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2- Department of Midwifery and Reproductive Health, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran ,
3- Department of Anatomical Sciences, Faculty of Medical Sciences, Tarbiat Modares University, Tehran, Iran
4- Reproductive Endocrinology Research Center, Research Institute for Endocrine Sciences, Shahid Beheshti University of Medical Sciences
Background: Increased oxidative stress in women with polycystic ovary syndrome attracted attentions to antioxidant treatments. Calligonum Comosum is a planet with antioxidant propertis.
Objective: This study aimed to investigating Calligonum effect on polycystic ovarian histology of polycystic ovary mouse model.
Methods: Thity two female NMRI mice with 25-30 gr weight and 8 weeks age were investigated. A single dose of estradiol valerate (40 mg/kg; im) was used for induce polycystic ovarian morphology. Calligonum Comosom extract (20 mg/kg/ week; ip) was injected for 4 consequent weeks. In sham group, only DMSO was used. After 4 weeks, blood and histological samples were prepared to study.
Results: There was no significant effect of 20 mg/kg Calligonum on polycystic ovarian morphology mouse model.
Conclusion: The effect of other doses of Calligonum Comosum on fertility or adverse effect of this planet need to be more investigated.
Received: 2015/03/2 | Accepted: 2015/05/31 | Published: 2015/12/1
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