Showing 30 results for Silymarin
H Fallah Huseini , Ar Hemati , Sm Alavian ,
year 3, Issue 11 (9-2004)
Abstract
Silymarin is the seed extract of silybum marianum herbal medicine widely used for liver and bilary abnormality in China and several European country. It protect liver from several toxicity including acetaminophen, alcohol and amanita mashrom poisoning. Silymarin is composed of several flavonoids with antioxidative, anti-inflammatory and increasing cellular glutathion level properties. Although several experimental and clinical investigation indicating its efficacy against liver and prostate cancer, cisplatin induced kidney toxicity, and type II diabetes, but further clinical study need for its clinical use. However no adverse effect is reported by its chronic use or its administration to children, or pregnancy and lactation women.
H Fallah Huseini , Ab Zaree , A Babaei Zarch , R Heshmat ,
year 3, Issue 12 (11-2004)
Abstract
In diabetic condition the oxygen free radical and reduced glutathione level are the important risk factor for cataract formation. The preventive effect of antioxidant and increased cellular glutathione level on cataract formation reported in experimental studies. However in present study silybum marianum seed extract (silymarin) due to its antioxidative property, increased cellular glutathione level and cellular membrane stabilizing properties was tested against development of galactose-induced cataract. Thirty male rats of 45 days old were divided in three groups and placed in same environmental condition. One group kept as healthy control, feed on normal rat chew, second group received 30% galactose diet, and third group received 30% galactose diet as well as silymarin orally in the dose of 200 mg/kg daily. Cataract development was observed by ophthalmoscope and necked eye in both the groups of animal during the 40 days of the study. The glutathione and lipid peroxides were determined after 20 days in one lens of all rats. Results indicate that in control group first stage of cataract development were observed after 7 to 9 days and fourth stage after 29 to 35 days. In silymarin treated group all stages of cataract development were significantly delayed as compared to control group. The first stage of cataract development were observed after 19 to 23 days and fourth stage after 37 to 43 days in only 60% of animals. These results indicate that silymarin retarded the process of cataract development in galactose-fed rats. In conclusion the preventive effect of silymarin on galactose induced cataract formation may be due to antioxidant, anti-inflammatory, increased cellular glutathione level and membrane stabilizing properties of this herbal medicine.
H Fallah Huseini , Sm Alavian , T Toliat , Ah Jamshidi , R Heshmat , H Naghdi Badi , M Khani ,
year 4, Issue 13 (2-2005)
Abstract
Background: Cirrhosis is the irreversible sequel of various disorders that damage liver cells permanently over time. Presently, the use of herbal medicines for prevention and control of chronic liver diseases is in the focus of attention for both the physicians and the patients the reasons for such shift toward the use of herbals include the expensive cost of conventional drugs, adverse drug reactions, and their inefficacy. Objective: The present study was undertaken to evaluate the efficacy of herbal medicine Khar maryam or silymarin on liver cirrhosis in chronic hepatitis patients compare to placebo therapy. Method: 60 chronic hepatitis B cirrhotic patients were selected out of 500 patients referred to Tehran Hepatic Center. The patients were randomly divided in two groups of 30 patients. One group received silymarin 150mg/kg three times a day and the other group placebo received for twelve months. The outcome measures included child-pugh score, ascitis, serum aspartate aminotransferase (AST), alanine aminotransferase (ALT), total billirubin, albumin, prothrombin time, platelet and white blood cells counts. The indices were recorded in all patients before and after 12 months of drug or placebo treatment. Results: The results demonstrated that the patients treated with silymarin for 12 months had significantly better child-pugh score, decreased ascitis, decreased serum AST and ALT. In placebo administered patients all the clinical parameters recorded before and after 12 months were not significantly different. Conclusion: We conclude that silymarin treatment for 12 months in cirrhotic patients has hepatoprotective effect. To investigate the effects of this herbal remedy on the mortality rate of cirrhotic ratients, a similar study, over an extended period has to carried out.
Sa Ziai , H Fallah Huseini , T Rajabian , L Poorhoseini , H Naghdi Badi , S Rezazadeh ,
year 4, Issue 13 (2-2005)
Abstract
Background: The seeds’ extract of Milk thistle (Silybum marianum (L.) Gaertn.) is named silymarin. It is used widely in the treatment of cirrhosis, diabetes mellitus, and hypercholesterolemia. There are different methods for production of this compound but the best method is patented. Objective: In this study, we study the power of different solvents on silymarin production. Method: 10g of three samples (Marzanabad, Golshan and Hungarian samples cultivated in our research farm), powdered and defatted by petroleum ether, the defatted powders were extracted with one of the following solvents: Methanol, ethanol aceton, ethylacetate, and acetonitril. The silymarin content was assayed by HPLC. Results: The results showed that methanol is the best solvent in extracting silymarin and all of its components. After methanol, acetone and acetonitril had good power, in extracting silymarin and silybin. Conclusion: Methanol is the best solvent for silymarin extraction and then aceton and acetonitril could be replaced for it.
