Background: The radiotherapy is a therapeutic procedure for various types of cancers that is associated with the skin complications So recently the researcher's consideration has been directed to phyto-therapy in order to prevent or decrease the skin complications.

Aim: The aim of this study was investigation of Aloevera gel effects on the skin pigmentation due to electron radiotherapy after mastectomy in referred patients at Isfahan Seyedolshohada hospital.

Methods: This research is a semi-experimental study. The 80 women with breast cancer after mastectomy and electron radiotherapy were selected using purposive voluntary and triple blind sampling and classified in two groups. Two questionnaire of personal information and skin pigmentation scale were applied. The Aloevera gel sensitivity test was fulfilled before intervention. The pigmentation was evaluated before intervention and at the end of each week till to the 6^th week.

Results: The investigations indicated that there were no increase in pigmentation at the end of the first week of therapy in the both groups. In the Aloevera group, at the 3^rd, 4^th and 5^th weeks, the highest degree of pigmentation changes was related to the grade I and 2.8% was related to the grade III of pigmentation changes but in this time, the 8.75% of control group were subjected to the grade III. At the end of the 6^th week, the 6.25% of the Aloevera group and the 52.5% of the control group had the grade III of pigmentation. The Kruskall Wallis and Mann-Whitney statistical tests indicated significant differences between the two groups regarding to the intensity of the skin pigmentation changes (p<0/001).

Conclusion: The topical use of the AleoVera gel could be effective in the skin pigmentation decrease in the patients that were subjected to radiotherapy. Literally this gel prevents the skin darkening resulted from the radiotherapy in a suitable manner.