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Showing 13 results for شیرین‌بیان

S Asgary , H Madani , Gh Naderi , Sh Toori, M Taleb –alhoseini ,
year 4, Issue 13 (2-2005)
Abstract

Bachground: One of the major role of liver is metabolism of xenobiotics and detoxification. But sometimes, during metabolism of xenobiotics produce active and more toxic agents which cause liver damege and disease. Use of nature products from vegetables in the treatment of diseases and liver diseases has a long history, especially in Eastern medicine. Materials and Methods: In this study, we have investigate the protective effects of polyphenolic extracts of Silybum marianum and Cichorium intybus. Liver damage induced with hepatotoxin, thioacethamide. Extracts was injected every day for a duration of 3 days, to rats, at a dosis of 25 mg/kg body weight together with thioacetamide at a dosis of 50 mg/kg body weight. In order to investigation the hepatoprotective effect of extracts against thioacetamide, activities of serum aminotrasferases (SGOT and SGPT), alkalin phosphatase, bilirubin, Na+ and K+ were measured. Results: Activities of serum aminotrasferases (SGOT and SGPT), alkalin phosphatase and bilirubin were decreased significantly in rats treatmented with extracts in compared to thioacetamide group. Conclusion: The results showed potent protective effects of these extracts against the thioacetamide induced hepatotoxicity that are due to antioxidant effet of polyphenolic compound.

Shr Monavari , M Shamsi Shahrabadi , P Mortazkar,
year 7, Issue 28 (11-2008)
Abstract

Backround: Recently, resistance to anti viral drugs has been reported. Hence, study of other components for obtaining new treatment approaches is necessary. Objective: The main objective of this study is to determine the inhibitory effect of Glycyrrihza Glabra on HSV replication. Methods: The first step was to evaluate the concentration of Glycyrrihza Glabra which was non toxic for Vero cells. Then, antiviral effects of Glycyrrihza Glabra in non toxic concentration zone were determined through TCID50 Method. IF method was also used in order to determine the reduction of viral proteins. Results: The results indicated that inhibitory effects of Glycyrrihza Glabra on replication of HSV are related to primary time of replication cycle. Conclusion: Glycyrrihza Glabra extract can be a suitable choice for treatment due to HSV infection.

Sh Shoeibi , H Hajimehdipoor, N Rahimifard , Sh Rezazadeh , T Hasanloo , F Bagheri, A Amini ,
year 9, Issue 36 (12-2010)
Abstract

Background: Helicobacter pylori infection is common in gastrointestinal tract and lead to gastritis, peptic ulcer and finally stomach cancer. Many synthetic drugs are used to eradicate the bacteria but there are some problems in treatment due to drug resistance and frequent relapses of infection. Herbal drugs are very important in the case. Glycyrrhiza glabra is used for treatment of H. pylori infection. This plant grows in different regions of Iran, therefore, investigation of anti H. pylori effects of the plant collected from different growing area is important. Objective: The aim of this study is determination of MIC of licorice roots collected from different regions of Iran against H. pylori in order to introduce the best growing area of the plant. Methods: Roots of the plant were collected from Kerman, Kermanshah, Sirjan, Sarhadd (Fars province), Istahban (Fars province), Ghasredasht (Fars province), Najaf Abad (Isfahan province), Ganjnameh (Hamedan province), Ekbatan (Hamedan province), Mahabad, Khorram Abad and Ardabil and extracted by using ethanol 80%. MIC of each extract was determined against three clinical isolated strains of H. pylori which obtained during endoscopy procedure. Results: The results showed that susceptibilities of three clinical isolated bacteria to the licorice extracts are different. Among the studied extracts, licorice roots collected from Ardabil showed the lowest MIC (at least: 125 ppm) and all strains were almost resistant to the extract from Mahabad. Conclusion: It is concluded that drug resistance is observed in herbals just like synthetic drugs. Moreover, in order to achieve best therapeutic results, before using an herbal preparation for treatment a disorder, growing area of a medicinal herb should be considered.

