year 23, Issue 91 (8-2024)
J. Med. Plants 2024, 23(91): 28-41 |
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Terangpi R, Yasmin F. Exploring abortifacient perspectives on the use of Achyranthes aspera L. and Dendrocalamus hamiltonii Nees & Arn. ex Munro among Karbi tribe of Assam, Northeast India. J. Med. Plants 2024; 23 (91) :28-41
URL: http://jmp.ir/article-1-3649-en.html
URL: http://jmp.ir/article-1-3649-en.html
1- Department of Botany, Gauhati University, Guwahati-781014, India; Department of Botany, Barnagar College, Sorbhog-781317, India , reenaterangpi@barnagarcollege.ac.in
2- Department of Botany, Nowgong College (A), Nagaon-782001, India
2- Department of Botany, Nowgong College (A), Nagaon-782001, India
Abstract: (416 Views)
Background: The Karbi, an indigenous tribe of Assam, uses ethnomedicinal plants for unintended pregnancies. Objective: The present study describes two important ethnomedicinal plants (Achyranthes aspera L. and Dendrocalamus hamiltonii Nees & Arn. ex Munro) for inducing abortion and its physicochemical and phytochemical characterization. Methods: Physicochemical analysis performed by simple determination techniques. Results: The parameters in physicochemical analysis revealed that plants are potential source of phytomedicine. The pH are slightly acidic to alkaline, signifying good value for oral administration; moisture content are in the acceptable range; highest in A. aspera (8.9%). The total ash content is highest in A. aspera (6.89 %), and higher water soluble ash (20%) signifies presence of water soluble active compounds. The value of Carr’s index and Hausner ratio indicates the powder drugs signify good powder compressibility. Active phytocompounds identified in the plants like Methyl glyoxal, Arsenous acid tris (trimethylsilyl) Ester and phenol, 3-Phenoxypropionic Acid, showed potential reproductive and developmental toxicity. These compounds can be predicted as a candidate drugs as per SwissADME drugs parameters (GI absorption, BBB access, Bioavailability, P-gb substrate and drugs likeness). Conclusion: The knowledge of dosing and handling of the medicinal plants are cautiously practiced by the tribe and physicochemical properties helped to understand the nature and quality control of the herbal formulations. The ADME parameters of the compounds shows drugs likeness properties as per bioavailability radar and thus the compound identified in this two plants can be predicted as an orally active plant based drugs likely to be used as abortifacient agents.
Keywords: Medicinal plants, Unintended pregnancy, Bioactive compound, Orally active drugs, Karbi tribe, Bioavailability
Druglikeness
Type of Study: Research |
Subject:
Medicinal Plants
Received: 2024/04/6 | Accepted: 2024/11/3 | Published: 2024/12/30
Received: 2024/04/6 | Accepted: 2024/11/3 | Published: 2024/12/30
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