Background: Premna mollissima Roth. belong to family Lamiaceae is a small deciduous tree commonly called as dusky fire brand bark. It is distributed in tropical or subtropical climate, often in hilly or forested areas of India, Sri Lanka, Bangladesh and Myanmar. Objective: To summarize a systemic review of the ethno-pharmacology and phytochemical study of P. mollissima Roth. It also includes the therapeutic importance as stated in literature and the pharmacological aspects which have been already explored in the present-day scientific parameters. Methods: An ethno-pharmacological review of P. mollissima was done through the texts, as well as searching research articles related to its pharmacognosy, traditional uses, phytochemistry, and therapeutic activities available on Pubmed, Science Direct, Google Scholars, Scopus, and Web of Science from their dates of inception till present. The following keywords were applied to the literature search “Premna mollissima”, “Agnimantha”, “phytochemistry” to find the description of the plant. Results: Various chemical constituents can be obtained from the plant such as premnine, 7-deacetylpremnine, premnalatifolin, quercetin, etc. The root, leaf and bark is used in Ayurveda and folk medicine for the treatment of different ailments such as dropsy, treatment of edema, boils, fevers, rheumatism, neuralgia, etc. Various studies have indicated its astringent, anti-inflammatory, anti feedant, diuretic, digestive, and antibacterial properties. Conclusion: This study is an attempt to compile an up-to-date and comprehensive review on P. mollissima Roth. covering its traditional and folk medicinal uses, phytochemistry and pharmacology. It will help future researchers to explore more about its active phytoconstituents and pharmacological activities.