M Sofiabadi , Mh Esmaeili , H Haghdost Yazdy, H Azhdari Zarmehri ,
year 10, Issue 38 (5-2011)
Abstract

Background: Glycyrrhiza glabra contain antioxidant and phytoestrogens with cell protective properties. Objective: So its consumption during pregnancy may be effective on the mental features of who birthed. We evaluate the effect of glycyrrhiza glabra consumption during pregnancy on memory retrieval of the second generated mice. Methods: We used 15 females and 6 male mice (NMRI) with 20-30 gr weight. Pregnancy confirmed after coupling with vaginal plaque formation .Then the mice were singly caged and randomly assigned to 3 equal groups: Control, sham (solvent gavage) and treatment group (aqueous extract of glycyrrhiza root with 150 mg oral daily treatment from 3 until 19 day of gestation). Two mounts after birthing, the offspring’s were randomly assigned to 2 male and female groups and introduced to the memory retrieval test with using the shuttle box. The data were analyzed statistically by using ANOVA and Tukey test by using SPSS software. Results: The delay time for entering on the dark room were increased in male mice that exposed to extracts of glycyrrhiza during pregnancy in comparison to control group and it was significant in the period 1 and 2 weeks after training (p <0.05). The Latency for entering on the dark chamber was increased on the female animals that exposed with extract during pregnancy in comparison of the control group. This difference was significant in periods of 24 hours and 2 weeks after training (p <0.01, p <0.05). Conclusion: The prenatal consumptions of aqueous extract of the glycyrrhiza can increase memory retrieval of both sexes.

H Oloumi , N Hassibi ,
year 11, Issue 42 (5-2012)
Abstract

Background: Glycyrrhiza glabra roots and rhizomes which are extensively used in herbal medicines for them health effects containing more than 100 various useful compounds including phenolics and triterpene saponins (glycyrrizin) grow as a weedy plants in many different localities of Kerman province.

Objective: Regards to application of licorice roots in pharmaceutical industry, the mail goal was the comparison of some biochemical compounds content important in pharmacy, food industry and economics in G. glabra root gathering from seven localities of Kerman province.

Methods: In this research project, the content of total phenolic compounds, flavonoids and other UV absorbent compounds, tannins, anthocyanins and glycyrrhizin gathered from some natural localities of Kerman province including Baft, Bardsir, Rayen, Zangiabad and Koohbanan was investigated.

Results: The highest content of glycyrrhizin was found in Andohjerd. Shahrbabak locality showed the highest content of total phenolic compounds while the lowest was found in Andohjerd. Tannins content were highest in roots gathered from Baft.

Conclusion: Based on the results, in seems that the profile of secondary metabolites differs depending on climate parameters and environmental conditions. Therefore, roots gathered from Andohjerd with lowest height show higher quality of regards to glycyrrhizin production and roots form localities with more height like Rayen and Baft have more total phenolic compounds.

M Khanahmadi M, H Naghdi Badi , S Akhondzadeh , F Khalighi – Sigaroodi , A Mehrafarin , S Shahriari , R Hajiaghaee ,
year 12, Issue 46 (5-2013)
Abstract

Glycyrrhiza glabra L (Licorice) as native and pasture medicinal plant has most important export rule. Glycyrrhizic acid (GA) or Glycyrrhizin as a main active component of licorice root and rhizomes, is a triterpenoid saponin claimed to be up to 30-50 times sweeter than sucrose and to be used in pharmaceuticals, food and tobacco industry. Licorice root is a traditional medicine used mainly for the treatment of peptic ulcer, hepatitis C, and pulmonary and skin diseases, although clinical and experimental studies suggest that it has several other useful pharmacological properties such as antiinflammatory, antiviral, antimicrobial, antioxidative, anticancer activities, immunomodulatory, hepatoprotective and cardioprotective effects. A large number of components have been isolated from licorice, including triterpene saponins, flavonoids, isoflavonoids and chalcones, with glycyrrhizic acid normally being considered to be the main biologically active component. Understanding of the limitations and challenges in the medicinal plant are need for planning principles for development activities and conservation in this field.In this review summarizes the phytochemical, pharmacological and pharmacokinetics data, together with the clinical as one of the most important herbs in exports and adverse effects of licorice.

M Khanahmadi, H Naghdi Badi, S Akhondzadeh, F Khalighi–sigaroodi, A Mehrafarin, S Shahriari, R Hajiaghaee,
year 13, Issue 50 (5-2014)
Abstract

Glycyrrhiza glabra (Licorice) is a perennial shrub belongs to the Fabaceae family. It is widely used in food pharmaceutical products and tobacco industry because of its important secondary metabolites. Due to worldwide uses of licorice, it has significant role in export. One of the main bioactive compounds of the root is glycyrrhizic acid (GA) which is a saponine containing three carboxyl and five hydroxyl groups. Glycyrrhizic acid is used as an anti-inflammatory and anti-allergic remedy for the treatment of bronchial asthma, eczemas and other diseases. There are different methods for separation, purification, and analysis of glycyrrhizic acid (GA) from licorice roots. Most accepted technologies of them include using of solvents, water separation, polymeric macro porous resin and non-ionic surfactants. Also, high-performance liquid chromatography technique is the most important in analysis of GA.

