year 25, Issue 98 (8-2026)
J. Med. Plants 2026, 25(98): 1-16 |
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Noori T, Hosseini S Z, Korani S, Alavi S D, Heidarizade N, Mohammadi-Farani A et al . Therapeutic effect of hydroalcoholic extract of Portulaca oleracea against cuprizone-induced demyelination by targeting Nrf2/HO-1/NQO-1/NF-kB in C57BL/6 mice. J. Med. Plants 2026; 25 (98) :1-16
URL: http://jmp.ir/article-1-3809-en.html
URL: http://jmp.ir/article-1-3809-en.html
Tayebeh Noori1 
, Seyede Zahra Hosseini2 , Sina Korani2 , Seyede Darya Alavi2 , Niloofar Heidarizade2 , Ahmad Mohammadi-Farani3 , Samira Shirooie *4 
, Seyede Zahra Hosseini2 , Sina Korani2 , Seyede Darya Alavi2 , Niloofar Heidarizade2 , Ahmad Mohammadi-Farani3 , Samira Shirooie *4
1- Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran
2- Student Research Committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
3- Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran; Department of Physiology and Pharmacology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
4- Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran ,shirooie@gmail.com
2- Student Research Committee, Faculty of Pharmacy, Kermanshah University of Medical Sciences, Kermanshah, Iran
3- Medical Plants Research Center, Basic Health Sciences Institute, Shahrekord University of Medical Sciences, Shahrekord, Iran; Department of Physiology and Pharmacology, School of Medicine, Shahrekord University of Medical Sciences, Shahrekord, Iran
4- Pharmaceutical Sciences Research Center, Health Institute, Kermanshah University of Medical Sciences, Kermanshah, Iran ,
Abstract: (10 Views)
Background: Multiple sclerosis (MS) is a chronic autoimmune disorder of the central nervous system that leads to inflammatory demyelination and axonal damage. Objective: This study evaluated the therapeutic potential of Portulaca oleracea extract in a mice model of CPZ-induced multiple sclerosis. Methods: In the present experiment, CPZ was used to induce an MS-like conditions in mice. During the final two weeks of CPZ exposure, mice received P. oleracea extract at doses of 100, 200, or 300 mg/kg/day by intraperitoneal injection. After the study period, behavioral tests, histochemical examination, and immunohistochemical analysis were performed to assess HO-1, NQO-1, p-Nrf2, and NF-κB p65. Results: Compared with control group, mice fed CPZ showed significant weight loss, impaired motor function, and significant demyelination of the corpus callosum in LFB staining. Administration of P. oleracea during the last two weeks improved behavioral deficits and reduced CPZ-associated weight loss and myelin damage. In the corpus callosum, CPZ decreased the expression of HO-1, NQO-1, and
p-Nrf2 while increasing the expression of NF-κB p65. These changes were partially reversed by treatment with the extract. Conclusion: P. oleracea may be a potential candidate for further preclinical research on MS.
Type of Study: Research |
Subject:
Pharmacology & Toxicology
Received: 2024/12/30 | Accepted: 2026/06/1 | Published: 2026/08/29
Received: 2024/12/30 | Accepted: 2026/06/1 | Published: 2026/08/29
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