سال 25، شماره 97 - ( 3-1405 )
سال 25 شماره 97 صفحات 31-19 |
برگشت به فهرست نسخه ها
Research code: 26268
Ethics code: IR.SUMS.REC.1401.431
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Zarshenas M M, Abbasi A, Parhizkar E. Preparation and evaluation of an oral dosage form effective in improving digestion based on the Traditional Persian Medicine. J. Med. Plants 2026; 25 (97) :19-31
URL: http://jmp.ir/article-1-3935-fa.html
URL: http://jmp.ir/article-1-3935-fa.html
Preparation and evaluation of an oral dosage form effective in improving digestion based on the Traditional Persian Medicine. فصلنامه گياهان دارویی. 1405; 25 (97) :19-31
چکیده: (11 مشاهده)
Background: The rising prevalence of digestive disorders is a significant issue in modern societies. Among the most important conditions in this category is dyspepsia, which is managed through various medicinal and lifestyle interventions. Objective: This study aimed to develop and conduct control tests to determine the active substance content in granules derived from a mixture of medicinal plants in a multi-ingredient formulation. Methods: Several multi-ingredient formulations effective for digestion were extracted from key texts of traditional Persian pharmaceuticals, namely Qarabadin textbooks. Results: From Qarabadin-e-Azam, an oral powder of Cloves (Safoof-e-qaranfol) formulation containing mastic, ginger, cloves, anise, and fennel was selected. The yielded essential oil of the mixture was analyzed using a gas chromatography device linked to a mass spectrometer. Granules were prepared using the wet granulation method, and their taste was enhanced by coating them with candy. Ethyl cellulose was sprayed onto the granules to create a coating. The prepared granules exhibited proper flow -properties as determined by the angle of repose test. The eugenol content, the primary compound in the essential oil, was analyzed in the optimized granules, revealing approximately 111.54 ± 9.63 μg of eugenol per gram of granules. Conclusion: The adjusted formulation could be marketed as a traditional Persian medicine product for further clinical evaluation.Background: The rising prevalence of digestive disorders is a significant issue in modern societies. Among the most important conditions in this category is dyspepsia, which is managed through various medicinal and lifestyle interventions. Objective: This study aimed to develop and conduct control tests to determine the active substance content in granules derived from a mixture of medicinal plants in a multi-ingredient formulation. Methods: Several multi-ingredient formulations effective for digestion were extracted from key texts of traditional Persian pharmaceuticals, namely Qarabadin textbooks. Results: From Qarabadin-e-Azam, an oral powder of Cloves (Safoof-e-qaranfol) formulation containing mastic, ginger, cloves, anise, and fennel was selected. The yielded essential oil of the mixture was analyzed using a gas chromatography device linked to a mass spectrometer. Granules were prepared using the wet granulation method, and their taste was enhanced by coating them with candy. Ethyl cellulose was sprayed onto the granules to create a coating. The prepared granules exhibited proper flow -properties as determined by the angle of repose test. The eugenol content, the primary compound in the essential oil, was analyzed in the optimized granules, revealing approximately 111.54 ± 9.63 μg of eugenol per gram of granules. Conclusion: The adjusted formulation could be marketed as a traditional Persian medicine product for further clinical evaluation.
نوع مطالعه: پژوهشی |
موضوع مقاله:
فارماكوگنوزی و فارماسيوتيكس
دریافت: 1404/3/23 | پذیرش: 1405/2/7 | انتشار: 1405/3/16
دریافت: 1404/3/23 | پذیرش: 1405/2/7 | انتشار: 1405/3/16
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