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Showing 7 results for صفری

Gholamali Naderi, Sedigheh Asgary , Mohsen Ani , Nazal Sarrafzadegan , Mahmoodreza Safary ,
year 1, Issue 1 (3-2002)
Abstract

Accumulating evidence shows high plasma levels and preoxidation of LDL display the key role in atherogenesis. When LDL is oxidized, the affinity of LDL to its receptor is decreased and via scavenger receptor on macrophages is being taken off. The resultant accumulation of ox-LDL in macrophages leads to the appearance of foam cells and fatty streak formation in the subendothelial cells of arterial wall. In this study, antioxidant properties of eight natural volatile oils include: Geraniol, Thymol, Pulegone, P-cymol, Linalool, Limonene, Eugenol, Anethol and its effect on the affinity of native and oxidized-LDL to its receptor in bovine adrenal cells have been investigated in the presence of fluoresein isothiocyanate-labled-LDL. The results show that between volatile oils used in the study Eugenol and Thymol are the best compounds that were increased the affinity of native and oxidized LDL to its adrenal cells receptor. The effect of these compound on oxidized LDL is Thymol> Eugenol> Geraniol> Limonene> P-Cymol> Linalool> Anethol> Pulegone. And on native LDL is Eugenol> Thymol> Linalool> P-Cymol> Limonene> Geraniol> Pulegone> Anethol. These results indicate that, volatile oils especially Thymol and Eugenol have antioxidant properties and probably via its lipophylic effect and effect on the LDL particles changed the affinity of LDL for its receptor. However, deeper and more studies are warranted to use such compounds for clinical usages especially atherosclerosis and cholesterol reduction.

Mr Safari , N Sheikh , Kh Mani-Kashani ,
year 1, Issue 3 (9-2002)
Abstract

Diabetes mellitus is one of the most common diseases in the world that imposes a tremendous health and societal burden whether that burden is measured in terms of sickness, use of health systems resources or costs. Hyperglycemia is the most important clinical sign of diabetes leading to glycation of the various proteins in the body that leading to change in nature, structure and biochemical activity of them. On of the probable method in the treatment of diabetes mellitus is decreased or inhibited this reaction, it seems that essential oils are useful for this purpose. The main goal of this research is to determine the effect of some essential oils such as: Pulegone, Thymol, Geraniol, Linalool and Limonene on in vitro albumin glycation. In the presence of various concentration of essential oils albumin was glycated and evaluated using TBA method. Results showed that these essential oils have inhibitory effects on albumin glycation reaction with the concentraction of 1 g/dl, 0.2 g/dl and 0.1 g/dl. Among these essential oils, Thymol had the most inhibitory effect (94%) in the concentration of 1 g/dl. The sequence of effect is: Thymol > Geraniol > Pulegone > Limonene > Linalool These findings showed that essential oils decreased albumin glycation reaction.

N Sheikh, Mr Safari, M Araghchian , F Zeraati,
year 2, Issue 7 (9-2003)
Abstract

Diabetes mellitus is one of the most common diseases in the world that imposes a tremendous health and social burden whether that burden is measured in terms of sickness, use of health systems resources or costs. Hyperglycemia is the most important clinical sign of diabetes leading to glycation of the various proteins in the body that leading to change in nature , structure and biochemical activity of them. One of the prevention method in the treatment of diabetes mellitus is decreased or inhibited this reaction, it seems that food additives are useful for this purpose. The main goal of this research is to determine the effect of some food additives such as: Somaq, Cinnamomum and Black Pepper on in vitro albumin glycation. In the presence of various concentration of food additives albumin was glycated and evaluated using TBA method. Results showed that these food additives have inhibitory effects on albumin glycation reaction with the concentration of 1g/dl, 0.2g/dl and 0.1g/dl. Among these food additives, Somaq had the most inhibitory effect (80.8%) in the concentration of 1 g/dl. The sequence of effect is: Somac > Black pepper > Cinnamomum These finding showed that food additives decreased albumin glycation reaction.

Ar Zebarjadi, M Safari, K Cheghamirza,
year 16, Issue 61 (supplement 10 2017)
Abstract

Background: Licorice, Glycyrrhiza glabra (belong to Leguminosae family) is one of the most popular medicinal plants in the world and it is widely used in many fields such as medical, pharmaceutical, confectionery and health industries. Different parts of licorice (shoots, leaves and roots) were had various components such as Glycyrrhzin that was used for some proposes.

Objective: The current study was done with the aim of gene transfer via Agrobacterium rhizogenes by ex vitro method for hairy root production in licorice.

Methods: The experiment was laid out as a completely randomized design (CRD) with five treatments in three replications. At first, root of young plantlets was eliminated and excited plantlets were putted in the glass wool contain suspension of bacteria. After 10 to 14 days of inoculation with Agrobacterium rhizogenes, the roots were appeared. The percentage of root induction by four strains of Agrobacterium (ATCC 15834, GMI 9534, A4 and A13) with check (without bacteria) was investigated.

Results: The results of PCR analysis with specific primers for roots of composite plants (putative transgenic) was shown that three strains of bacteria (A4, A13 and GMI 9534) and strain ATCC 15834, were produced 100% and 66.66% transgenic roots respectively.

Conclusion: Thus, production of composite licorice plants was remarked due to it has low cost, fast and simple.


