahed. Lett. 1969; 10: 1083-1086. [DOI:10.1016/S0040-4039(01)97745-7]
26. Torabzadeh P and Panahi P. Evaluation of Antifungal Activity of Physalis alkekengi L. Extracts on Microsporum canis, Candida albicans, Trichophyton mentagrophytes and Nocardia asteroids. Midd. East. J. Sci. Res., 2013; 13 (7): 926-29.
27. Sharma N, Bano A, Dhaliwal HS and Sharma V. Perspectives and possibilities of Indian species if genus Physalis (L.)- A comprehensive review. EJPMR. 2015; 2 (2): 326-353.
28. Basey K, Wooley and JG. Alkaloids of Physalis alkekengi. Phytochem. 1973; 12: 2557-2559. [DOI:10.1016/0031-9422(73)80488-1]
29. Sorour Aldin MH, Jozan J, Gounozli K and Farshpour Rezaei SM. Extraction, purification and identification of physalins of Physalis alkekengy in Azarbaijan. Journal of Agricultural Science (University of Tabriz). 2008; 18 (1): 39-48.
30. Yu Y, Sun L, Ma L, Li J, Hu L and Liu J. Investigation of the immunosuppressive activity of Physalin H on T lymphocytes. Int. Immuno. Pharmacol. 2010; 10: 290-297. [DOI:10.1016/j.intimp.2009.11.013]
31. Xu WX, Chen JC, LIU JQ, Zhou L, Wang YF and Qiu MH. Three new physalins from Physalis alkekengi var. franchetii. Nat. Prod. Bioprospect. 2013; 3: 103-106. [DOI:10.1007/s13659-013-0021-z]
32. Qiu L, Jiang ZH, Liu HX, Chen LX, Yao XS, Qiu F. A pair of 3-epimeric physalins from Physalisalkekengi L. J. Asian Nat. Prod. Res. 2008; 10: 881-885. [DOI:10.1080/10286020802144735]
33. Shu Z, Xing N, Wang Q, Li X, Xu B, Li Z and Kuang H. Antibacterial and anti-inflammatory activities of Physalis alkekengi var. franchetii and its main constituents. Evid. Based. Complement. Alternat. Med. 2016; 10: 435-443. [DOI:10.1155/2016/4359394]
34. Zhang R, Li QC, Zhang CL, Cao XJ and Li XL. Study on preparation and antibacterial activities of chemical constituents separated from Physalis alkekengi L. var. franchetii (Mast.) Makino. Journal of Anhui Traditional Chinese Medical College 2013; 5: 69-71.
35. Xin X, Liu F, Huang S, Wang Y and Yu D. In vitro anti lung cancer effect of Physalis alkekengi L. var. franchetii (Mast.). Zhongguo Lao Nian Yi Xue Za Zhi (Chinese journal of gerontology). Zhon. Lao. Nian. Yi. Xu. 2010; 30: 2486-2487.
36. Li X, Zhang C, Wu D, Tang L, Cao X, Xin Y, In vitro effects on intestinal bacterium of physalins from Physalis alkekengi var. Francheti. Fitoterapia 2012; 83 (8): 1460-1465. [DOI:10.1016/j.fitote.2012.08.011]
37. Li Z, Zhou Y, Zhang N, Tang N, and Liu B. Evaluation of the anti-inflammatory activity of luteolin in experimental animal models. Planta Med. 2007; 73 (3): 221-226. [DOI:10.1055/s-2007-967122]
38. Chen R, Liang J, Y and Liu R. Two Novel Neophysalins from Physalis alkekengi L. var. franchetii. Helv. Chim. Acta. 2007; 90 (5): 963-966. [DOI:10.1002/hlca.200790098]
39. Makino B, Kawai M, Iwata Y, Yamamura H, Butsugan Y, Ogawa K, Hayashi M. Physalins possessing an endoperoxy structure from Physalis alkekengi var. francheti. Structural revision of Physalin K. Bull. Chem. Soc. Jpn. 1995; 68 (1): 219-226. [DOI:10.1246/bcsj.68.219]
40. Han X, Shen T, Lou H. Dietary polyphenols and their biological significance. Int. J. Mol. Sci. 2007; 8: 950-988. [DOI:10.3390/i8090950]
41. Cai Q, Liu Y, Ma Z. Isolation and identification of chemical constituents from the fruit and calyx of Physalis alkekengi L. var. franchetii (Mast.) Makino. Shenyang Yao Ke Da Xue Xue Bao. 2009; 26: 807-810.
42. Jiang X. Hebei Zhong Cao Yao. Hebei Science Technology Press, Shijiazhuang. 2001.
43. Asano N, Kato A, Kizu H and Matsui K. 1ß-amino-2a, 3ß, 5ß-trihydroxycycloheptane from Physalis alkekengi var francheti. Phytochem. 1996; 42: 719-721. [DOI:10.1016/0031-9422(96)00034-9]
44. Zhang CY, Luo JG, Liu RH, Lin R, Yang MH, Kong LY. H NMR spectroscopy-guided isolation of newsucrose esters from Physalisalkekengi var. franchetii and their antibacterial activity. Fitoterapia 2016; 114: 138-143. [DOI:10.1016/j.fitote.2016.09.007]
45. Miao M, Yu S and Wei R. Effect of external application of Physalis alkekengi on eczema model. Zhon. Yao. Yao. L.i Yu. Lin. Chuan. 2014; 30: 108-111.
