year 18, Issue 72 And S12 (Supplement 12 2019)
J. Med. Plants 2019, 18(72 And S12): 133-142 |
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Mohammadifar M, Taghizadeh M, Abed A, Soltani A, Tamtaji O, Khamechian T, et al . Effect of Ziziphus jujuba Mill., Cichorium intybus L. and Silybum marianum (L.) Gaertn. Combination Extract on Non-alcoholic Fatty Liver Disease in Rats. J. Med. Plants 2019; 18 (72) :133-142
URL: http://jmp.ir/article-1-2279-en.html
URL: http://jmp.ir/article-1-2279-en.html
Mojgan Mohammadifar1 
, Mohsen Taghizadeh1 , Alireza Abed2 , Ali Soltani1 , Omidreza Tamtaji2 , Tahereh Khamechian3 , Alireza Hatami4 , Sayyed Alireza Talaei * 5
, Mohsen Taghizadeh1 , Alireza Abed2 , Ali Soltani1 , Omidreza Tamtaji2 , Tahereh Khamechian3 , Alireza Hatami4 , Sayyed Alireza Talaei * 5
1- Biochemistry and Nutrition in Metabolic Diseases Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
2- Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
3- Department of Pathology, School of Medicine, Kashan University Medical Sciences, Kashan, Iran
4- Barij Essence Medicinal Plants Research Center, Kashan, Iran
5- Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran ,talaei@kaums.ac.ir
2- Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran
3- Department of Pathology, School of Medicine, Kashan University Medical Sciences, Kashan, Iran
4- Barij Essence Medicinal Plants Research Center, Kashan, Iran
5- Physiology Research Center, Institute for Basic Sciences, Kashan University of Medical Sciences, Kashan, Iran ,
Abstract: (11766 Views)
Background: Non-alcoholic fatty liver disease (NAFLD) includes a range of liver damage from early steatosis to cirrhosis. Although NAFLD prevalence in the world is increasing, but there is no effective treatment for it.
Objective: The aim of this study was to evaluate the effect of combined extract of jujube, chicory and silymarin on NAFLD induced by high-fat diet (HFD) in rats.
Method: In this experimental study 40 male rats randomly were divided in two groups: a negative control group (n = 8) and a high-fat diet group (n = 32). After 4 months of feeding with HFD, rats were assigned into 4 groups (n = 8) including an HFD group and three groups receiving HFD and the extract at 100, 200 and 400 mg/kg for 2 months. Finally, lipid profile, liver enzymes activity and liver histology were investigated.
Results: High-fat diet increased cholesterol, triglyceride and LDL and decreased HDL levels (P<0.001). This diet also increased serum activity hepatic enzymes and lipid accumulation in liver tissue. Receiving the extract improved lipid profile and hepatic enzyme activity, dose-dependently. Histopathology of liver confirmed the change induced by HFD and protective effect of extract.
Conclusion: Treatment with combined extracts of jujube, chicory and silymarin improves high-fat diet (HFD) induced NAFLD in rats.
Objective: The aim of this study was to evaluate the effect of combined extract of jujube, chicory and silymarin on NAFLD induced by high-fat diet (HFD) in rats.
Method: In this experimental study 40 male rats randomly were divided in two groups: a negative control group (n = 8) and a high-fat diet group (n = 32). After 4 months of feeding with HFD, rats were assigned into 4 groups (n = 8) including an HFD group and three groups receiving HFD and the extract at 100, 200 and 400 mg/kg for 2 months. Finally, lipid profile, liver enzymes activity and liver histology were investigated.
Results: High-fat diet increased cholesterol, triglyceride and LDL and decreased HDL levels (P<0.001). This diet also increased serum activity hepatic enzymes and lipid accumulation in liver tissue. Receiving the extract improved lipid profile and hepatic enzyme activity, dose-dependently. Histopathology of liver confirmed the change induced by HFD and protective effect of extract.
Conclusion: Treatment with combined extracts of jujube, chicory and silymarin improves high-fat diet (HFD) induced NAFLD in rats.
Keywords: Cichorium intybus, Silybum marianum, Ziziphus jujuba, High-fat diet, Non-alcoholic fatty liver disease
Type of Study: Short Communication |
Subject:
Pharmacology & Toxicology
Received: 2018/09/20 | Accepted: 2018/12/8 | Published: 2020/03/7
Received: 2018/09/20 | Accepted: 2018/12/8 | Published: 2020/03/7
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