H Fallah Huseini , B Larijani, B Raajabipour, R Heshmat ,
year 4, Issue 13 (2-2005)
Abstract
Background: Silymarin is a free radical scavenger and cell membrane stabilizer, that may reduce insulin secretion without increasing blood-glucose concentration and this combination of effect could be useful in states of hyperinsulinaemic hyperglycemia, such as non-insulin-dependent diabetes. Objective: The aim of this study was to analyze the effect of silymarine on glycemic control of type II diabetes. Material and Methods: A 4-month randomized clinical trial study was conducted in two-well-matched groups of type II diabetes. One group (n=30) received 750mg silymarin into divided three doses per day plus standard therapy, while the control group (n=30) received standard therapy and placebo. At the beginning and the end of the study HbA1C, FBS, serum Insulin, SGOT and SGPT were measured. Results: The mean age of patients was 53.5 ±6.2 years and the mean duration of disease was 9.6±5.9 years. There was a significant decrease in fasting blood glucose (FBS) levels from 155± 46 mg/dl to 133±39mg/dl (p=0.001), also HbA1C levels from 7.82±2.01 to 6.78±1.05 (p=0.001). There was a significant decrease in SGOT (p=0.008) and SGPT (p=0.0001) levels, after 4-months treatment in the silymarin group. In addition, there was a non significant decrease in Blood Pressure and weight in this group. Conclusion: The results show that treatment with silymarin reduces the FBS and HbA1c. The effect of silymarine may be due to Antioxidative effects, reduction of the lipoproxidation of cell membranes and other unknown effects.
T Hasanloo , R Khavari-Negad , E Majidi , Sa Ziai , Mr Shams- Ardekani ,
year 4, Issue 13 (2-2005)
Abstract
Background: Silymarin complex consisted of five flavonolignans (silybin A & B, Isosylibin A & B, silychristin, silydianin and taxifolin) isolated from dried fruiets of Silybum marianum (L.) Gaertn. Silybin is the main component of silymarin complex. Hepatoprotective activeity of silymarin may related to its antioxidant property. Objective: This study was conducted to understand the environmental condition on silymarin methabolism. Methods: Silymarin extraction and flavolignans assay by spectrophotometery, TLC and HPLC was performed on Milk thistle seeds collected from different areas of Iran, Hungarian seeds cultivated in greenhouse and field in karaj. Results: Valasht and Borazjan had the highest levels of silymain content by spectrophotometery method. In TLC method all 5 components were identified. We analyzed the flavolignans contents by HPLC and results showed that Borazjan had the highest level of silymarin. Conclusion: To produce commercially silymarin we need to search for the best genotype.
T Radjabian , H Fallah Huseini , M Karami , B Zarpak, I Rasooli ,
year 4, Issue 13 (2-2005)
Abstract
Backgrond: Silymarin, the seed extract of Silybum marianum (L.) Gaertn., contains flavonolignan compounds with powerful anti-oxidant properties. The favourable effects of herbal medicine with ant-ioxidant properties on lipid profile have been reported in several experimental studies. Objective: The aim of this research was to investigate the effects of cultivated and endemic silymarins and levostatin with ant-ioxidant properties on serum lipoproteins levels and atherosclerosis development in hypercholesterolemic rabbits. Method: Hypercholesterolemic foods were fed to 5 groups of 8 rabbits, each for 60 days. One group negative control, second group received levostatin (10mg/kg) and other two groups received cultivated and endemic silymarins (200 mg/kg) daily one hour before feeding. The last group did not receive any drugs (positive control). The fasting blood total cholesterol, LDL and HDL-cholesterol and triglyceride levels were determind before starting the experiments and also after 30 and 60 days during the study. At the end of the study rabbits were killed and the extent of aortic atherosclerotic plaque were determined. Results: Results showed that, levostatin, cultivated and endemic silymarins caused a significant decrease in fasting serum cholesterol and LDL-cholesterol compared to control group. HDL-cholesterol increased and triglyceride level was significantly decreased in cultivated and endemic silymarins treated groups, as compared to positive control group. In addition, atherosclerotic plaque development was significantly decreased in levostatin, cultivated and endemic silymarins treated groups. Conclusion: Treatment of hypercholesterolemic rabbits with levostatin, cultivated and endemic silymarins showed favourable effects on serum lipid profile, as well as atherosclerotic plaque development.
