year 15, Issue 57 (2-2016)                   J. Med. Plants 2016, 15(57): 19-24 | Back to browse issues page

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Rahmani Gohar M, Moslemi H, Kafshdouzan K, Mazaheri Nezhad Fard R. Antibacterial Activity of Origanum vulgare on Staphylococcus aureus in a Rat Model of Surgical Wound Infection. J. Med. Plants. 2016; 15 (57) :19-24
1- Graduated from Faculty of Veterinary Medicine, Garmsar Branch, Islamic Azad University, Garmsar, Iran
2- Department of Clinical Sciences, Faculty of Veterinary Medicine, University of Semnan, Semnan, Iran
3- Department of Microbiology, Faculty of Veterinary Medicine, University of Semnan, Semnan, Iran ,
4- Department of Pathobiology, School of Public Health, Tehran University of Medical Sciences, Tehran, Iran
Abstract:   (3545 Views)
Background: Wound infection is one of the frequent complications in patients with surgical operations. Staphylococcus aureus is the most common cause of surgical wound infections. Origanum vulgare, a common culinary herb, has been shown to have strong antimicrobial activity, especially against Gram-positive pathogens.
Objective: This study was designed to investigate the antibacterial effects of O. vulgare on S. aureus in surgical wounds using a rat model.
Methods: Twenty male Sprague-Dawley rats were divided randomly into two groups of treatment and control rats (1:1). A circular incision was made on the dorsal inter-scapular region of each rat. Then, rats were inoculated topically with 1 × 104 CFU of S. aureus at the site of skin wounds. O. vulgare extract was applied to wounds twice a day during the experiment. Animals of the control group were left untreated.
Results: The load of bacteria in untreated rats was 7 × 106 ± 6 CFU/wound while this was 2 × 105 ±1 CFU/wound for the treatment animals, which was significantly lower.
Conclusion: Results have showed that topical application of O. vulgare extract on the infected wounds included significant antibacterial activity against S. aureus.
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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2015/06/16 | Accepted: 2016/01/12 | Published: 2016/04/23

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