year 5, Issue 17 (3-2006)                   J. Med. Plants 2006, 5(17): 32-38 | Back to browse issues page

XML Persian Abstract Print


Download citation:
BibTeX | RIS | EndNote | Medlars | ProCite | Reference Manager | RefWorks
Send citation to:

Madani H, Asgary S, Naderi G, Talebolhoseini M. Hepatoprotective effect of Chichorium intybus L. on liver toxicity in rat. J. Med. Plants. 2006; 5 (17) :32-38
URL: http://jmp.ir/article-1-679-en.html
1- Department of Biology, Faculty of Sciences, Isfahan University , h.madani@sci.ui.ac.ir
2- Isfahan Cardiovascular Research Center, Isfahan University of Medical Scinnces
3- Department of Biology, Faculty of Sciences, Isfahan University
Abstract:   (5678 Views)
Background: Plant phenolic compounds such as flavonoids have important role in treatment of many diseases. Also some of them have potent hepatoprotective effects. Objective: In this study, we have investigated the protective effects of polyphenolic extracts of Silybum marianum and Chichorium intybus on thioacethamide-induced hepatotoxicity in rat. Methods: Extracts were injected to rats, at a dose of 25 mg/kg body weight together with thioacetamide at a dose of 50 mg/kg body weight. For investigation of the hepatoprotective effect of extracts against thioacetamide, activity of aminotransferases (SGOT and SGPT), alkalin phosphatase, bilyrubin, Na+ and K+ were measured. Results: significant decreases were observed in activities of aminotransferases, alkalin phosphatase and bilyrubin in groups that treated with extracts together with thioacetamide in comparation with thioacetamide treated group. Level of Na+,K+ and liver weight betwen different groups had not significant different. Conclusions: This results showed protective effect of chichorium extracts on thioacetamide-induced hepatotoxicity in rat.
Full-Text [PDF 185 kb]   (2444 Downloads)    
Type of Study: Research | Subject: Pharmacology & Toxicology
Received: 2004/05/10 | Accepted: 2004/11/23 | Published: 2006/03/20

Add your comments about this article : Your username or Email:
CAPTCHA

Send email to the article author


Rights and permissions
Creative Commons License This work is licensed under a Creative Commons Attribution-NonCommercial 4.0 International License.

© 2022 CC BY-NC 4.0 | Journal of Medicinal Plants

Designed & Developed by : Yektaweb