Showing 6 results for Ghobadi
Gh Amin , Mm Ahmadian - Attari , Mr Fazeli , H Jamalifar , H Ashtiani , A Ghobadi , R Shakiba , M Khanlarbeik ,
year 7, Issue 25 (Supplement 4 2008)
Abstract
Although many compounds have already approved for use in food as antimicrobials, research for finding greater number of these compounds are still interesting because most currently approved food antimicrobials have limited applications due to food compound interactions. Finding new food antimicrobials requires expensive investigations. Traditional herbal antimicrobial agents like sumac can play an important role. If it is demanded to promote sumac to the rank of a food antimicrobial agent, its stability and interactions must be evaluated. The evaluation of sumac heat stability was done by measuring MICs and MBCs of the extract against some food- related bacteria in extreme condition of autoclaving. The main components of sumac extract are tannic compounds. Tannins have interactions with salt and proteins, and they become sediment in such conditions. Antimicrobial activities of the extract were measured by well diffusion method in the presence of salt and protein and compared with the activities of pure extract. The results show that sumac is heat stable but has interactions with salt and proteins that reduce its activity against Gram- negatives.
R Mohammadi , Ma Zarei , S Ghobadi ,
year 15, Issue 58 (4-2016)
Abstract
Background: Using of acetylcholinesterase inhibitors is one of the methods for treatment of Alzheimer disease currently. Plants are rich sources for many bioactive compounds. So searching for new drugs with better properties and fewer side effects from plants is the aim of many studies.
Objective: The purpose of this study was to investigate acetylcholinesterase activity inhibition by methanol extract of the aerial parts of screened plants, Alcea kurdica (Schlecht.) Alef and Astragalus glumaceus Bioss.
Methods: Using a modified version of Ellman’s microplate assay method, acetylcholinesterase inhibitory activity of methanol extracts from various aerial organs (flowers, stems, leaves) of plants Alcea kurdica and Astragalus glumaceus at four different concentrations were investigated. Electric eel acetylcholinesterase was used in this study. Galanthamine, dissolved in methanol, used as a positive control and each experiment was done in triplicate.
Results: The results revealed that the methanol extract from flower organ of Alcea kurdica and leaves of Astragalus glumaceus, at 2 mg/ml concentration, inhibited the enzyme activity with 63.45 and 53.58 inhibition percent respectively. Their IC50 values were 0.114 and 0.216 mg/ml respectively. According to the results enzyme inhibition kinetics analysis, methanol extract from flower organs of Alcea kurdica and leaves of Astragalus glumaceus showed competitive and mixed (competitive – noncompetitive) inhibition, respectively.
Conclusion: These results suggest that the most effective plant’s organ extracts in this study, be worthy of further investigation with the aim of obtaining new acetylcholinesterase inhibitors with pharmacological applications.
Amir Hossein Jamshidi, Fatemeh Eghbalian, Somaye Mahroozade, Hoorieh Mohammadi Kenari, Ali Ghobadi, Bahare Sadat Yousefsani,
year 19, Issue 75 (9-2020)
Abstract
Background: Alzheimer's disease is the most common cause of dementia, especially in elderlies. Its exact pathogenesis is not yet known and existing therapies do not have enough efficacy. Therefore, the use of complementary therapies such as traditional Persian medicine for improving memory function is increasing. Objective: The aim of this study is evaluating recommended natural products in important traditional Persian medicine textbooks. Methods: For this purpose, keywords such as "Nesyan" (ie: oblivion, amnesia), "Hafezeh" (ie: memory), "Zekr" (ie: mention) and "Faramoushi" (ie: forgetfulness( were used to search in recommended prescription in important traditional Persian medicine textbooks. Then, the most repeated plants were extracted from the prescription and evaluated for their pharmacological properties recently published articles cited in the scientific databases such as Google Scholar, PubMed, Medline, and Scopus. Results: 262 natural products were in 96 evaluated prescription, 40 natural products were more repeated. These products were introduced in the table. Besides, their neuroprotective effects, antioxidant effects, and anti-Alzheimer's disease effect were also included in the table. Conclusion: Based on these results, traditional Persian has introduced many treatments for Alzheimer's disease, which requires clinical studies to prove or disprove their efficacy and safety.