Gh Karimi , H Fallah Huseini , M Ramezani , Z Tahoonian ,
year 4, Issue 13 (2-2005)
Abstract
Background: Cisplatin is an important anticancer drug, can be used in the treatment of several kinds of tumor. But its sever advese effect i.e. kidney toxicity limited its uses. Objective: the present study undertaken to find out the protective effect of methanolic extract of Silybum marianum seeds (MES) and standard silymarin against cisplatin-induced renal toxicity. Materials and Methods: 48 male 10-8 week old wistar rats randomly divided in to 6 group. They caged in same environmental condition. First group kept as control received salin, and second group received cisplantin (3 mg/kg) by single intraperitoneal injection. 3rd and 4th groups received silymarin and MES 2 hour before cicplatin adminstration. 5th and 6th group received silymarin and MES 2 hour after cisplatin administration. Results: Over five days, cisplatin treated rats showed kidney tubular necrosis and elevation in blood urea nitrogen (BUN) and serum creatinine (Scr). Pretreatment of animals with silymarin (50 mg/kg) and MES (600 mg/kg) 2h before cisplatin administration reduced BUN and Scr as well as prevent the kidney tubular damage significantly. Rats treated with silymarin and MES 2h after cisplatin administration had BUN lower but mild to moderate kidney tubular necrosis was observed. Conclusion: These results suggested that silymarin as wellas MES may protect kidney against cisplatin-induced renal toxicity and might serve as a novel combination agent with cisplatin to limit renal injury if clinical study proved its efficacy.
H Fallah Huseini , D Yazdani , Gh Amin , M Makkizadeh ,
year 4, Issue 13 (2-2005)
Abstract
Milk thisle (Silybum marianum (L.) Gaertn.) is endemic of several European, African and Asian country like Iran. Althuogh litrature on its uses in Iranian traditional medicine in is not published, but it used extensively in some European country. Several clinical and experimental study undertaken to investigate efficacy of milk thistle seed extract (Silymarin) in several chronic disease. Silymarin contain several compound like flavonoid with antioxidative property and scavengering free radical. Free radicals are by-product of abnormal body metabolism in several chronic diseases and are important factor for late complication and secondary disease. Here in this article the published data on silymarin its effect on oxidative stress and cancer are reviewed.
T Hasanloo , Ra Khavari Nejad , E Majidi,
year 6, Issue 22 (5-2007)
Abstract
Background: Silybum marianum (L.) Gaertn. has been used for centuries as an herbal medicine for treatment of liver disease. Fruits of S. marianum contain silymarin, which is composed of the flavonolignans, silybin, isosilybin, silydianin and silychristin. Objective: The aim of this research was to investigate the effects of environmental conditions on silymarin content and morphological characteristic of S. marianum. Method: The dried fruits of S. marianum were collected from 13 area of Iran and cultivated at greenhouse conditions. Morphological characteristic were studied and silymarin content analyzed by HPLC. Results: The results showed that silybin is the main component of silymarin and was affected by environmental conditions. Conclusion: The amount of silymarin was very different in cultivated and endemic plants in comparison with together. The silymarin content had a significant positive correlation with seed yield/plant, stem diameter and number of capsules/plant.
Ah Jamshidi , Hr Ahmadi - Ashtiani , Mm Naderi , S Bokaei , B Gholamhouseyni ,
year 6, Issue 23 (9-2007)
Abstract
Background: Regarding to the skin damages caused by the ultraviolet ray of sun and the need for protective materials against these mal effects, Silymarin was evaluated for the porpose. Objective: In this study, by histopathology studies and surveying the clinical symptoms the external use of an herbaceous (herbal) substance, Silymarin, in protecting the mal effects of ultraviolet ray has been evaluated. Methods: For the study 60 albino hamsters with same age and gender has been selected and they divided in two groups (each group 30 hamsters) randomly. The hair on the back of all animals shaved in an area about 2 square centimeters. The first group gets 9 miligram Silymarin with 20 micro liter acetone topically, and the second group gets only 20 micro liter acetone topically. Then both groups for 45 days exposed to ultra violet ray, 180milijoule/cm2 each day. Results and Conclusion: The results of clinical and histopathologic surveys show that topical usage of Silymarin has considerable protective effects against the mal effects of ultra violet ray on skin and this can be a promise for using this herbaceous substance as a topical sun protects substance.
