year 17, Issue 68 (12-2018)                   J. Med. Plants 2018, 17(68): 32-40 | Back to browse issues page

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Vanaky B, Shakeri N, Nikbakht H A, Farzanegi P. The effect of 6 weeks swimming and consumption of Zingiber officinale Roscoe extract on some inflammatory and anti-inflammatory factors in heart tissue of mice induced by breast cancer. J. Med. Plants. 2018; 17 (68) :32-40
URL: http://jmp.ir/article-1-1771-en.html
1- PhD Student in Sport Physiology, Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran
2- Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran , nsprofsport@gmail.com
3- Department of Physical Education and Sport Sciences, Sciences and Research Branch, Islamic Azad University, Tehran, Iran
4- Department of Exercise Physiology, Sari Branch, Islamic Azad University, Sari, Iran
Abstract:   (199 Views)
Back ground: Heart disease is one of the side effects of breast cancer. Physical activity and herbs are effective in reducing the inflammatory factors of the heart tissue.
Objective: The purpose of this study was to evaluate the effect of 6 weeks of swimming and ginger on some inflammatory factors of the heart tissue of mice induced by breast cancer.
Methods: 60 female Balb C-female (6-8 weeks old) and (150-250 g weight) after induction of breast cancer (surgical technique) and familiarity with the environment were randomly divided into 6 groups: healthy control, control Cancer, Cancer-Swim, Cancer-Supplement, Cancer-Saline-Supplement and Cancer-Saline. Swimming and swimming-Supplement groups swam for 6 weeks, five days a week and 60 minutes a day. Supplements and supplements-swimming groups were injected 6 days a day with ginger extract (20 mg / kg) and saline (sodium chloride 0.9%). After intervention, alpha-Tumor necrosis levels (TNFα) and Interleukin10 (IL10) were measured by ELISA and specialized kits. One-way analysis of variance was used to analyze the data (P <0.05).
Results: The results showed that induction of cancer was associated with an increase in TNFα and a decrease in IL10. Six weeks of swimming, supplementation and combined intervention reversed these changes. But there is no significant difference between these three independent variables.
Conclusion: Swimming, supplementation of ginger and their combination may be effective in modulating inflammatory and anti-inflammatory factors in the heart tissue of breast cancer patients.
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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2017/06/20 | Accepted: 2017/11/12 | Published: 2018/09/29

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