year 25, Issue 98 (8-2026)
J. Med. Plants 2026, 25(98): 30-39 |
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Ethics code: IR.TUMS.REC.1394.847
Clinical trials code: IRCT2015100624377N1
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Taghavi Shirazi M, Hashem-Dabaghian F, Sohrabvand F, Bioos S, Jamshidi A, Talebian A et al . Efficacy of Laboob-e Morakab Electuary, a traditional Persian formulation, in idiopathic male infertility: a quasi-experimental pilot study. J. Med. Plants 2026; 25 (98) :30-39
URL: http://jmp.ir/article-1-3763-en.html
URL: http://jmp.ir/article-1-3763-en.html
Maryam Taghavi Shirazi1 
, Fataneh Hashem-Dabaghian1 , Farnaz Sohrabvand2 , Soodabeh Bioos2 , Amirhossein Jamshidi1 , Atefe Talebian2 , Somaye Mahroozade *3
, Fataneh Hashem-Dabaghian1 , Farnaz Sohrabvand2 , Soodabeh Bioos2 , Amirhossein Jamshidi1 , Atefe Talebian2 , Somaye Mahroozade *3
1- Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran
2- Tehran University of Medical Sciences, Tehran, Iran
3- Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran ,dr.mahroozade@gmail.com
2- Tehran University of Medical Sciences, Tehran, Iran
3- Institute for Studies in Medical History, Persian and Complementary Medicine, School of Persian Medicine, Iran University of Medical Sciences, Tehran, Iran ,
Abstract: (9 Views)
Background: Male factor infertility accounts for 40-50 % of overall infertility cases. Despite medical advances, effective therapeutic options for idiopathic male infertility remain limited. Objective: This study aims to evaluate the clinical efficacy and safety of Laboob-e Morakab electuary (LME) - a traditional Persian polyherbal formulation - in improving semen parameters in men with idiopathic infertility. Methods: In a single-arm, quasi-experimental pilot study, 40 men with idiopathic male infertility received 5 g of LME orally twice daily for 3 months. Primary outcomes included sperm count, motility, morphology, and ejaculate volume, evaluated according to WHO (4th edition) guidelines at baseline and post-treatment. Statistical comparisons were performed using paired t-tests or Wilcoxon signed-rank tests. Results: Forty participants completed the 3-month intervention. LME administration significantly improved total sperm count, percentage of normal sperm morphology, and progressive motility (P < 0.001). Mean ejaculate volume increased significantly from baseline, and an improvement in libido was reported by 60 % (n = 24) of participants. No serious adverse events were observed. Conclusion: Laboob-e Morakab electuary demonstrated preliminary efficacy and safety in improving semen quality in idiopathic male infertility. Randomized, double-blind, placebo-controlled trials are warranted to confirm these findings.
Type of Study: Research |
Subject:
Medicinal Plants
Received: 2024/10/26 | Accepted: 2026/06/29 | Published: 2026/08/29
Received: 2024/10/26 | Accepted: 2026/06/29 | Published: 2026/08/29
References
1. Practice Committee of the American Society for Reproductive Medicine. Definitions of infertility and recurrent pregnancy loss: a committee opinion. Fertil Steril. 2020; 113(3): 533-535. [DOI:10.1016/j.fertnstert.2019.11.025]
2. Zhao M, Chan CPS, Cheung CWC, Alqawasmeh O, Wang RCC, Wu JCY, Lin ZX, Li TC, Chung JPW, Mak JSM, Law TSM and Chan DYL. A double-blinded, randomized placebo-controlled trial on the effect of traditional Chinese medicine formula Wuzi Yanzong pill on improving semen qualities in men with suboptimal parameters. Trials. 2019; 20(1): 540. [DOI:10.1186/s13063-019-3647-2]
3. Vander Borght M and Wyns C. Fertility and infertility: Definition and epidemiology. Clin. Biochem. 2018; 62: 2-10. [DOI:10.1016/j.clinbiochem.2018.03.012]
4. Saei Ghare Naz M, Ozgoli G and Sayehmiri K. Prevalence of infertility in Iran: A Systematic review and meta-analysis. Urol. J. 2020; 17(4): 338-345.