Gh Karimi , M Saradeghi Keisari ,
year 6, Issue 24 (12-2007)
Abstract
Background: Depression is one of the most psychiatric disorders that there are many treatments for it. Milk thistle is a plant which has many pharmacologic effects such as antioxidant, anti-inflammatory and anticancer. It is reported that silymarin (main component of milk thistle) increase the concentration of some neurotransmitter in brain. Objective: Evaluation of the antidepressant effect of aqueous and ethanolic extracts of milk thistle. Methods: We investigated the antidepressant effect of aqueous (0.72, 1.26, 1.80 g/kg) and ethanolic (0.24, 0.42, 0.6 g/kg) extracts using modified forced swimming test in mice. Results: The ethanolic extract did not have any effect on the duration of immobility of mice. However, the aqueous extract significantly reduced the duration of immobility versus the control group. Conclusion: Aqueous extract of milk thistle showed antidepressant effect in animal model.
Ah Jamshidi , Hr Ahmadi-Ashtiani , B Gholamhouseyni , S Bokaei ,
year 6, Issue 24 (12-2007)
Abstract
Background: In poultry industry the most common and important mycotoxin is aflatoxin, and decreasing its economical and sanitary damages by using effective and inexpensive substances is the target of most of the researchers. Objective: Since the pathologic effects of aflatoxin toxicity are more important in liver, kidney and muscles, and due to the mechanism of formation of the damages and also taking in to account the other studies on silymarin effects (extract of Silybum marianum) in preventing various liver and kidney diseases, the silymarin effects reviewed on preventing the losses caused by aflatoxin due to the poultry breeding farms conditions in Iran. Methods: In this study 56 one-day chicken, divided in to 4 groups, each group contains 14 chickens. First group were feed with normal allotment, second group with normal allotment with added 1 mg/Kg aflatoxin, third group with normal allotment with 800 mg silymarin per kg body weight and with added 1 mg/Kg aflatoxin, and after 42 days biochemical, autopsy and histopathology surveys have been done on the samples. Results and Conclusion: According to the reviewed data and comparing the results of studied groups, silymarin can be recommended for decreasing the damages caused by aflatoxin during the period of breeding broiler chickens.
M Ramezani , M Azarabadi , H Fallah Huseini, H Abdi , G Baher , M Huseini,
year 7, Issue 26 (5-2008)
Abstract
Background: Diabetes mellitus type II is a chronic disease that is defined as insulin resistance situation and results in hyperglycemia and even some metabolic complications. Most of the uncontrolled type II diabetic patients preferred to continue oral therapy or alternative therapy such as herbal medicine instead of insulin therapy. Objective: We conducted this study to assess the effects of Silybum marrianum L. seed extract (silymarin) an herbal medicine on glycemic control in type II diabetes mellitus in patients who are intended to be under insulin therapy. Method: A 2-month randomized clinical trial study was conducted in two-well-matched groups of type II diabetes patients candidate for insulin therapy. One group (n=30) received 200 mg silymarin tablet three times per day plus standard therapy, while the control group (n=30) received placebo plus standard therapy. The patients were visited monthly and glycosylated hemoglobin (HbA1C), fasting blood glucose (FBS), blood sugar 2 hour post prandial (BS 2hpp), total cholesterol, LDL and HDL, triglyceride, creatinine, SGOT and SGPT levels were determined at the beginning and the end of the study after two months. Results: There was significant decrease in HbA1C levels from 9.81 to 8.25 at the end of the study in silymarin treated group but it was increased from 9.83 to 10.21 in placebo treated group. In silymarin treated group the fasting blood glucose 196 mg/dl blood sugar 2 hour post prandial 268 mg/dl, total cholesterol 211mg/dl, and LDL cholesterol129 mg/dl was decreased significantly to 160 mg/dl, 218 mg/dl, 193 mg/dl and 107mg/dl respectively. In placebo treated groups there was no significant change in any blood parameters after 2-months as compare to beginning of the study. Statistical analysis indicate that the decrease in HbA1C, fasting blood glucose and blood sugar 2 hour post prandial levels after two months was significantly decrease in silymarin treated group as compare to placebo treated group. Conclusion: Treatment of silymarin 600 mg in 3 divided doses showed positive glycemic control as well as hypolipidemic effect in type II diabetic patients need to be under insulin therapy.
