Showing 14 results for Zahedi
S Zahedi-Asl , F Saharnaz , A Ghassemi , B Zaree ,
year 5, Issue 17 (Supplement 2 diabetes 2006)
Abstract
Background & Aims: Diabetes is a common endocrine disorder. Although the most common conventional treatment for diabetes is insulin, the diet therapy approach has many advantages in developing countries. Among many herbs, reported to possess antidiabetic activity, Trigonella foenum graecum (fenugreek) is one of the best in terms of efficiency and safety. The effect of carbon tetrachloride extract of fenugreek on liver glycogen has not been investigated until now. This study was designed to investigate the effect of carbon tetrachloride fenugreek in extract comparison with insulin on liver glycogen.
Materials and Methods: For this purpose we used 3 groups of rats, each containing 10 animals. Stereptozotocin was administered to induce diabetes. One group served as control group, receiving no treatment; in the 2nd group, NPH insulin was administered on 3 consecutive days. For the third group, carbon tetrachloride extract of fenugreek was administered orally for 3 days. Blood glucose was measured before and after intervention. Daily water intake and liver glycogen were assayed at the end of treatment.
Results: The results showed that fenugreek extract, like insulin, caused a significant decrease in blood glucose and daily water intake (P<0.05). A significant increase in liver glycogen, compared with the untreated group, was seen in the insulin and extract treated groups (P<0.05).
Conclusion: In conclusion, the results of this study confirm the benefits of the traditional use of fenugreek for diabetes treatment.
Mh Salehi Surmaghi , Gh Amin , H Zahedi , H Kuchesfahani ,
year 6, Issue 22 (5-2007)
Abstract
Background: One of the essential problems of using medicinal plants which are mostly collected from the wild is their fungus and microbial infections. Nowadays, exposing the plants to Gamma radiation apparently removes the problem. But, as the plants contain outstanding amount of chemical substances, the exposition can lead to a change in the composition of the plants chemicals and therefore a change in their medicinal effects. Making poisonous, carcinogen or stimulant substances in the plants could be examples of this change. Objective: The aim of this research was evaluating effect of Gamma radiation on chemical composition of ten medicinal plants essential oils Mentha, Coriandrum, Foeniculum, Zingiber, Cuminum, Bunium, Melissa, Thymus and Zataria. Methods: Essential oil of the species before and after Gamma radiation were obtained over Clevenger apparatus, analyzed using GC and GC/MS and identified based on RT, KI and authentic references. Results: Results showed that within ten species, the Coriander oil was affected with the 10 & 25 KG of Gamma radiation and changed to the another components. Conclusion: These results of experiment can alert the world, to the threatening consequences of using Gamma radiation concerning human health.
H Hajimehdipoor , Sh Rezazadeh , A Hadjiakhoondi , M Pirali Hamedani , A Rezaee , H Zahedi , N Kalantari Khandani ,
year 6, Issue 23 (9-2007)
Abstract
Background: Passiflora has several species that two of them named P. incarnata and P. caerulea are cultivated in Iran. Many investigations have been carried out on therapeutic effects of the genus but only P. incarnata is approved for use in pharmaceutical dosage forms for anxiety and insomnia. Objective: The purpose of this study is differential determination of P. incarnata and P. caerulea in medicinal plants and related herbal drugs. Method: In this investigation, microscopic properties, total ash, acid-insoluble ash and total flavonoids calculated as hyperoside of P. incarnata and P. caerulea were determined. In addition, TLC chromatogram regarding flavonoids and HPLC chromatograms of P. incarnata and P. caerulea ethanol extract, Passipay tablet and drop (Iran Darouk Co.), Passiflora drop and dry extract (Vogel Co.) and Passiflora drop (Curarina Co.) were also compared. Results: No significant difference between total ash, acid-insoluble ash and total flavonoids in two species were found. But they were very different in microscopic properties. TLC and HPLC chromatograms are very different as well. Conclusion: The aerial parts of the two plant species can be well distinguished by microscopic method. The plant extract either itself or in pharmaceutical dosage forms, can be determined by HPLC or TLC methods. Since sample preparation is very simple and doesn’t require complex procedures, the above-mentioned methods seem to be efficient.
