year 16, Issue 61 And S10 (supplement 10 2017)                   J. Med. Plants 2017, 16(61 And S10 ): 110-122 | Back to browse issues page

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Roshanaee K, Dadkhah A, Fatemi F, Dini S. The protective effects of Iranian Golpar (Heracleum persicum) essential oil in liver damages induced by CCl4 in Wistar rats. J. Med. Plants 2017; 16 (61) :110-122
1- Department of Physiology, Faculty of Science, Qom Branch, Islamic Azad University, Qom, I.R. Iran ,
2- Department of Medicine, Faculty of Medicine, Qom Branch, Islamic Azad University, Qom, I.R. Iran
3- Nuclear Fuel Cycle Research School, Nuclear Science and Technology Research Institute, Tehran, I.R. Iran
4- Young Researchers and Elite Club, Karaj Branch, Islamic Azad University, Karaj, Iran
Abstract:   (1440 Views)

Background: Nowadays, liver disorders are one of the most serious and threatening problems of the health. Persian Golpar (Heracleum (H.) persicum) as an endemic medicinal plant with antioxidant and anti-inflammatory properties was  used (noted)  in the study for reducing the live injuries.

Objective: This experiment –for the first time- was conducted to consider the effects of the oils obtained from fruits of Persian Golpar on the liver toxicity induced by the injection of tetrachloride carbon (CCl4) in the Wistar rats.

Methods: In this study, 100 male Wistar rats were divided into 20 groups (n=5). Negative control group (NC) received DMSO and olive oil for two weeks and the positive control group (C) received DMSO as i.p injection in 14 days following CCl4 (2 ml/kg b.w) at day 15th. The standard group (BHT), The treatment groups received H. persicum essential oils at both doses 100 and 200 mg/kg b.w as i.p injection following CCl4 (2 ml/kg b.w) at day 15th. Then, the levels of the glutathione (GSH), total antioxidant capacity of plasma (FRAP), proxidasion lipids (MDA) and glutathione s-transferase (GST) and also liver enzymes for instance alanin teransferase (ALT) and aspartate teransferase (AST) were estimated at 4, 8, 16 and 24 h after CCL4 injection.

Results: The injection of the essential oils (at the both doses) obtained from Persian Golpar could surprisingly modulate the changes of the antioxidant/oxidative parameters as well as liver enzymes induced by CCL4 administration.

Conclusion: These results indicated the protective effect of Iranian Golpar essential oils on the liver. These effects are probably due to its antioxidant capacity.

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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2016/04/12 | Accepted: 2016/06/21 | Published: 2017/02/13

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