H Fallah Huseini , A Zaree Mahmodabady , R Heshmat , M Raza ,
year 8, Issue 29 (2-2009)
Abstract
Background: Increased oxygen free radical and reduced glutathione level in the eye lens are important risk factor for cataract formation. The antioxidative property and increasing cellular and extra cellular glutathione level have been reported by several herbal medicines including silymarin.
Objective: In present interventional study Silybum marianum L. seed extract (silymarin) was tested against galactose-induced cataract development in rats.
Methods: Thirty male 45 days old wistar rats (150 – 200 g), were divided in three groups of 10 rats each. Cataract was induced in two groups of rats following feeding them with 30% galactose diet for 40 days. One group kept as control and silymarin in the dose of 200 mg/kg/d was administered orally (mixed with galactose diet) to other group for 40 days. Cataract development in the rats lens was observed daily by ophthalmoscope and naked eye during the study. The glutathione (GSH) and lipid peroxides (LPO) levels were determined after 20 days in all rats left eye lens.
Results: The results indicated that, in silymarin treated group all stage of cataract development were significantly delayed as compared to control group. In rats treated with silymarin the lens GSH level was increased significantly (p<0.01) and LPO levels was decreased significantly as compared to control group (p<0.05).
Conclusion: Administration of silymarin to galactose fed rats showed beneficial effect on prevention of cataract development as well as antioxidative defence system such as increase in lens GSH and decrease LPO levels.
S Rahimi Ashtiani , T Hasanloo , R Bihamta Mohammad,
year 8, Issue 32 (12-2009)
Abstract
Background: Silybum marianum (L.) Gaertn is a kind of medicinal plants. Silymarin is a derivate substance from the fruits of Milk Thistle plant which is consists of a large number of flavonolignans. Cell cultures derived from this species could be an alternative for production of flavonolignans. Elicitors cause enhancement in metabolite production by effecting on key enzymes in secondary metabolites pathways. In this study various level of Yeast extract in 5 different exposure time have been used as an biotic elicitor in order to evaluation the effect of Yeast extract on silymarin production and cell growth and nomination the best time and best consistence of the elicitor. Objective: In this study various level of Yeast extract in 5 different exposure time have been used as an biotic elicitor in order to evaluation the effect of Yeast extract on silymarin production and cell growth and nomination the best time and best consistence of the elicitor. Methods: In this work after preparation cell suspension culture of S. marianum, the effects of various level of Yeast extract (1, 2. 4, 6 and 8 mg/50 ml culture) in 6 different exposure time (12, 24, 48, 72, 144 and 216 h) on flavonolignans production by High Performance Liquid Chromatography (HPLC) have been studied. Results: Determination and quantification of flavonolignans showed that cell suspension cultures of S. marianum were consists of a large number of flavonolignans including silychristin, silydianin, silybin, isosilybin and taxifolin. The results showed that Yeast extract cause improvement in silymarin content in the media treated with 6 (mg / 50 ml culture) Yeast extract at the end of 72h which was 5- fold to compare the control and the maximum cell Dry weight was 5.82 g in the media treated with 4 mg/ 50 ml culture Yeast extract at the end of 24h. Conclusion: In this experiment it has been observed that cell suspension culture of S. marianum are susceptible to elicitation by Yeast extract and it can be extremely useful in increasing productivities in cell suspension culture of Milk thistle plant.
Hr Ahmadi-Ashtiani , Sh Rezazadeh , E Barkhordari , N Hekmat-Nazemi , M Baghaei , S Bokaie , H Rastegar ,
year 9, Issue 33 (3-2010)
Abstract
Background: As increased outdoor activities of people, they are more exposed to UV radiation, which causes harmful effects on skin. Silymarin has protective potentials against DNA damage and non-melanoma skin cancers, and also it has anti-oxidant, anti-inflammatory, and immune regulation characteristics. Nano formulation of plant material showed to be more effective than common ones.
Objective: In present study, nano-formulated silymarin was used in a cream, and its effects were investigated against destructive effects of UV rays.
Methods: Silymarin standardized extract was prepared, nano formulated in cream base, and applied to skin of the animals. Four groups of animals (n=15) were examined Group 1 without any treatment (control), Group 2 Vaseline, Group 3 nano-formulated silymarin extract cream, and Group 4 silymarin-carnosine. UV was radiated on the shaved area of the four groups for 45 minutes with dose of 180 mJ/cm2. Dermal scaling, skin irregularity, erythema, skin hyperpigmentation, and edema were evaluated in animals. Histopathological observation was done on the skin samples of the animals.
