year 11, Issue 41 (2-2012)                   J. Med. Plants 2012, 11(41): 58-65 | Back to browse issues page

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Fallah Huseini H, Kianbakht S, Heshmat R. Cynara scolymus L. in Treatment of Hypercholesterolemic Type 2 Diabetic Patients: a Randomized Double-Blind Placebo-Controlled Clinical Trial. J. Med. Plants. 2012; 11 (41) :58-65
URL: http://jmp.ir/article-1-154-en.html
1- Department of Pharmacology and Applied Medicine, Institute of Medicinal Plants, ACECR
2- Department of Pharmacology and Applied Medicine, Institute of Medicinal Plants, ACECR , skianbakht@yahoo.com
3- Department of Biostatistics and Epidemiology, Tehran University of Medical Sciences
Abstract:   (4083 Views)
Background: Type 2 diabetes mellitus with hyperlipidemia is a common disease. Conventional anti-hyperglycemic and anti-hyperlipidemic drugs have limited efficacies and important side effects, so that alternative agents are needed. Previous studies suggest that fiber-free artichoke (Cynara scolymus L.) leaf extract may have anti-hyperglycemic and anti-hypercholesterolemic effects in hypercholesterolemic type 2 diabetic patients. Moreover, artichoke leaves are used traditionally as an anti-hyperglycemic and anti-hyperlipidemic remedy to treat diabetes mellitus and hyperlipidemia. Objective: The effects of artichoke leaf extract in treatment of hypercholesterolemic type 2 diabetic patients were studied. Methods: In this randomized double-blind placebo-controlled clinical trial with hypercholesterolemic type 2 diabetic patients aged 40 to 60 years not using other anti-hyperlipidemic agents and resistant to daily intake of two 5 mg glyburide tablets and two 500 mg metformin tablets, the efficacy and safety of taking fiber-free artichoke leaf extract (one 400 mg capsule t.i.d. for 2 months) combined with the aforementioned drugs in treatment of 36 patients were evaluated and compared with the placebo group (n = 36). Results: The extract lowered the blood levels of total cholesterol and LDL cholesterol significantly (P=0.002 and p=0.040 respectively) without any significant effects on the blood levels of fasting glucose, postprandial glucose, glycosylated hemoglobin, other lipids, SGOT, SGPT and creatinine (P>0.05) compared with placebo at the endpoint. No adverse effects were reported. Conclusion: Fiber-free artichoke extract may be a safe anti-hypercholesterolemic agent but does not improve glycemic control in hypercholesterolemic type 2 diabetic patients, suggesting the involvement of fibers in the anti-hyperglycemic effect of artichoke.
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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2011/11/14 | Accepted: 2012/02/23 | Published: 2012/03/18

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