H Hajimehdipoor , H Zahedi , N Kalantari Khandani, Z Abedi , M Pirali - Hamedani, N Adib ,
year 7, Issue 26 (5-2008)
Abstract
Background: Artemisia absinthium L. (common wormwood) has been widely used in traditional medicine. The plant contains toxic components: α and β-thujone, therefore, it should be used with caution. Objective: Since common wormwood is considered to be a toxic plant, we decided to evaluate toxic compounds quantities in those used in Iranian folk market. Method: Five samples were purchased from Tehran markets. Essential oil of the flowers was obtained by water distillation. Essential oils were injected to gas chromatograph and their thujone content were determined according to the calibration curve. Results: The results showed that α-thujone is absent in all samples and β-thujone content in the essential oils is much less than its amount reported from other countries. Conclusion: Since the quantity of toxic compounds are low in the plant growing in Iran, it is proposed that Artemisia absinthium L. can be studied for its some medical uses.
M Jarrahi, M Zahedi , Aa Taherian , H Miladi , H Safakhah ,
year 8, Issue 29 (2-2009)
Abstract
Background: There are some information about antimicrobial and anti-inflammatory effect of Matricaria chamomilla flower oil extract, but there isn’t any information about its effect on linear incisional wound healing. Objective: In this investigation, the effect of Matricaria chamomilla flower oil extract on linear incisional wound healing was studied. Methods: Thirty male Wistar rats were subjected to a linear 3cm incision made over the skin of the back. The animals were randomly divided into 3 experimental groups, as Sham operated, Control (Olive oil) and treatment. Sham group did not receive any treatment. Control group received topical olive oil twice a day from beginning of experiments to complete wound closure. Treatment group were treated topically by M. chamomilla extract dissolved in olive oil at the same time. For computing the percentage of wound healing, the area of the wound measured at the beginning of experiments and the next 2, 5, 8, 11, 14, 17 and 20 days. The percentage of wound healing was calculated by Walker formula after measurement of the wound area. Results: Results showed that there were statistically significant difference between treatment and Control animals (p<0.05) in most of the days. Conclusion: We conclude that the topical administration of M. chamomilla extract has wound healing potential in linear incisional wound model in rats.
H Hajimehdipoor, M Khanavi , H Zahedi , Z Abedi , N Kalantari Khandani , N Adib , M Pirali Hamedani ,
year 8, Issue 31 (9-2009)
Abstract
Background: Thymus is a widely used medicinal plant in food and pharmaceutical industries. Among different species of Thymus, T. vulgaris is used more than other species in therapeutic dosage forms. Objective: This study was conducted to differentiate various Thymus species by TLC fingerprint. Methods: In order to identify and differentiate various species of Thymus, TLC fingerprints of essential oil, dichloromethane, ethylacetate and n-butanol extracts of four available species named T. vulgaris, T. pubescens, T. citriodorus and T. daenensis were obtained and compared with each other. Results: The results showed that the TLC chromatograms of essential oil and n-butanol extract can not be used as differential identification for the above-mentioned species while the ethylacetate and dichloromethane extracts are more reliable to be used for TLC fingerprints. TLC chromatogram of ethylacetate extract is specific for identification of T. pubescens and T. vulgaris while T. citriodorus and T. daenensis can be best identified by their TLC fingerprints obtained from dichloromethane extract. Conclusion: For best differentiation of various Thymus species, different extracts of the plants should be used.
