year 25, Issue 97 (6-2026)
J. Med. Plants 2026, 25(97): 19-31 |
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Research code: 26268
Ethics code: IR.SUMS.REC.1401.431
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Zarshenas M M, Abbasi A, Parhizkar E. Preparation and evaluation of an oral dosage form effective in improving digestion based on the Traditional Persian Medicine. J. Med. Plants 2026; 25 (97) :19-31
URL: http://jmp.ir/article-1-3935-en.html
URL: http://jmp.ir/article-1-3935-en.html
1- Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
2- Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
3- Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran ,eparhizkar@sums.ac.ir
2- Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran
3- Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran ,
Abstract: (12 Views)
Background: The rising prevalence of digestive disorders is a significant issue in modern societies. Among the most important conditions in this category is dyspepsia, which is managed through various medicinal and lifestyle interventions. Objective: This study aimed to develop and conduct control tests to determine the active substance content in granules derived from a mixture of medicinal plants in a multi-ingredient formulation. Methods: Several multi-ingredient formulations effective for digestion were extracted from key texts of traditional Persian pharmaceuticals, namely Qarabadin textbooks. Results: From Qarabadin-e-Azam, an oral powder of Cloves (Safoof-e-qaranfol) formulation containing mastic, ginger, cloves, anise, and fennel was selected. The yielded essential oil of the mixture was analyzed using a gas chromatography device linked to a mass spectrometer. Granules were prepared using the wet granulation method, and their taste was enhanced by coating them with candy. Ethyl cellulose was sprayed onto the granules to create a coating. The prepared granules exhibited proper flow -properties as determined by the angle of repose test. The eugenol content, the primary compound in the essential oil, was analyzed in the optimized granules, revealing approximately 111.54 ± 9.63 μg of eugenol per gram of granules. Conclusion: The adjusted formulation could be marketed as a traditional Persian medicine product for further clinical evaluation.Background: The rising prevalence of digestive disorders is a significant issue in modern societies. Among the most important conditions in this category is dyspepsia, which is managed through various medicinal and lifestyle interventions. Objective: This study aimed to develop and conduct control tests to determine the active substance content in granules derived from a mixture of medicinal plants in a multi-ingredient formulation. Methods: Several multi-ingredient formulations effective for digestion were extracted from key texts of traditional Persian pharmaceuticals, namely Qarabadin textbooks. Results: From Qarabadin-e-Azam, an oral powder of Cloves (Safoof-e-qaranfol) formulation containing mastic, ginger, cloves, anise, and fennel was selected. The yielded essential oil of the mixture was analyzed using a gas chromatography device linked to a mass spectrometer. Granules were prepared using the wet granulation method, and their taste was enhanced by coating them with candy. Ethyl cellulose was sprayed onto the granules to create a coating. The prepared granules exhibited proper flow -properties as determined by the angle of repose test. The eugenol content, the primary compound in the essential oil, was analyzed in the optimized granules, revealing approximately 111.54 ± 9.63 μg of eugenol per gram of granules. Conclusion: The adjusted formulation could be marketed as a traditional Persian medicine product for further clinical evaluation.
Type of Study: Research |
Subject:
Pharmacognosy & Pharmaceutics
Received: 2025/06/13 | Accepted: 2026/04/27 | Published: 2026/06/6
Received: 2025/06/13 | Accepted: 2026/04/27 | Published: 2026/06/6
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