en فارماكوگنوزی و فارماسيوتيكس Pharmacognosy & Pharmaceutics پژوهشی Research <div style="text-align: justify;"><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> The rising prevalence of digestive disorders is a significant issue in modern societies. Among the most important conditions in this category is dyspepsia, which is managed through various medicinal and lifestyle interventions. <b>Objective:</b> This study aimed to develop and conduct control tests to determine the active substance content in granules derived from a mixture of medicinal plants in a multi-ingredient formulation. <b>Methods:</b> Several multi-ingredient formulations effective for digestion were extracted from key texts of traditional Persian pharmaceuticals, namely Qarabadin textbooks. <b>Results:</b> From <i>Qarabadin-e-Azam</i>, an oral powder of Cloves (<i>Safoof-e-qaranfol</i>) formulation containing mastic, ginger, cloves, anise, and fennel was selected. The yielded essential oil of the mixture was analyzed using a gas chromatography device linked to a mass spectrometer. Granules were prepared using the wet granulation method, and their taste was enhanced by coating them with candy. Ethyl cellulose was sprayed onto the granules to create a coating. The prepared granules exhibited proper flow -properties as determined by the angle of repose test. The eugenol content, the primary compound in the essential oil, was analyzed in the optimized granules, revealing approximately 111.54 &plusmn; 9.63 &mu;g of eugenol per gram of granules. <b>Conclusion:</b> The adjusted formulation could be marketed as a traditional Persian medicine product for further clinical evaluation.</span></span><b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times="">Background:</span></span></b><span style="font-size:10.0pt"><span new="" roman="" style="font-family:" times=""> The rising prevalence of digestive disorders is a significant issue in modern societies. Among the most important conditions in this category is dyspepsia, which is managed through various medicinal and lifestyle interventions. <b>Objective:</b> This study aimed to develop and conduct control tests to determine the active substance content in granules derived from a mixture of medicinal plants in a multi-ingredient formulation. <b>Methods:</b> Several multi-ingredient formulations effective for digestion were extracted from key texts of traditional Persian pharmaceuticals, namely Qarabadin textbooks. <b>Results:</b> From <i>Qarabadin-e-Azam</i>, an oral powder of Cloves (<i>Safoof-e-qaranfol</i>) formulation containing mastic, ginger, cloves, anise, and fennel was selected. The yielded essential oil of the mixture was analyzed using a gas chromatography device linked to a mass spectrometer. Granules were prepared using the wet granulation method, and their taste was enhanced by coating them with candy. Ethyl cellulose was sprayed onto the granules to create a coating. The prepared granules exhibited proper flow -properties as determined by the angle of repose test. The eugenol content, the primary compound in the essential oil, was analyzed in the optimized granules, revealing approximately 111.54 &plusmn; 9.63 &mu;g of eugenol per gram of granules. <b>Conclusion:</b> The adjusted formulation could be marketed as a traditional Persian medicine product for further clinical evaluation.</span></span></div> Dyspepsia, Essential Oil, Mastic, Ginger, Cloves, Anise, Fennel 19 31 http://jmp.ir/browse.php?a_code=A-10-3577-1&slc_lang=en&sid=1 Mohammad Mehdi Zarshenas mmzarsh@sums.ac.ir 100319475328460049669 100319475328460049669 No Medicinal Plants Processing Research Center, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran Asma Abbasi asmaaa1366@gmail.com 100319475328460049670 100319475328460049670 No Department of Phytopharmaceuticals (Traditional Pharmacy), School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran; Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran Elahehnaz Parhizkar eparhizkar@sums.ac.ir 100319475328460049671 100319475328460049671 Yes Department of Pharmaceutics, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, Iran