Ah Hedaryan, M Hamidpour, Am Ayatolahi, M Allah Bakhshian Farsiani,
year 18, Issue 70 (5-2019)
Abstract
Background: Coagulation activity of platelets plays an important role in thrombosis formation, Atherosclerotic plaque establishment and cardiovascular disorders. ASA are using as an anti platelet activity drug for patients with Coronary Artery Disease (CAD). Using of plant extraction as a complementary medicine for these patients (CAD) is mostly recommended by traditional medicine specialist.
Objective: In this study we investigated platelet activity after treatment with extract of Artemisia dracunculus (Tarragon) and it’s synergic with ASA treatment.
Methods: After preparation of platelets from healthy volunteers, platelets confronted with desired concentrations (125-1000 µg/ml) of methanol extract of Artemisia dracunculus (tarragon) and (0.31-1.26 µg/ml) of (ASA) alone and in combination. The platelet function such as adhesion, aggregation and protein release were assayed on treated platelets and controls.
Results: Our results demonstrated that Tarragon extract significantly effective on adhesion, aggregation and protein release in comparison with healthy volunteers platelets (P≤0.001). The Tarragon extract also raised the anti-platelet activity of ASA on these platelets.
Conclusion: Tarragon extract, either as single agent or combination with ASA, has been able to induce anti-platelet activity. Therefore, it would be suggested to use of the tarragon extract with or without common treatments, i.e. ASA, in treatments of cardiovascular disorders and patients with deep vein thrombosis.
Mahdieh Mehrpouri, Rafie Hamidpour, Mohsen Hamidpour,
year 19, Issue 73 (3-2020)
Abstract
Background: Cinnamon belongs to the Lauraceae family and is one of the most common spices that are used as traditional medicine in the world. The bark and leaf of cinnamon contain essential oils and derivatives including cinnamaldehyde, cinnamic acid and several other compounds such as polyphenols. Moreover, anti-inflammatory and lipid lowering properties of cinnamon has been proven. Objective: The goal of this review is to find out whether cinnamon extract was used as an anticoagulant and anti-aggregation properties for the platelets or not. Methods: Using the search engine tools such as PubMed and Scopus, the articles that were studied cinnamon and its effects on platelets function and cardiovascular disease were under reviewed. Results: This article presents a comprehensive analysis of cinnamon compounds and their effects on platelet function and cardiovascular disease. Conclusion: Taken together, data show that cinnamon extract can inhibit platelet function and as a complementary medicine were used in cardiovascular disorder.
