year 5, Issue 19 (9-2006)                   J. Med. Plants 2006, 5(19): 34-39 | Back to browse issues page

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Jamshidzadeh A, Nikmahad H. Hepatoprotective Effects of Fumaria parviflora L. on CCl4–induced hepatotoxicity. J. Med. Plants. 2006; 5 (19) :34-39
URL: http://jmp.ir/article-1-662-en.html
1- 1- Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shiraz university of Medical Sciences, Shiraz, Iran , ajamshid@sums.ac.ir
2- 1- Department of Pharmacology and Toxicology, Faculty of Pharmacy, Shiraz university of Medical Sciences, Shiraz, Iran
Abstract:   (5163 Views)
Background: Liver, the largest internal organ in the body, plays a central role in many essential physiologic processes and has numerous functions. Nevertheless, its disorders are many fold. Hepatic disease may result from a variety of therapeutic drugs or toxins that cause wide hepatic lesions. Objective: From the old times, plants have been used for the treatment of liver disorders. In this study, protective effect of hydroalcoholic extract of Fumaria parviflora L was determined. Methods: Male rats were used in this study. In the test groups, they received l00, 200 and 300mg/kg of the extract, alone or with CCl4 (3ml/kg). The liver function test and hystopathological observations were performed for all groups. Results: Carbon tetrachloride caused sever liver damage and the extract of the plant with doses higher than l00mg/kg prevented CCl4-induced liver damage Conclusion: The results of the present study support the traditional beliefs on hepatoprotective effects of Fumaria parviflora
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Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2005/02/2 | Accepted: 2006/12/20 | Published: 2006/12/21

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