Aa Khaki , A Khaki , Hr Ahmadi-Ashtiani , H Rastegar , Sh Rezazadeh , D Babazadeh , A Zahedi , Z Ghanbari ,
year 9, Issue 33 (supplement 6 2010)
Abstract
Background: Antioxidants have essential effect on tissue regeneration after cells injury. Enhanced oxidative stress and changes in antioxidant capacity are considered to play an important role in the pathogenesis of chronic diabetes mellitus. Ginger rhizome and carrot seed are strong antioxidants and long-term treatment of Streptozotocin induced–diabetic animals with these herbs, has been shown to reduce oxidative stress.
Objective: Evaluation to treatment effect of Ginger rhizome and extract of carrot seed on nephropathy after diabetes inducement.
Methods: Wistar male rat (n=70) were allocated into seven groups, control group, carrot seed extract group, ginger group, control- Diabetic group received 55mg/kg (IP) streptozotocin (STZ), treatment diabetic group that received carrot seed extract, treatment diabetic group that received ginger and treatment diabetic group that received carrot seed extract plus ginger. Animals were kept in standard condition. In 30 day after inducing diabetes, 5ml blood were collected for analyzing of TAC and MDA levels, and kidney tissues of Rats were removed in all groups then prepared for analysis.
Results: Pathological changes in diabetic group which received carrot seed and ginger together was decreased compared to control group. The rate of serum TAC significantly increased in diabetic groups which received carrot seed and ginger together significantly in comparison to control-diabetic group (p<0.05).
Conclusion: Since in our study 25 mg/kg carrot seed extract and 100 mg/kg ginger have prevented kidney tissue injury by reducing level of Reactive Oxygen Species (ROS) in serum, so it seems that using it can be effective for treatment nephropathy in Diabetic rats.
A Zahedi , A Khaki , Hr Ahmadi-Ashtiani , H Rastegar , Sh Rezazadeh ,
year 9, Issue 35 (9-2010)
Abstract
Background: Ginger rhizome (Zingiber officinale R., family: Zingiberaceae) is used medicinally and as a culinary spice and has anti-oxidant and cell-protective effects in animals and humans body. Objective: The aim of this study was to investigate the influence of Ginger rhizome toxicity of Gentamicin on sperm parameters in male rats. Methods: Forty Wistar male rat (n=40) were allocated into four groups, control (n=10) and test groups (n=30), that subdivided into groups of 3 that received ginger rhizome powder (100 mg/kg/day), gentamicin group that received, 5 mg/kg/day and ginger group that received, 5 mg/kg/day gentamicin additionally, for 30 consequence day. Animals were kept in standard conditions. In thirty day the testes tissue of Rats in whole groups were collected. Results: Ginger administration caused a marked increase in the testosterone concentrations of the rats even in spite of receiving 5 mg/kg/day gentamicin in compared with the control and gentamicin treated groups. Conclusion: Ginger rhizome is able to overcome reproductive toxicity of gentamicin and induces spermatogenesis probably mainly through the elevation of testosterone levels.
M Ghanbari , M Zahedi Khorasani , A Vakili ,
year 11, Issue 43 (8-2012)
Abstract
Background: Ferula persica has been used in traditional medicine for treatment of high blood pressure. In this study acute and chronic effect of aqueous F. persica extract on BP of hypertensive rats and its possible mechanism of action have been investigated.
Methods: Eighty two male Wistar rats were divided into 12 experimental groups. Hypertension was induced by Goldblatt method in the anesthetized rats. Aqueous extract of F. persica (15 or 30 or 60 mg/kg, iv) or it’s vehicle were administered in treatments or control groups to evaluate their effects on BP and heart rate. To assess the mechanism of F. persica action on BP, L-NAME (5 mg/kg), Atropine (1 mg/kg) or Indomethacin (5 mg/kg) were injected intraperitoneally followed by intravenous administration of F. persica (30 mg/kg) in the different groups of hypertensive rats. Chronic effect of F. persica (30 mg/kg) on BP was evaluated by the aqueous extract administration in drinking water for a month.