Hoorieh Mohammadi Kenari, Bahare Sadat Yousefsani, Fatemeh Eghbalian, Ali Ghobadi, Amirhosein Jamshidi, Somaye Mahroozade,
year 20, Issue 77 (1-2021)
Abstract
Background: The outbreak of COVID-19 has spread quickly all over the world. Apparently, the uncontrolled increases in the inflammatory and the immune processes are its major pathologies. Therefore, the use of natural plants containing antioxidant factors for the regulation of the immune system can be useful for the inflicted patients. Many epidemic diseases have occurred throughout human history. Persian physicians such as Avicenna offered solutions to these epidemics that were helpful in controlling these diseases. Objective: In this study, we introduce the herbs according to traditional Persian medicine’s point of view that confirm their having antitussive, antipyretic, anti-viral, anti-inflammatory and antioxidant effects. Methods: In this regard, a thorough search was done on the detoxifier and immuno-modulatory plants in the Persian medicine books such as Makhzan-ol Advieh” and “Tohfat ol momenin” and “Qanun fi al tib”. Then, the herbs that were effective in fever and pulmonary diseases were browsed and arranged, and their pharmacological properties were also searched in the scientific databases. Results: This study examined the antipyretic, antitussive and immune-enhancing properties of the plants cited in Persian medicine books and showed that plants such as orange, sweat lemon, citron, myrtle and lavender have antipyretic, antitussive, anti-inflammatory, antioxidant and antimicrobial properties. Conclusion: It seems that the introduced plants could be potential candidates for animal studies and clinical trials. However, more studies are needed to prove their specific effectiveness.
Bahareh Sadat Yousefsani, Ali Ghobadi, Kobra Shirani,
year 23, Issue 89 (3-2024)
Abstract
Background: Garlic, scientifically known as Allium sativum, has been a revered traditional medicine for millennia, rich in diverse phytochemicals with various medicinal properties, such as antioxidant, anticancer, anti-inflammatory, pain killer, hypoglycemic, antimicrobial, antiviral, and wound-healing properties. Its remarkable therapeutic potential makes garlic a beneficial natural treatment for many health issues. Objective: This research examined the neuroprotective effects of garlic against Malathion (Mal)-associated Parkinson's-like behavioral symptoms in rats. Methods: Animals were categorized into eight groups at random: (1) saline-treated group (control); (2) Mal group (100 mg kg⁻¹); (3) Mal + garlic (50 mg kg⁻¹); (4) Mal + garlic (100 mg kg⁻¹); (5) Mal + garlic (150 mg kg⁻¹); (6) Mal + L-DOPA (10 mg kg⁻¹); (7) garlic (150 mg kg⁻¹); and (8) polyethylene glycol (PEG) group (L-DOPA vehicle). Treatment lasted 28 days, followed by behavioral assessments and analyses of acetylcholinesterase (AChE) activity, malondialdehyde (MDA) level, antioxidants levels, and proinflammatory cytokines in the striatum. Results: Mal exposure caused neurobehavioral toxicity with increased MDA, tumor necrosis factor-α (TNF-α), and interleukin-6 (IL-6), alongside decreased GSH concentration and AChE activity. Garlic treatment successfully mitigated these effects. Conclusion: The findings suggest that garlic may have a favorable impact in treating Parkinson's disease by enhancing antioxidant levels and mitigating oxidative stress and inflammatory processes, countering the harmful effects of pesticides like Mal. Additional studies necessary to thoroughly explore garlic's protective benefits in this area.
Marziye Bayat, Amirhossein Jamshidi, Hoorieh Mohammadi-Kenari, Ali Ghobadi,
year 24, Issue 93 (5-2025)
Abstract
Background: Barberry (Berberis L.) is a well-known fruit traditionally used in various ethnomedical systems, including Ayurveda and Traditional Persian Medicine (TPM), for its nutritionaland therapeutic properties. Objective: This study aims to provide a comprehensive overview of the traditional medicinal uses, phytochemical composition, and pharmacological effects of barberry. Method: A systematic review was conducted by examining traditional Persian medicine texts and electronic literature on traditional medicine. Additionally, electronic databases were searched for scholarly articles focusing on the pharmacological activities and phytochemical components of barberry. Results: Phytochemical analysis revealed the presence of essential oils, micronutrients, macronutrients, phytosterols, and various phenolic compounds. Pharmacological studies demonstrate that barberry possesses diverse biological activities, including anti-cancer, antioxidant, cardiometabolic protective, antimicrobial, hepatoprotective, anti-inflammatory, anxiolytic, nootropic, and neuroprotective effects. Conclusion: Although barberry shows promising therapeutic potential, further clinical trials and meta-analyses are required to confirm its efficacy in medical applications.