5. Mahroozade S and Abdolahadi A. The benefits of the diet interventions in the male idiopathic infertility based upon the Persian Medicine. Int. J. Complement. Alt. Med. 2017; 10(2): 00327. [DOI:10.15406/ijcam.2017.10.00327]
6. Esteves SC and Chan P. A systematic review of recent clinical practice guidelines and best practice statements for the evaluation of the infertile male. Int. J. Urol. Nephrol. 2015; 47(9): 1441-1456. [DOI:10.1007/s11255-015-1059-0]
7. Fainberg J and Kashanian JA. Recent advances in understanding and managing male infertility. F1000Res. 2019; 8: F1000 Faculty Rev-670. [DOI:10.12688/f1000research.17076.1]
8. Read SC, Carrier ME, Whitley R, Gold I, Tulandi T and Zelkowitz P. Complementary and alternative medicine use in infertility: cultural and religious influences in a multicultural Canadian setting. J. Altern. Complement. Med. 2014; 20(9): 686-92. [DOI:10.1089/acm.2013.0329]
9. Bioos S, Nazem E, Keshavarz M, Siahpoosh MB, Sohrabvand F, Sohanaki H and Nejatbakhsh F. A traditional Iranian medicine (Majoon-e Loboob) for idiopathic male infertility: A case series. Traditional Integrative Medicine. 2016; 1(1): 47-51.
10. Kolangi F, Shafi H, Memariani Z, Kamalinejad M, Bioos S, Jorsaraei SGA,et al. Effect of Alpinia officinarum Hance rhizome extract on spermatogram factors in men with idiopathic infertility: A prospective double‐blinded randomised clinical trial. Andrologia. 2019; 51(1): e13172. [DOI:10.1111/and.13172]
11. Miner S, Robins S, Zhu YJ, Keeren K, Gu V, Read SC and Zelkowitz P. Evidence for the use of complementary and alternative medicines during fertility treatment: A scoping review. BMC Complement. Altern. Med. 2018; 18(1): 158. [DOI:10.1186/s12906-018-2224-7]
12. Pasalar M. Persian medicine as a holistic therapeutic approach. Curr. Drug. Discov. Technol. 2021; 18(2): 159. [DOI:10.2174/157016381802210127102842]
13. Taghavi Shirazi M, Eghbalian F, Bioos S and Mahroozade S. Interdependence of skin and uterus in Persian medicine. Acta Med Hist Adriat. 2022; 20(1): 127-138. [DOI:10.31952/amha.20.1.6]
14. Mahroozade S, Sohrabvand F, Bios S, Nazem I, Nazari SM, Dabaghyan FH, Taghavi Shirazi M and Iranzad Asl M. Male infertility in Iranian traditional medicine, causes, treatment and compares it with modern medicine. IJOGI. 2016; 18(183): 1-11.
15. Kazemeini SK, Emtiazy M, Owlia F and Khani P. Causes of infertility in view of Iranian traditional medicine: A review. Int. J. Reprod. Biomed. 2017; 15(4): 187-194. [DOI:10.29252/ijrm.15.4.187]
16. Ibn Sina H. Al-Qanun Fi al-Tibb (The Canon of Medicine). 1. Beirut: Dar ehya alterase al arabi. 2005, 410-415.
17. Kermani N. Sharh al-Asbab val-Alamat. Tehran: Almaee. 2014, 439-443.
18. Khan M. Eksir-e-azam. Tafaghod R, editor. Tehran: Alma'ee. 2014, 2071-2122.
19. Aghili Khorasani M. Gharabadin Kabir. Tehran: Medical University of Tehran, Research Institute for Islamic and Complementary Medicine. 2007, 1169-1170.
20. Aghili Khorasani MH. Moalejat-e-Aghili Tehran: Iran University of Medical Sciences, Research Institute for Islamic and Complementary Medicine. 2008, 746-753.
21. Sohrabvand F, Mahroozade S, Bioos S, Nazari SM and Dabaghian FH. Improvement in sperm parameters with traditional Iranian remedy: A case report. J. Evid. Based. Complement. Altern. Med. 2017; 22(2): 223-226. [DOI:10.1177/2156587215627536]
22. Tanagho EA and McAninch JW. Male infertility. Smith's General Urology. 17 ed: McGraw-Hill Medical; 2007. p. 691.
23. Boitrelle F, Shah R, Saleh R, Henkel R, Kandil H, Chung E, Vogiatzi P, Zini A, Arafa M and Agarwal A. The sixth edition of the WHO manual for human semen analysis: a critical review and SWOT analysis. 2021; 11(12): 1368. [DOI:10.3390/life11121368]
24. Aghili Khorasani MH. Makhzan al-Advieh. Tehran: Chogan. 2017, 182, 300, 469, 590, 709, 761
25. Tonkaboni M. Tohfeh al-Momenin. 1. Tehran, Iran: Shahid Beheshti University of Medical Sciences. 2007, 154-158.
26. Nejatbakhsh F, Nazem E, Goushegir A, Isfahani MM, Nikbakht Nasrabadi A and Baygom Siahpoosh M. Recommended foods for male infertility in Iranian traditional medicine. Iran. J. Reprod. Med. 2012; 10(6): 511-6.