Results: silymarin nano-formulation was effective in decreasing both physical damages and histopathological injuries significantly.
Conclusion: from the observed results, it can be concluded that the cream containing nano-formulated silymarin can prevent UV radiation lesions better than pure silymarin.
Hr Ahmadi – Ashtiani , Mm Naderi, S Bokaii , H Rastegar , Sh Rezazadeh ,
year 9, Issue 33 (3-2010)
Abstract
Background: Studies have shown that Silymarin is one of the infrequent herbal materials which have protective effects against sunburn, non melanoma skin cancer and immunosupression in oral administration. Easiness of use, low cost and availability of Silymarin can propose it for use in many topical sunscreen products. Objectives: Regarding to the skin damages caused by the ultraviolet ray of sun and necessity to use of protective agents against mal effects of this ray, in this study the effects of oral use of Silymarin against effects of UV irradiation was evaluated. Methods: In this study 60 albino guinea pigs were selected and they divided in two equal groups. Animals in the experimental group administered 50 mg/kg Silymarin 20 days before and through the irradiation period orally. Control group received distilled water only. Then each group exposed to 180mj/cm2 UV ray. Finally clinical signs were noted and sampling was done from irradiated skin areas for histopathological evaluation. Results: Histopathological and clinical findings showed that oral administration of Silymarin had protective effects against mal effects of UV irradiation on guinea pig skins. Conclusion: The results of this study can be incentive for introduction and use of this herbal agent in sun ray protective oral products because any topical sunscreen has not perfect protective effects against all UV irradiation spectrums.
Hr Ahmadi Ashtiani , A Allameh , N Hamidipour , H Rastegar , M Soleimani ,
year 9, Issue 34 (5-2010)
Abstract
Background: Mesenchymal stem cells (MSCs), the non-hematopoietic progenitor cells found in various adult tissues are characterized by their ease of isolation and their rapid growth in vitro while maintaining their differentiation potential, allowing for extensive culture expansion to obtain large quantities suitable for therapeutic application. Silymarin has strong antioxidant and anti-inflammatory activities with positive effect on proliferation on some cell types. Objectives: The aim of this study was to find out the optimal condition of silymarin treatments on mesenchymal stem cell growth and multiplication. Methods: Human MSCs in third passage were divided into 12 groups treated by 50, 75, and 100 μg/ml of silymarin for 2, 7 and 14 days. Cell viability was assayed on day 2 using trypan blue exclusion test. The cell proliferation rate in presence of silymarin was determined using a day-response curve for each dose. Results: Viability was 89%, 93%, and 96% for cells treated with 50, 75, and 100µg/ml silymarin, respectively. Cell viability showed significant increase in all treated cells in comparison with the control group (83%). Based on the day- response curve, it was shown that the rate of cell proliferation in treated cells is significantly higher when exposed to silymarin for 2 - 7 days. However, from 7th day to 14th, silymarin exposure lowers hBMSCs proliferation rate compared to control group. Conclusion: Under optimal condition of silymarin exposure time, the rate of MSC proliferation can be stimulated.
Hr Ahmadi-Ashtiani , Sh Rezazadeh , K Safipourian , K Afraz , A Khaki , H Rastegar,
year 9, Issue 35 (9-2010)
Abstract
Background: Alcoholic mothers who consume ethanol give birth to infants with high percentage of hepatic diseases. Alcohol can cause cellular damage in different tissues, including liver. Finding a drug which is effective and efficient in reducing ethanol misuse consequences during pregnancy can assist the decrease of harmful effects of this habit. Objective: This research aims to study the effects of oral administration of silymarin in preventing consequences of ethanol on liver during pregnancy. Methods: 45 female rats were randomly divided into 3 groups, each including 15 ones. After the first day of pregnancy, the study was performed as follows. The first group was given distilled water. The second group received ethanol equivalent to 35% of the total required calorie. Furthermore, the third group received the same amount of ethanol plus 200 mg/kg silymarin. At day 21, biopsy of liver tissue of the born infants was carried out for light microscopy studies. Results: Findings of the present study indicate that, in the group which received ethanol, this extract can have a considerable effect on decreasing the hepatic cellular death as well as reducing hepatic hyperemia. Conclusion: Oral consumption of silymarin extract can reduce the damage and inflammation in liver tissue of infants born from alcoholic mothers.