A Hamta , Sma Shariatzadeh, M Soleimani Mehranjani , H Fallah Huseini, F Hosseinabadi,
year 13, Issue 50 (5-2014)
Abstract

Background: Glycyrrhiza glabra L. (G. glabra) root has been used in traditional medicine for treatment of several diseases. The main active constituent of G. glabra is glycyrrhizic acid with antioxidant property. The cytotoxic effects of several compound isolated from different plants have been attributed to their antioxidant properties. Objective: The present work was aimed to investigate the in-vitro cytotoxic screening of G. glabra root extract against 4T1 cell line derived from BALB/c mice mammary tumors. Methods: 4T1 cells were cultured in RPMI-1640 medium with 10% FBS and penicillin/streptomycin. Then cells treated with different concentration of G. glabra extract (50, 100, 200, 400, 800 µg/ml), taxol (1.25, 2.5, 5, 10, 20 nM) alone and in combination G. glabra and taxol for 24, 48, 72 hrs. Viability of the cells was measured through trypanblue and MTT staining. The cells morphology was studied using fluorescent dye. Results: G. glabra root extract and taxol showed significant cytotoxic effects on breast cancer cells. Condensation and deformation of the nuclei were also observed similarly for both treatments. Moreover in combination therapy, G. glabra extract enhances taxol induced cytotoxicity in cancerous cells. Conclusion: G. glabra root extract and taxol showed cytotoxicity effects and morphological changes in 4T1 cells. This reduction in the viability of the cells was dependent on dose and time.

M Farokhipour, Aa Bahaoddini, E Khoshnam,
year 15, Issue 60 (10-2016)
Abstract

Background: The licorice (Glycyrrhiza glabra) rhizome has been widely used in traditional medicine for treatment of gastrointestinal diseases.

Objective: In the present study, the effect of hydro-alcoholic extract of licorice rhizome on mechanical activity of isolated ileum of male rats has been studied.

Methods: Seven adult male rats were anesthetized by ethyl ether, their abdomen opened, and ileum dissected and divided into 1 cm segments. The segments were connected to a force transducer longitudinally and inserted to an organ bathe contained oxygenated Tyrode solution (37 °C, pH=7.4). Their mechanical activity of ileum was recorded by power lab AD instrument in basal condition, and after administration of L-NAME (10-4M) drug in the presence and absence of licorice rhizome extract (0.0175 mg/ml). Also the mechanical activity of control group segments were recorded at the same condition with extract solvent (ethanol %70).

Results: A significant decrease in mechanical activity of the isolated ileum occurred after administration of hydro-alcoholic extract of licorice compared to the control group, while the mechanical activity of ileum tissue not significantly changed in the coadministration of L-NAME and extract between experimental and control groups.

Conclusion: We can conclude that hydro-alcoholic extract of licorice has modifying effect on ileum motility, and this activity may be occurred independently to the nitrergic system.


Ar Zebarjadi, M Safari, K Cheghamirza,
year 16, Issue 61 (1-2017)
Abstract

Background: Licorice, Glycyrrhiza glabra (belong to Leguminosae family) is one of the most popular medicinal plants in the world and it is widely used in many fields such as medical, pharmaceutical, confectionery and health industries. Different parts of licorice (shoots, leaves and roots) were had various components such as Glycyrrhzin that was used for some proposes.

Objective: The current study was done with the aim of gene transfer via Agrobacterium rhizogenes by ex vitro method for hairy root production in licorice.

Methods: The experiment was laid out as a completely randomized design (CRD) with five treatments in three replications. At first, root of young plantlets was eliminated and excited plantlets were putted in the glass wool contain suspension of bacteria. After 10 to 14 days of inoculation with Agrobacterium rhizogenes, the roots were appeared. The percentage of root induction by four strains of Agrobacterium (ATCC 15834, GMI 9534, A4 and A13) with check (without bacteria) was investigated.

Results: The results of PCR analysis with specific primers for roots of composite plants (putative transgenic) was shown that three strains of bacteria (A4, A13 and GMI 9534) and strain ATCC 15834, were produced 100% and 66.66% transgenic roots respectively.

Conclusion: Thus, production of composite licorice plants was remarked due to it has low cost, fast and simple.


Nahid Ghayedi , Aa Bahaoddini , E Khoshnam ,
year 16, Issue 61 (1-2017)
Abstract

Background: Glycyrrhiza glabra (Licorice) has been traditionally used as a medicinal plant in Iran for treatment of diseases such as gastric ulcer and relieve intestinal spasms.

Objective: In the present study, the effect of hydro-alcoholic extract of licorice rhizome on mechanical activity of isolated colon of male rats has been studied.