Results: Intravenous administration of F. persica reduced BP of hypertensive rats (p<0.001). There is no significant different between three doses of F. persica. Intraperitoneal injection of L-NAME, Atropine or Indomethacin has no significant effect on basal BP, but L-NAME eliminated and Atropine reduced hypotensive effect of F. persica extract on BP. Chronic administration of F. persica has no effect on BP.
Conclusion: Our findings showed the hypotensive effect of F. persica in hypertensive rats may be mediated by muscarinic receptors and NO release.
S Momen Abadi , Hr Sameni , M Zahedi Khorasani , A Vakili ,
year 14, Issue 56 (12-2015)
Abstract
Background: Hypertension is a health problem and alternative medicine is offered for its controlling.
Objective: Nutritional effects of Lavandula angustifolia L. (lavender) oil on high blood pressure (BP), and histological changes of the aorta in rat has been investigated in this study.
Methods: Therty five male wistar rats were divided into 5 groups; normal, hypertensive and control. Hypertension was induced by daily L-NAME administration in drinking water for 6 weeks and lavender oil (500 mg/kg) or its vehicle was given orally simultaneously. After basal BP measurement, lavender (50 mg/kg, iv) was injected in control groups. Histological evaluation of the thoracic aorta included staining with hematoxylin-eosin and orcein methods.
Results: Hypertension induction increased mean arterial BP from 106 to 177 mm Hg and lavender treatment reduced it to 140 mm Hg (P< 0.001). Lavender had no effect on normal rats. Intravenous injection of lavender reduced BP about 75% in normotensive and hypertensive rats (P<0.001). Hypertension induction increased cross-section area, aorta and media thickness, and reduced elastic lamina thickness (P<0.001). Lavender treatment reduced cross-section area of the aorta and media thickness, and increased elastic lamina thickness (P < 0.05). Hypertension and treatment had no effect on advanthia and elastic lamina numbers.
Conclusion: Nutritional lavender oil prevented BP increases and pathological changes of the aorta in hypertensive rats. It seems lavender oil is beneficial for prophylaxis of hypertension.
M Firozi, T Zahedifard,
year 15, Issue 60 (10-2016)
Abstract
Introduction: Dysmenorrhea is one of the most common complaints. Due to the importance and prevalence of dysmenorrhea research is necessary in this regard. Aim: This study aimed to determine the status of herbal medicine in the treatment of primary dysmenorrhea. Methods: In this descriptive study, 117 women admitted to health centers in Mashhad were recruitment. Research tools were personal questionnaire form, information of menstrual in three-month sequential, Verbal multidimensional scale. The data collected by SPSS software using Chi-square and Descriptive Statistics were analyzed. Results: The results showed that 21.4 percent of participants used only herbal medicines and 21.4 percent used herbal and chemical medicines. A total of 11 kinds of herbs used by participants in the treatment of dysmenorrhea. Herbal medicines with the highest frequency were: Cumin cyminum, Anethum gravolens, Black cardamom, Shirazi Thymus Vulgaris , peppermint. According to the chi-square test there was a significant difference between severity of Pain menstrual and type of menstrual pain treatment(p= 0/003). According to the chi-square test there was not a Significant differences between age, occupation, education, age of menarche and menstrual pain relief method. Conclusion: The results suggest that about 50 percent of study participants used herbal medicines as a single therapy or supplement chemical medicines. Due to the widespread use of herbal medicines in the study population, safety, effectiveness, suggestion and availability of effective drugs is recommended.
Faezeh Tahershamsiabstract: Background: Proper Nutritional Support Is One of the Important Caring Aspects I, Korosh Rezaei, Sharareh Khosravi, Zahedin Kheyri, Mohammad Reza Memarzadeh, Fatemeh Rafiei,
year 17, Issue 68 (12-2018)
Abstract
Background: Proper nutritional support is one of the important caring aspects in patients who were hospitalized in ICU.