Fatemeh Mirabdollahi Shamsi, Razieh Najjari, Ali Moradi, Fatemeh Safari,
year 18, Issue 72 (Supplement 12 2019)
Abstract

Background: Hypertension induced-left ventricular hypertrophy (LVH) is, at least initially, an adaptive response of the heart to pressure overload but it leads to heart failure if left untreated. Over-activity of reactive oxygen species generator, NADPH oxidase enzyme, is intricately linked with LVH progression.
Objective: The aim of the present study was to investigate the effect of, natural polyphenole, resveratrol on transcription level of NADPH oxidase subunits (gp91Phox, P22Phox, P67Phox, P47Phox and Rac1) in hypertrophied heart of rats.
Method: Male Wistar rats were divided into the following groups: control (intact animal); sham (DMSO+H), untreated hypertrophy (H) and resveratrol-treated hypertrophy (R+H) groups. LVH was induced by abdominal aortic banding. Blood pressure was measured directly through carotid artery cannulation. Gene expression was evaluated using real time RT-PCR technique.
Results: The animals in H group had higher systolic (SBP) and diastolic blood pressure (DBP) compared with control (P <0.001). In treated group (R+H) SBP and DBP were decreased significantly in comparison with H group (P <0.001). In H group, cardiac mRNA levels of gp91Phox, P22Phox, P67Phox and Rac1 subunits levels were upregulated by 98.4 ± 14.5%, 64.7 ± 8.8%, 36.4 ± 5% and 73.2 ± 10.8% ,respectively (P < 0.001, P < 0.001, P < 0.05 and P < 0.001, respectively vs. control). However in R+H group gp91Phox, P22Phox and Rac1 mRNA levels were 43.2 ± 4.5%, 28.6 ± 5.7% and 30.5 ± 5.8% which showed a significant difference compared with H group (P < 0.01, P < 0.05 and P < 0.05, respectively).
Conclusion: Transcription level of NADPH oxidase subunits increases in hypertrophied heart. Resveratrol protects the heart against pressure overload-induced LVH partly through downregulation of NADPH oxidase subunits.

Narges Pournaghi, Farahnaz Khalighi-Sigaroodi, Elahe Safari, Reza Hajiaghaee,
year 19, Issue 76 (11-2020)
Abstract

Background: Many herbal remedies have been used in medical systems for the cure of diseases. One of these important applications is usage of them as cytotoxic agents for the treatment of cancers and tumors. Various studies have been conducted on several species of Caesalpinia genus including evaluation of antimicrobial, antitumor, anti-inflammatory, antipsoriatic, antidiabetic, antioxidant, antibacterial, immunomodulatory and hypoglycemic activities. Some reports have shown that these plants contain phytochemicals like polyphenols, glycosides, terpenoids, saponins and flavonoids. Objective: The aim of this study was to find species of the Caesalpinia genus containing diterpene compounds with the structure cassane and norcassane with emphasis on cytotoxic properties. Methods: In this study, keywords including Caesalpinia genus, cytotoxic and anticancer effects, and cassane and norcassane compounds were searched in Scopus and Science Direct databases. Results: Thirteen Caesalpinia species were investigated for phytochemical composition and biological effects. Different plant parts of the species including leaves, seeds, stems, roots and legumes contained diterpenes. Among these species, the cytotoxic effects on different cancer cell lines have been evaluated and some had significant cytotoxic effects. Conclusion: Present study show that Caesalpinia genus has valuable cytotoxic activity but further studies are needed to investigate the active components and their possible development as new anticancer drugs.

Leila Ghassemifard, Saeed Sardari, Hajar Safari, Hajar Ramezanikhah, Narjes Khavasi,
year 21, Issue 83 (9-2022)
Abstract

Background: Capparis spinosa L. due to its anti-inflammatory and antioxidant properties plays a key role in preventing and treatment of cancer, also reduces the growth rate of cancer cells. This plant can be used in various ways in medicinal compounds, food, etc. as an extract, oil, or essential oil. Objective: In the current study, the rate of antioxidant activity extracts and oils (cold press and n-hexane oils) of Capparis seeds and also the effect of the seeds on the SH-SY5Y cell line have been investigated. Methods: First, extract, cold press, and n-hexane oils were prepared; then all reached concentrations of 50, 100, and 200 mg/ml, and their antioxidant capacity was evaluated by the 2,2-diphenyl-1-picrylhydrazyl (DPPH) method. After that, the number of antioxidant compounds in the extract was measured, and finally, the toxicity of the extracts was evaluated by the (3-(4,5-dimethylthiazol-2-yl)-2,5-diphenyltetrazolium bromide (MTT) method on SH-SY5Y cancer cells. Results: The IC50 data showed that the antioxidant activity of the Capparis seeds extracts was significantly (P < 0.001) increased compared to cold press and n-hexane. Antioxidant compounds analysis of Capparis seeds extract indicated high rate of total phenolic, flavonoid as rutin, and quercetin. MTT assay demonstrates that Capparis seeds extracts in a concentration of 1000 μg/ml decreased the viability of the SH-SY5Y cancer cell lines in comparison with hacked cells (P < 0.001). Conclusion: The seed extract of Capparis seeds at high concentrations, probably due to its high antioxidant content, inhibits the growth of SH-SY5Y cancer cells.


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