46. Funakoshi-Tago M, Nakamura K, Tago K, Mashino T and Kasahara T. Anti-inflammatory activity of structurally related flavonoids, apigenin, luteolin and fisetin. Int. Immunopharmacol. 2011; 11: 1150-1159. [DOI:10.1016/j.intimp.2011.03.012]
47. Ge Y, Duan Y, Fang G, Zhang Y and Wang S. Polysaccharides from fruit calyx of Physalis alkekengi var. francheti: Isolation, purification, structural features and antioxidant activities. Carbohyd. Polymer. 2009; 77 (2): 188-193. [DOI:10.1016/j.carbpol.2008.12.020]
48. Kawai M, Yamamoto T, Makino B, Yamamura H, Araki S, Butsugan Y and Saito K. The Structure of Physalin T from Physalis alkekengi var. francheti. J. Asia. Nat. Prod. Res. 2001; 3 (3): 199-205.
49. Bahmani M, Rafieian-Kopaei M, Naghdi N, Nejad ASM and Afsordeh O. Physalis alkekengi: a review of its therapeutic effects. J. Chem. Pharm. Sci. 2016; 9 (3): 1472-1485.
50. Qiu, L, Zhao F, Jiang ZH, Chen LX, Zhao Q, Liu HX and Qiu F. Steroids and flavonoids from Physalis alkekengi var. franchetii and their inhibitory effects on nitric oxide production. J. Nat. Prod. 2008; 71 (4): 642-646. [DOI:10.1021/np700713r]
51. Lou Z, Wang H, Zhu S, Ma C, Wang and Z. Antibacterial activity and mechanism of action of chlorogenic acid. J. Food Sc. 2011; 76 (6): 28-36. [DOI:10.1111/j.1750-3841.2011.02213.x]
52. Haddad MHF, Mahbodfar H, Zamani Z and Ramazani A. Antimalarial evaluation of selected medicinal plant extracts used in Iranian traditional medicine. Iran. J. Basic Med. Sci. 2017; 20 (4): 415.
53. Helvacı S, Kökdil G, Kawai M, Duran N, Duran G and Güvenç A. Antimicrobial activity of the extracts and physalin D from Physalis alkekengi and evaluation of antioxidant potential of physalin D. Pharmac. Boil. 2010; 48 (2): 142-150. [DOI:10.3109/13880200903062606]
54. Tao H and Shang Z, Shen Nong Ben Cao Jing Ji Zhu. Zhong Yi GuJi Press, Beijing. 1987.
55. Hsu CC, Wu YC, Farh L, Du YC, Tseng WK and Wu CC, Chang FR. Physalin B from Physalis angulate triggers the NOXA-related apoptosis pathway of human melanoma A375 cells. Food Chem. Toxicol. 2012; 50 (3-4): 619-624. [DOI:10.1016/j.fct.2011.12.017]
56. Li X, Jianping Z, Meng Y, Yanli L, Zhaochun L, Rongying L, Xiaoran L. Physalins and with anolides from the fruits of Physalis alkekengi L. var. franchetii (Mast.) Makino and the inhibitory activities against human tumor cells. Phytochem. Letter. 2014; 10: 95-100. [DOI:10.1016/j.phytol.2014.08.004]
57. Liu YL, Han SY, Zhao H, Liang J, LI Y. G, wang GY. Hypoglycemic activity of a saponin isolated from fruit calyx of Physalis alkekengi L. var. francheti (Mast.) Makino [J]. J. North. Norm. Uni. (Natural Science Edition) 2010; 2: 34-40.
58. Tong H, Liang Z and Wang G. Structural characterization and hypoglycemic activity of a polysaccharide isolated from the fruit of Physalis alkekengi L. Carbohydr. Polym. 2008; 71 (2): 316-323. [DOI:10.1016/j.carbpol.2007.06.001]
59. Guo Y, Li S, Li J, Ren Z, Chen F and Wang X. Anti-hyperglycemic activity of polysaccharides from calyx of Physalis alkekengi var. franchetii Makino on alloxan-induced mice. Int. J. boil. Macromol. 2017; 99: 249-257. [DOI:10.1016/j.ijbiomac.2017.02.086]
60. Wu l, Cai Y, Chang L. Study on the diuresis of alcohol extractive of calyx seu fructus Physalis. J. Mudan. Med. Uni. 2012; 33: 5-6.
61. Ivanova T, Popova V, Mazova N, Stoyanova A and Damyanova S. Extracts from physalis leaves (Physalis peruviana L.) for prospective application in medicine and cosmetics. Ukr. Food J. 2019; 8 (1): 222-228. [DOI:10.24263/2304-974X-2019-8-1-5]
62. Kadirova Z, Shokhista T, Dilbar D, Rano M and Gulchehra S. Micropropagation of the medicinal plant Physalis alkekengi. National Journal of Physiology, Pharmacy and Pharmacology 2019; 9 (8): 809-812. [DOI:10.5455/njppp.2019.9.0416329062019]

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