year 16, Issue 63 (8-2017)                   J. Med. Plants 2017, 16(63): 68-77 | Back to browse issues page

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Shohrati M, Davoudi M, Rezazadeh S, Najafian B. Clinical efficacy of topical Avena sativa versus Betamethasone in chronic pruritus due to sulfur mustard exposure. J. Med. Plants 2017; 16 (63) :68-77
1- Research Center of Chemical Injuries, Baqiyatallah University of Medical Sciences, Tehran, Iran ,
2- Department of Dermatology, Baqiyatallah University of Medical Sciences, Tehran, Iran
3- Medicinal Plants Research Center, Institute of Medicinal Plants, ACECR, Karaj, Iran
4- Department of Pediatrics, Faculty of Medicine, Baqiyatallah University of Medical Sciences, Tehran, IR Iran
Abstract:   (929 Views)
Background: Avena sativa, a well-known herbal medicine; has been used in various skin diseases such as eczema, burn and pruritus.
Objective: The objective of this study was to evaluate the effect of this herbal medicine for treatment of chronic pruritus in Sulfur Mustard (SM) exposed patients.
Methods: Veterans who referred to Baghiat-Allah dermatologic clinic for itching problems were examined by a dermatologist and randomly assigned in three different groups. Group A received ointment derived from Avena sativa plant, group B, placebo and group C, betamethasone 0.1% cream twice a day for 4 weeks. Twenty five patients were included in each group. A visual analogue scale were used for assessment of severity of pruritus and 2 questionnaire for quality of life and quality of sleep were filled for each patient.  
Results: Pruritus severity after the study by VAS method was significantly decreased in all the groups, but betamethasone group showed the largest decrease (-2.4, P<0.001). The average quality of life based on DLQI criteria and quality of sleep based on PSQI after the treatment showed the most significant difference in betamethasone group (3.52, P<0.001 and  0.96, P=0.001 respectively). Although Avena sativa showed significant effect on these criteria but it was only superior to placebo and not as effective as betamethasone.
  Conclusion: The result demonstrated that Avena sativa ointment reduced chronic pruritus, increased quality of life and quality of sleep in patients exposed to SM but betamethasone was superior in all aspects.
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Type of Study: Research | Subject: Pharmacognosy & Pharmaceutics
Received: 2016/04/20 | Accepted: 2017/08/12 | Published: 2017/08/21

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