Objective: This study was done to investigate Oral Drop Gastrolit effect on the gastric residual volume (GRV) in mechanically ventilated patients hospitalized in ICU.
Methods: In this clinical trial, 50 mechanically ventilated patients were recruited using convenience sampling method; and were randomly divided into two control (Placebo = water) and experimental groups (Gastrolit). Intervention group patients were given Gastrolit (20 drops) three times a day for 4 days. GRV was measured before the gavages. The mean GRV of patients were compared in the two groups for 4 days. Data were analyzed using the independent t-test, Chi squared test, and Mann Whitney u test and Friedman test in the SPSS-16.
Results: The results showed that most patients were male (60%), and their mean age ± SD were 63.06±19.6. GRV decreased in the intervention group but increased in the control group. The mean GRV in the intervention group on the second, third, and fourth day significantly lower than the control group (P<0.0001).
Conclusion: It seems Gastrolit can decrease GRV in mechanically ventilated patients, so it can be used to improve gastric emptying and prevent delayed gastric emptying complications.
Zahra Sargazi Moghadam, Nasrin Moshtaghi, Ahmad Sharifi, Asma Zahedi, Azade Khadem,
year 21, Issue 81 (3-2022)
Abstract
Background: Thalictrum minus L. is a medicinal plant contains berberine, which is used for complementary treating of some diseases. Excessive harvesting of this species from rangelands to extract the alkaloid has endangered its survival. Objective: This study was aimed for in vitro propagation of this species and berberine production. Methods: The seeds were germinated at in vitro culture conditions. Then, the leaves were used as explants for callus induction in two MS and LS basal media supplemented with BA (0, 0.1, 0.5 and 1 mg/L) in combination with different concentrations of auxins, NAA, 2,4-D or IAA. Results: The results showed that MS medium with the plant growth regulator combination of 0.5 mg/L BA and 0.5 mg/L NAA had the highest callus formation and 100 % regeneration. Some calli were transferred to three liquid culture media (MS, LS, or ½ MS) with 1 mg/L BA + 0.1 mg/L NAA or without plant growth regulator to produce the berberine. The HPLC results identified 6 % of berberine in the liquid medium. This amount of berberine can be easily released into the culture medium, therefore, it will be easier to extract. Conclusion: This method can be successfully used for propagation and extraction of berberine without plant destruction.
Maryam Zahedifar, Sharareh Najafian,
year 22, Issue 87 (12-2023)
Abstract
Background: In sustainable agriculture, reduction of chemical fertilizers- induced environmental pollutions is mainly considered. Therefore, recently application of organic fertilizers particularly their foliar applications received increased attention. Besides, herbal medicine with higher antioxidant activity will be able to limit the formation of free radical species. Objective: Therefore, we aimed to determine the effect of foliar application of organic fertilizers on antioxidant activity and polyphenolic compounds of Marrubium vulgare L. in greenhouse experiment. Methods: In a completely randomized design experiment with three replications that was carried out in 2019, the applied treatments consisted of four levels (0, 250, 500, and 1000 mg L-1) of foliar application of humic and fulvic acids (0, 250, 500, and 1000 mg L-1). Some phenolic compounds including gallic acid, chloregenic acid, coumarin, hesperidin, and eugenol were detected and quantified in the Marrubium vulgare L. extracts. Results: Application of 250 mg humic acid L-1 resulted in the highest extraction of phenolic compounds, coumarin, reducing this content at a higher applied level and by fulvic acid addition. As such, the foliar application of low concentrations of humic acid before the flowering stage was a useful and effective method to increase the synthesis of phenolic compounds. Among the studied organic acids, the application of 250 mg humic acid L-1 showed the highest antioxidant activities. These compounds can be effective in controlling diseases with free radicals. Conclusion: Based on the findings of the present research, a more appropriate management of the growth and propagation of medicinal plants and their quality can be applied. In addition, humic substances application reduces the chemical fertilizers used, thereby maintaining the environment.