Methods: In this experimental study, the colon tissue of 10 adult male rats were dissected and separated into two groups: experimental and control. Each group including ten strips of tissue. The segments were connected to a force transducer longitudinally and inserted to an organ bathe contained oxygenated Tyrode solution (37 °C, pH=7.4). Their mechanical activity were recorded by power lab AD instrument in basal condition, and after administration of acetylcholine (4×10-6M) and Atropine (10-6M) in the presence and absence of licorice rhizome extract (0.036 mg/ml). Also, the mechanical activity of control group segments were recorded at the same condition with extract solvent (ethanol %70).

Results: A significant decrease in mechanical activity was found after administration of hydro-alcoholic extract of licorice compared with the control group. Also, a significant decrease of mechanical activity was seen in the presence of extract and acetylcholine compared to the control group. While the mechanical activity of tissue didn’t significant changed in the presence of Atropine and extract between experimental and control groups.

Conclusion: We can conclude that hydro-alcoholic extract of licorice has modifying effect on colon motility, and this activity maybe occurred independent of the cholinergic system.


Shima Sheikhi, Ali Khamesipour, Tayebeh Radjabian, Zahra Mojallal Tabatabaei, Tooba Ghazanfari,
year 19, Issue 74 (6-2020)
Abstract

Background: Cutaneous leishmaniasis by different species of Leishmania. Pentavalen antimonials as a first line drug for treatment of cutaneous leishmaniasis have several limitations and side effects. Natural products are more considered due to their less toxicity and cost, more efficient, safety and readily available antileishmania agents. Objective: The aim of this study was to explore the effect of hydroalcoholic extract of Glycyrrhiza glabra (licorice) roots and its main component glycyrrhizic acid on promastigote and amastigote of L. major. Methods: Different dosages of hydroalcoholic extract of licorice root, glycyrrhizic acid and Glucantime with promastigote of L. major were incubated at 26 °C for 24 and 48 hours then the percentages of alive promastigotes were measured by MTT assay. The antiamastigote effects of these drugs was examined by microscopic counting of the number of amastigotes in macrophages 24 hours after treating the parasite infected macrophages with them. Promastigote and infected macrophages without any treatment was used as negative controls. Results: The IC50 values of hydroalcoholic extracts of licorice root, glycyrrhizic acid and Glucantime on promastigote of L. major was 1250 ± 0.018, 3000 ± 0.017 and 50 ± 0.043 μg/ml after 24 hours, and 1000 ± 0.016, 3000 ± 0.017 and 25 ± 0.009 μg/ml after 48 hours, respectively. The IC50 values of the licorice root extract, glycyrrhizic acid and Glucantime on amostigate was 500, 1000 and 25 μg/ml, respectively. Conclusion: Hydroalcoholic extract of licorice root and glycyrrhizic acid had cytotoxic effects on promastigotes and amastigotes of L. major.

Hassan Esmaeili, Mohammad Hossein Mirjalili, Farzaneh Zandi,
year 21, Issue 84 (12-2022)
Abstract

Background: Licorice (Glycyrrhiza glabra L.) is a well-known commercial medicinal plant with wide usage. Objective: During our ongoing aims for the selection and breeding programs of Iranian licorice (Glycyrrhiza glabra L.) populations, in the present study, total phenol content (TPC), total flavonoid content (TFC), and biological activities of the leaf extract of eight selected plant populations cultivated in the north of Tehran were investigated. Methods: The TPC and TFC were determined by Folin-Ciocalteu and aluminum chloride reagents, respectively. The antioxidant potential of the leaf extracts was measured through the evaluation of their power to reduce the Fe3+-TPTZ complex to Fe2+-TPTZ. The antibacterial activity was also assessed according to the broth micro-dilution method to determine minimum inhibitory concentration. Results: The results indicated that TPC varied from 6.18 ± 0.33 (mg GAE/g DW) in Bajgah population to 14.91 ± 1.17 (mg GAE/g DW) in Ilam population. The highest TFC was observed in Ilam (17.04 ± 1.25 mg rutin/g DW) and Marvest (15.06 ± 1.77 mg rutin/g DW) populations, respectively, without statistically significant differences. The maximum antioxidant activity was associated with the Ilam (532.18 ± 12.61 µmol Fe/g DW) population, confirming the antioxidant potential of phenolic and flavonoids compounds. The leaf extracts of Eghlid, Marvest, Ilam, and Bojnourd populations were exhibited outstanding antibacterial activity against S. aureus. Conclusion: The licorice leaf extracts showed more inhibitory effect against Staphylococcus aureus than Escherichia coli.


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