27. Daneshfard B, Jaladat AM. Male infertility and diet: A perspective of traditional Persian medicine. Galen Med. J. 2016; 5(2): 2016. [DOI:10.31661/gmj.v5i2.614]
28. De Luca MN, Colone M, Gambioli R, Stringaro A and Unfer V. Oxidative Stress and male fertility: role of antioxidants and inositols. Antioxidants. 2021; 10(8): 1283. [DOI:10.3390/antiox10081283]
29. Seraglio SKT, Schulz M, Gonzaga LV, Fett R and Costa ACO. Current status of the gastrointestinal digestion effects on honey: a comprehensive review. Food Chem. 2021; 357: 129807. [DOI:10.1016/j.foodchem.2021.129807]
30. Zaid SSM, Ruslee SS and Mokhtar MH. Protective roles of honey in reproductive health: a review. Molecules. 2021; 26(11): 10.3390. [DOI:10.3390/molecules26113322]
31. Mili A, Das S, Nandakumar K and Lobo R. A comprehensive review on Sesamum indicum L.: Botanical, ethnopharmacological, phytochemical, and pharmacological aspects. J Ethnopharmacol. 2021; 281: 114503. [DOI:10.1016/j.jep.2021.114503]
32. Karimi Z, Firouzi M, Dadmehr M, Javad-Mousavi SA, Bagheriani N and Sadeghpour O. Almond as a nutraceutical and therapeutic agent in Persian medicine and modern phytotherapy: a narrative review. Phytother. Res. 2021; 35(6): 2997-3012. [DOI:10.1002/ptr.7006]
33. Mohammadzadeh M, Pourentezari M, Zare-Zardini H, Nabi A, Esmailabad SG, Khodadadian A and Talebi AR. The effects of sesame oil and different doses of estradiol on testicular structure, sperm parameters, and chromatin integrity in old mice. Clin. Exp. Reprod. Med. 2021; 48(1): 34-42. [DOI:10.5653/cerm.2020.03524]
34. Khani B, Bidgoli SR, Moattar F and Hassani H. Effect of sesame on sperm quality of infertile men. J. Res. Med. Sci. 2013; 18(3): 184-7.
35. Hussein RH and Raheem SA. Effects of Almond seed oil extraction and some antioxidant agents on sperm quality in alloxan-induced diabetes mellitus rat. Int. J. Curr. Microbiol. Appl. Sci. 2015; 4(7): 93-104.
36. Sadogh A, Gorji N and Moeini R. Herbal foodstuffs in Avicenna's recommended diet to improve sperm quality and increase male fertility; An evidence-based approach. J. Complement. Integr. Med. 2021; 19(1): 47-70. [DOI:10.1515/jcim-2020-0254]
37. Aldemir M, Okulu E, Neşelioğlu S, Erel O and Kayıgil O. Pistachio diet improves erectile function parameters and serum lipid profiles in patients with erectile dysfunction. Int. J. Impot. Res. 2011; 23(1): 32-38. [DOI:10.1038/ijir.2010.33]
38. Kara H, Orem A, Yulug E, Yucesan FB, Kerimoglu G, Yaman SO, Bodur A, Turedi S and Alasalvar C.. Hazelnut consumption improves testicular antioxidant function and semen quality in young and old male rats. Food Chem. 2019; 394: 1-8. [DOI:10.1016/j.foodchem.2019.04.087]
39. Kunle-Alabi OT, Akindele OO, Oyovwi MO, Duro-Ladipo MA and Raji Y. Cocos nucifera L. water improves reproductive indices in Wistar Rats. Afr. J. Med. Health Sci. 2014; 43(4): 305-13.
40. Hosseini J, Mardi Mamaghani A, Hosseinifar H, Sadighi Gilani MA, Dadkhah F and Sepidarkish M. The influence of ginger (Zingiber officinale) on human sperm quality and DNA fragmentation: A double-blind randomized clinical trial. Int. J. Reprod Biomed. 2016; 14(8): 533-40. [DOI:10.29252/ijrm.14.8.533]
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